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PDB: 69 件

4X34
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Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2
分子名称: THR-SER-ARG-HIS-ALY-MLY-LEU-MET-PHE-LYS, Tumor suppressor p53-binding protein 1
著者Tong, Q, Kutateladze, T.G.
登録日2014-11-27
公開日2015-03-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献An Acetyl-Methyl Switch Drives a Conformational Change in p53.
Structure, 23, 2015
2PNX
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The PHD finger of ING4 in complex with an H3K4Me3 histone peptide
分子名称: H3K4Me3 peptide, Inhibitor of growth protein 4, ZINC ION
著者Champagne, K.S, Johnson, K, Kutateladze, T.G.
登録日2007-04-25
公開日2008-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation
Mol.Cell, 33, 2009
6U04
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Crystal structure of human BRPF1 PZP bound to histone H3 tail
分子名称: Histone H3.3,BRPF1, Peregrin, PRASEODYMIUM ION, ...
著者Klein, B.J, Kutateladze, T.G.
登録日2019-08-13
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.
Structure, 28, 2020
7LKY
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Crystal Structure of PHF1 Tudor domain in complex with a peptidomimetic ligand UNC6641
分子名称: DIMETHYL SULFOXIDE, Isoform 1 of PHD finger protein 1, Peptidomimetic inhibitor UNC6641, ...
著者Liu, J, Kutateladze, T.G.
登録日2021-02-03
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1).
J.Med.Chem., 64, 2021
7MJU
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Crystal structure of human AF10 PZP bound to histone H3 tail
分子名称: Histone H3.1,Protein AF-10, ZINC ION
著者Klein, B.J, Kutateladze, T.G.
登録日2021-04-20
公開日2021-08-04
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
Nat Commun, 12, 2021
8GDX
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Crystal structure of JADE1 PZP domain
分子名称: GLYCEROL, Protein Jade-1, ZINC ION
著者Klein, B.J, Liu, J, Kutateladze, T.G.
登録日2023-03-06
公開日2024-03-13
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Guiding the HBO1 complex function through the JADE subunit.
Nat.Struct.Mol.Biol., 31, 2024
8GE0
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Crystal structure of JADE1 PZP domain in complex with Histone H3
分子名称: Histone H3.1,Protein Jade-1, ZINC ION
著者Klein, B.J, Liu, J, Kutateladze, T.G.
登録日2023-03-06
公開日2024-03-13
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Guiding the HBO1 complex function through the JADE subunit.
Nat.Struct.Mol.Biol., 31, 2024
7K7T
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Crystal structure of human MORC4 ATPase-CW in complex with AMPPNP
分子名称: Isoform 3 of MORC family CW-type zinc finger protein 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Klein, B.J, Tencer, A.H, Kutateladze, T.G.
登録日2020-09-24
公開日2020-11-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Molecular mechanism of the MORC4 ATPase activation.
Nat Commun, 11, 2020
6DS6
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Crystal structure of p300 ZZ domain in complex with histone H3 peptide
分子名称: CHLORIDE ION, Histone H3 peptide-Histone acetyltransferase p300 Chimeric protein, ZINC ION
著者Zhang, Y, Kutateladze, T.G.
登録日2018-06-13
公開日2018-08-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3.
Nat. Struct. Mol. Biol., 25, 2018
8U2Y
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Solution structure of the PHD6 finger of MLL4 bound to TET3
分子名称: Histone-lysine N-methyltransferase 2D, Methylcytosine dioxygenase TET3, ZINC ION
著者Mohid, S.A, Zandian, M, Zhang, Y, Kutateladze, T.G.
登録日2023-09-06
公開日2024-06-19
実験手法SOLUTION NMR
主引用文献MLL4 binds TET3.
Structure, 32, 2024
4OUF
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Crystal Structure of CBP bromodomain
分子名称: 1,2-ETHANEDIOL, CREB-binding protein, DI(HYDROXYETHYL)ETHER
著者Roy, S, Das, C, Tyler, J.K, Kutateladze, T.G.
登録日2014-02-17
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.
Proc.Natl.Acad.Sci.USA, 111, 2014
8U77
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Crystal structure of Taf14 in complex with Yng1
分子名称: Protein YNG1, Transcription initiation factor TFIID subunit 14
著者Nguyen, M.C, Wei, P.C, Zhang, G.Y, Kutateladze, T.G.
登録日2023-09-14
公開日2024-08-21
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex.
Nat Commun, 15, 2024
3C6W
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Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptide
分子名称: H3K4me3 histone peptide, Inhibitor of growth protein 5, ZINC ION
著者Champagne, K.S, Pena, P.V, Johnson, K, Kutateladze, T.G.
登録日2008-02-05
公開日2008-06-03
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide.
Proteins, 72, 2008
1R48
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Solution structure of the C-terminal cytoplasmic domain residues 468-497 of Escherichia coli protein ProP
分子名称: Proline/betaine transporter
著者Zoetewey, D.L, Tripet, B.P, Kutateladze, T.G, Overduin, M.J, Wood, J.M, Hodges, R.S.
登録日2003-10-03
公開日2003-12-23
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution Structure of the C-terminal Antiparallel Coiled-coil Domain from Escherichia coli Osmosensor ProP.
J.Mol.Biol., 334, 2003
6WW4
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Crystal structure of HERC2 ZZ domain in complex with histone H3 tail
分子名称: GLYCEROL, Histone H3.1,E3 ubiquitin-protein ligase HERC2, ZINC ION
著者Liu, J, Vann, K.R, Kutateladze, T.G.
登録日2020-05-07
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.
Structure, 28, 2020
4HCZ
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PHF1 Tudor in complex with H3K36me3
分子名称: H3L-like histone, PHD finger protein 1
著者Musselman, C.A, Roy, S, Nunez, J, Kutateladze, T.G.
登録日2012-10-01
公開日2012-11-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.
Nat.Struct.Mol.Biol., 19, 2012
8E4V
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Solution structure of the WH domain of MORF
分子名称: Isoform 3 of Histone acetyltransferase KAT6B
著者Zhang, Y, Kutateladze, T.G.
登録日2022-08-19
公開日2023-05-10
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.
Nat Commun, 14, 2023
3RCP
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BU of 3rcp by Molmil
Crystal structure of the FAPP1 pleckstrin homology domain
分子名称: GLYCEROL, Pleckstrin homology domain-containing family A member 3
著者Roy, S, He, J, Kutateladze, T.G.
登録日2011-03-31
公開日2011-04-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain.
J.Biol.Chem., 286, 2011
6AXJ
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Crystal structure of the Yaf9 YEATS domain bound to H3K27ac
分子名称: ALY-SER-ALA-PRO-ALA, GLYCEROL, Protein AF-9 homolog, ...
著者Klein, B.J, Kutateladze, T.G.
登録日2017-09-06
公開日2017-11-22
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.379 Å)
主引用文献Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.
Nucleic Acids Res., 46, 2018
7RGW
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Crystal structure of HERC2 DOC domain
分子名称: DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase HERC2
著者Liu, J, Tencer, A.H, Kutateladze, T.G.
登録日2021-07-15
公開日2022-07-20
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献The ZZ domain of HERC2 is a receptor of arginylated substrates.
Sci Rep, 12, 2022
5ERC
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X-ray crystal structure of BRPF1 PZP domain
分子名称: CALCIUM ION, Peregrin, ZINC ION
著者Klein, B.J, Andrews, F.H, Kutateladze, T.G.
登録日2015-11-13
公開日2015-12-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.
Nucleic Acids Res., 44, 2016
5D7E
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Crystal structure of Taf14 YEATS domain in complex with H3K9ac
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, H3K9ac, ...
著者Andrews, F.H, Shanle, E.K, Strahl, B.D, Kutateladze, T.G.
登録日2015-08-13
公開日2015-09-23
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.
Genes Dev., 29, 2015
4L7X
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Crystal structure of the DIDO PHD finger in complex with H3K4me3
分子名称: Death-inducer obliterator 1, Histone H3 peptide, ZINC ION
著者Tong, Q, Gatchalian, J, Kutateladze, T.G.
登録日2013-06-14
公開日2013-07-24
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Dido3 PHD Modulates Cell Differentiation and Division.
Cell Rep, 4, 2013
4L58
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Crystal structure of the MLL5 PHD finger in complex with H3K4me3
分子名称: Histone H3 peptide, Histone-lysine N-methyltransferase MLL5, ZINC ION
著者Tong, Q, Ali, M, Kutateladze, T.G.
登録日2013-06-10
公開日2013-06-26
最終更新日2013-07-24
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Molecular basis for chromatin binding and regulation of MLL5.
Proc.Natl.Acad.Sci.USA, 110, 2013
6E86
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Solution structure of ZZZ3 ZZ domain in complex with histone H3K4ac peptide
分子名称: H3K4ac, ZINC ION, ZZ-type zinc finger-containing protein 3
著者Zhang, Y, Kutateladze, T.G.
登録日2018-07-27
公開日2018-09-19
最終更新日2024-10-16
実験手法SOLUTION NMR
主引用文献The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation.
Nat Commun, 9, 2018

 

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