6PCH
| E. coli 50S ribosome bound to compound 21 | 分子名称: | (3R,4R,5E,10E,12E,14S,26aR)-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-8,9,14,15,24,25,26,26a-octahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-17 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PC7
| E. coli 50S ribosome bound to compound 46 | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-4,12-dimethyl-1,7,22-trioxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PC8
| E. coli 50S ribosome bound to compound 40q | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6WYV
| E. coli 50S ribosome bound to compounds 47 and VS1 | 分子名称: | (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2020-05-13 | 公開日 | 2020-06-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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7S1G
| wild-type Escherichia coli stalled ribosome with antibiotic linezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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7S1H
| Wild-type Escherichia coli ribosome with antibiotic linezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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7S1I
| Wild-type Escherichia coli stalled ribosome with antibiotic radezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2022-03-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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7S1J
| Wild-type Escherichia coli ribosome with antibiotic radezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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7S1K
| Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Tsai, K, Stojkovic, V, Lee, D.J, Young, I.D, Szal, T, Vazquez-Laslop, N, Mankin, A.S, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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1EVH
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6PCR
| E. coli 50S ribosome bound to compound 40o | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl (2-bromopyridin-4-yl)carbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PC5
| E. coli 50S ribosome bound to compounds 46 and VS1 | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-4,12-dimethyl-1,7,22-trioxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PCS
| E. coli 50S ribosome bound to compound 40e | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl [4-(trifluoromethyl)phenyl]carbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PCT
| E. coli 50S ribosome bound to compound 41q | 分子名称: | (2S)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PCQ
| E. coli 50S ribosome bound to VM2 | 分子名称: | (3R,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-3-(propan-2-yl)-8,9,14,15,24,25,26,26a-octahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PC6
| E. coli 50S ribosome bound to compound 47 | 分子名称: | (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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5HHD
| Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21 | 分子名称: | D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ... | 著者 | Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S. | 登録日 | 2016-01-10 | 公開日 | 2016-03-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11, 2016
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5HHC
| Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n | 分子名称: | D- Vascular endothelial growth factor-A, GLYCEROL, Vascular endothelial growth factor A | 著者 | Uppalapati, M, Lee, D.J, Mandal, K, Kent, S.B.H, Sidhu, S. | 登録日 | 2016-01-10 | 公開日 | 2016-03-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11, 2016
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5JDX
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7MFT
| Glutamate synthase, glutamate dehydrogenase counter-enzyme complex (GudB6-GltA6-GltB6) | 分子名称: | FE3-S4 CLUSTER, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Jayaraman, V, Lee, D.J, Elad, N, Fraser, J.S, Tawfik, D.S. | 登録日 | 2021-04-11 | 公開日 | 2022-01-05 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis. Nat.Chem.Biol., 18, 2022
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7MFM
| Glutamate synthase, glutamate dehydrogenase counter-enzyme complex | 分子名称: | FE3-S4 CLUSTER, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Jayaraman, V, Lee, D.J, Elad, N, Fraser, J.S, Tawfik, D.S. | 登録日 | 2021-04-10 | 公開日 | 2022-01-05 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | 主引用文献 | A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis. Nat.Chem.Biol., 18, 2022
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8E30
| E. coli 50S ribosome bound to compound streptogramin A analog 3142 | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-16 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (1.91 Å) | 主引用文献 | Potential for clicked streptogramin analogs To Be Published
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8E36
| E. coli 50S ribosome bound to compound streptogramin A analog 3146 | 分子名称: | 2-[(3R,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-1,7,22-trioxo-3-(propan-2-yl)-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-4-yl]-N-{2-[4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl]ethyl}acetamide, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-16 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | 主引用文献 | Potential for clicked streptogramin analogs To Be Published
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8E3M
| E. coli 50S ribosome bound to L-linker solithromycin conjugate | 分子名称: | 50S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-17 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.25 Å) | 主引用文献 | Solithromycin siderophore conjugates To Be Published
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8E32
| E. coli 50S ribosome bound to compound streptogramin analogs SA1 and SB1 | 分子名称: | (3R,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-yn-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-16 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | 主引用文献 | Potential for clicked streptogramin analogs To Be Published
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