1SY6

Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment

Summary for 1SY6

Entry DOI	10.2210/pdb1sy6/pdb
Descriptor	OKT3 Fab light chain, OKT3 Fab heavy chain, T-cell surface glycoprotein CD3 gamma/epsilon chain (3 entities in total)
Functional Keywords	cd3 gamma, cd3 epsilon, okt3 fab, signaling protein-antibiotic complex, signaling protein/antibiotic
Biological source	Mus musculus (house mouse) More
Cellular location	Cell membrane ; Single-pass type I membrane protein : P07766
Total number of polymer chains	3
Total formula weight	70159.85
Authors	Kjer-Nielsen, L.,Dunstone, M.A.,Kostenko, L.,Ely, L.K.,Beddoe, T.,Misfud, N.A.,Purcell, A.W.,Brooks, A.G.,McCluskey, J.,Rossjohn, J. (deposition date: 2004-03-31, release date: 2004-05-25, Last modification date: 2018-04-04)
Primary citation	Kjer-Nielsen, L.,Dunstone, M.A.,Kostenko, L.,Ely, L.K.,Beddoe, T.,Mifsud, N.A.,Purcell, A.W.,Brooks, A.G.,McCluskey, J.,Rossjohn, J. Crystal structure of the human T cell receptor CD3(epsilon)(gamma) heterodimer complexed to the therapeutic mAb OKT3. Proc.Natl.Acad.Sci.USA, 101:7675-7680, 2004 Cited by PubMed: 15136729 DOI: 10.1073/pnas.0402295101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation