8QA4

MTHFR + SAH symmetric dis-inhibited state

Summary for 8QA4

• Entry DOI: 10.2210/pdb8qa4/pdb
• EMDB information: 18298
• Descriptor: Methylenetetrahydrofolate reductase (NADPH), S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• Functional Keywords: dis-inhibited, allosteric, folate, s-adenosylhomocysteine, flavoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 151691.21

Authors

Blomgren, L.K.M.,Yue, W.W.,Froese, D.S.,McCorvie, T.J. (deposition date: 2023-08-22, release date: 2023-11-08)

• Primary citation: Blomgren, L.K.M.,Huber, M.,Mackinnon, S.R.,Burer, C.,Basle, A.,Yue, W.W.,Froese, D.S.,McCorvie, T.J.; Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.8 Å)