6T6C
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![BU of 6t6c by Molmil](/molmil-images/mine/6t6c) | Complex with chitin oligomer of C-type lysozyme from the upper gastrointestinal tract of Opisthocomus hoatzin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Lysozyme C | Authors: | Taylor, E.J, Skjot, M, Skov, L.K, Klausen, M, De Maria, L, Gippert, G.P, Turkenburg, J.P, Davies, G.J, Wilson, K.S. | Deposit date: | 2019-10-18 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | The C-Type Lysozyme from the upper Gastrointestinal Tract of Opisthocomus hoatzin, the Stinkbird. Int J Mol Sci, 20, 2019
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2Z31
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![BU of 2z31 by Molmil](/molmil-images/mine/2z31) | Crystal structure of immune receptor complex | Descriptor: | H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain precursor, ... | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | Deposit date: | 2007-05-30 | Release date: | 2007-10-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon' Nat.Immunol., 8, 2007
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2Z35
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![BU of 2z35 by Molmil](/molmil-images/mine/2z35) | Crystal structure of immune receptor | Descriptor: | T-cell receptor alpha-chain, T-cell receptor beta-chain | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | Deposit date: | 2007-06-01 | Release date: | 2007-10-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon' Nat.Immunol., 8, 2007
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8QA4
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![BU of 8qa4 by Molmil](/molmil-images/mine/8qa4) | MTHFR + SAH symmetric dis-inhibited state | Descriptor: | Methylenetetrahydrofolate reductase (NADPH), S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Blomgren, L.K.M, Yue, W.W, Froese, D.S, McCorvie, T.J. | Deposit date: | 2023-08-22 | Release date: | 2023-11-08 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase. Nat Commun, 15, 2024
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8QA6
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![BU of 8qa6 by Molmil](/molmil-images/mine/8qa6) | MTHFR + SAM inhibited state | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase (NADPH), S-ADENOSYLMETHIONINE | Authors: | Blomgren, L.K.M, Yue, W.W, Froese, D.S, McCorvie, T.J. | Deposit date: | 2023-08-22 | Release date: | 2023-11-08 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase. Nat Commun, 15, 2024
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8QA5
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![BU of 8qa5 by Molmil](/molmil-images/mine/8qa5) | MTHFR + SAH asymmetric dis-inhibited state | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase (NADPH), S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Blomgren, L.K.M, Yue, W.W, Froese, D.S, McCorvie, T.J. | Deposit date: | 2023-08-22 | Release date: | 2023-11-08 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase. Nat Commun, 15, 2024
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1SY6
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![BU of 1sy6 by Molmil](/molmil-images/mine/1sy6) | Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment | Descriptor: | OKT3 Fab heavy chain, OKT3 Fab light chain, T-cell surface glycoprotein CD3 gamma/epsilon chain | Authors: | Kjer-Nielsen, L, Dunstone, M.A, Kostenko, L, Ely, L.K, Beddoe, T, Misfud, N.A, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J. | Deposit date: | 2004-03-31 | Release date: | 2004-05-25 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the human T cell receptor CD3(epsilon)(gamma) heterodimer complexed to the therapeutic mAb OKT3. Proc.Natl.Acad.Sci.USA, 101, 2004
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1SZR
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![BU of 1szr by Molmil](/molmil-images/mine/1szr) | A Dimer interface mutant of ornithine decarboxylase reveals structure of gem diamine intermediate | Descriptor: | N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-D-ORNITHINE, Ornithine decarboxylase, ... | Authors: | Jackson, L.K, Baldwin, J, Goldsmith, E.J, Phillips, M.A. | Deposit date: | 2004-04-06 | Release date: | 2004-10-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase Biochemistry, 43, 2004
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1SYV
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![BU of 1syv by Molmil](/molmil-images/mine/1syv) | HLA-B*4405 complexed to the dominant self ligand EEFGRAYGF | Descriptor: | Beta-2-microglobulin, MHC class I antigen, major histocompatibility complex, ... | Authors: | Zernich, D, Purcell, A.W, Macdonald, W.A, Kjer-Nielsen, L, Ely, L.K, Laham, N, Crockford, T, Mifsud, N.A, Tait, B.D, Holdsworth, R, Brooks, A.G, Bottomley, S.P, Beddoe, T, Peh, C.A, Rossjohn, J, McCluskey, J. | Deposit date: | 2004-04-02 | Release date: | 2004-10-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion J.Exp.Med., 200, 2004
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8Q3E
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![BU of 8q3e by Molmil](/molmil-images/mine/8q3e) | High Resolution Structure of Nucleosome Core with Bound Foamy Virus GAG Peptide | Descriptor: | DNA (145-MER), GLY-GLY-TYR-ASN-LEU-ARG-PRO-ARG-THR-TYR-GLN-PRO-GLN-ARG-TYR-GLY-GLY-GLY, Histone H2A type 1-B/E, ... | Authors: | De Falco, L, Batchelor, L.K, Dyson, P.J, Davey, C.A. | Deposit date: | 2023-08-04 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.174 Å) | Cite: | Viral peptide conjugates for metal-warhead delivery to chromatin. Rsc Adv, 14, 2024
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8Q3M
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![BU of 8q3m by Molmil](/molmil-images/mine/8q3m) | Structure of Nucleosome Core with a Bound Kaposi Sarcoma Associated Herpesvirus LANA Peptide Having a Methionine to Ornithine Substitution | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | Authors: | De Falco, L, Batchelor, L.K, Dyson, P.J, Davey, C.A. | Deposit date: | 2023-08-04 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Viral peptide conjugates for metal-warhead delivery to chromatin. Rsc Adv, 14, 2024
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8Q36
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![BU of 8q36 by Molmil](/molmil-images/mine/8q36) | Structure of Nucleosome Core with a Bound Metallopeptide Conjugate (Foamy Virus GAG Peptide-Au[I] Compound) | Descriptor: | DNA (145-MER), GAG structural protein, Histone H2A type 1-B/E, ... | Authors: | De Falco, L, Batchelor, L.K, Dyson, P.J, Davey, C.A. | Deposit date: | 2023-08-03 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Viral peptide conjugates for metal-warhead delivery to chromatin. Rsc Adv, 14, 2024
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8Q3X
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![BU of 8q3x by Molmil](/molmil-images/mine/8q3x) | Structure of Nucleosome Core with a Bound Metallopeptide Conjugate (Kaposi Sarcoma Associated Herpesvirus LANA Peptide-Au[I] Compound) | Descriptor: | 4-diphenylphosphanylbenzoic acid, DNA (145-MER), GOLD ION, ... | Authors: | De Falco, L, Batchelor, L.K, Dyson, P.J, Davey, C.A. | Deposit date: | 2023-08-04 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Viral peptide conjugates for metal-warhead delivery to chromatin. Rsc Adv, 14, 2024
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1SYS
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![BU of 1sys by Molmil](/molmil-images/mine/1sys) | Crystal structure of HLA, B*4403, and peptide EEPTVIKKY | Descriptor: | Beta-2-microglobulin, Sorting nexin 5, leukocyte antigen (HLA) class I molecule | Authors: | Zernich, D, Purcell, A.W, Macdonald, W.A, Kjer-Nielsen, L, Ely, L.K, Laham, N, Crockford, T, Mifsud, N.A, Tait, B.D, Holdsworth, R, Brooks, A.G, Bottomley, S.P, Beddoe, T, Peh, C.A, Rossjohn, J, McCluskey, J. | Deposit date: | 2004-04-01 | Release date: | 2004-10-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion J.Exp.Med., 200, 2004
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6DBY
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![BU of 6dby by Molmil](/molmil-images/mine/6dby) | Crystal structure of Nudix 1 from Arabidopsis thaliana | Descriptor: | MAGNESIUM ION, Nudix hydrolase 1 | Authors: | Noel, J.P, Thomas, S.T, Dudareva, N, Henry, L.K. | Deposit date: | 2018-05-03 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nat Plants, 4, 2018
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6DNZ
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![BU of 6dnz by Molmil](/molmil-images/mine/6dnz) | Trypanosoma brucei PRMT1 enzyme-prozyme heterotetrameric complex with AdoHcy | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Arginine N-methyltransferase, putative, ... | Authors: | Hashimoto, H, Kafkova, L, Jordan, K, Read, L.K, Debler, E.W. | Deposit date: | 2018-06-08 | Release date: | 2019-06-12 | Last modified: | 2020-02-12 | Method: | X-RAY DIFFRACTION (2.384 Å) | Cite: | Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme). J.Mol.Biol., 432, 2020
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6DBZ
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![BU of 6dbz by Molmil](/molmil-images/mine/6dbz) | Crystal structure of Nudix 1 from Arabidopsis thaliana complexed with isopentenyl diphosphate | Descriptor: | ISOPENTYL PYROPHOSPHATE, MAGNESIUM ION, Nudix hydrolase 1 | Authors: | Noel, J.P, Thomas, S.T, Dudareva, N, Henry, L.K. | Deposit date: | 2018-05-03 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nat Plants, 4, 2018
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7RL3
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![BU of 7rl3 by Molmil](/molmil-images/mine/7rl3) | Structure of Drosophila melanogaster Plk4 PB3 | Descriptor: | Serine/threonine-protein kinase PLK4 | Authors: | Slep, K.C, Slevin, L.K. | Deposit date: | 2021-07-23 | Release date: | 2022-08-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Polo-like kinase 4 homodimerization and condensate formation regulate its own protein levels but are not required for centriole assembly. Mol.Biol.Cell, 34, 2023
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5TJ2
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![BU of 5tj2 by Molmil](/molmil-images/mine/5tj2) | |
5FRE
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![BU of 5fre by Molmil](/molmil-images/mine/5fre) | Characterization of a novel CBM from Clostridium perfringens | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, CALCIUM ION, ... | Authors: | Ribeiro, J, Pau, W, Pifferi, C, Renaudet, O, Varrot, A, Mahal, L.K, Imberty, A. | Deposit date: | 2015-12-17 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characterization of a High-Affinity Sialic Acid-Specific Cbm40 from Clostridium Perfringens and Engineering of a Divalent Form. Biochem.J., 473, 2016
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5TJ4
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![BU of 5tj4 by Molmil](/molmil-images/mine/5tj4) | |
7RSJ
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![BU of 7rsj by Molmil](/molmil-images/mine/7rsj) | Structure of the VPS34 kinase domain with compound 14 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, N-{4-[(7R,8R)-4-oxo-7-(propan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl]pyridin-2-yl}cyclopropanecarboxamide, ... | Authors: | Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M. | Deposit date: | 2021-08-11 | Release date: | 2021-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.881 Å) | Cite: | Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J.Med.Chem., 65, 2022
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7RSP
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![BU of 7rsp by Molmil](/molmil-images/mine/7rsp) | Structure of the VPS34 kinase domain with compound 14 | Descriptor: | (7R,8R)-2-[(3R)-3-methylmorpholin-4-yl]-7-(propan-2-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3 | Authors: | Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M. | Deposit date: | 2021-08-11 | Release date: | 2021-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J.Med.Chem., 65, 2022
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7RSV
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![BU of 7rsv by Molmil](/molmil-images/mine/7rsv) | Structure of the VPS34 kinase domain with compound 5 | Descriptor: | (5aS,8aR,9S)-2-[(3R)-3-methylmorpholin-4-yl]-5,5a,6,7,8,8a-hexahydro-4H-cyclopenta[e]pyrazolo[1,5-a]pyrazin-4-one, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... | Authors: | Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M. | Deposit date: | 2021-08-11 | Release date: | 2021-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J.Med.Chem., 65, 2022
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5H0O
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![BU of 5h0o by Molmil](/molmil-images/mine/5h0o) | Crystal structure of deep-sea thermophilic bacteriophage GVE2 HNH endonuclease with manganese ion | Descriptor: | HNH endonuclease, MANGANESE (II) ION | Authors: | Zhang, L.K, Xu, D.D, Huang, Y.C, Gong, Y. | Deposit date: | 2016-10-06 | Release date: | 2017-03-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structural and functional characterization of deep-sea thermophilic bacteriophage GVE2 HNH endonuclease. Sci Rep, 7, 2017
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