7LKY

Crystal Structure of PHF1 Tudor domain in complex with a peptidomimetic ligand UNC6641

Summary for 7LKY

Entry DOI	10.2210/pdb7lky/pdb
Descriptor	Isoform 1 of PHD finger protein 1, Peptidomimetic inhibitor UNC6641, ZINC ION, ... (5 entities in total)
Functional Keywords	epigenetic reader, peptidomimetic inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	16
Total formula weight	66294.61
Authors	Liu, J.,Kutateladze, T.G. (deposition date: 2021-02-03, release date: 2021-12-15, Last modification date: 2023-10-18)
Primary citation	Engelberg, I.A.,Liu, J.,Norris-Drouin, J.L.,Cholensky, S.H.,Ottavi, S.A.,Frye, S.V.,Kutateladze, T.G.,James, L.I. Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). J.Med.Chem., 64:8510-8522, 2021 Cited by PubMed: 33999620 DOI: 10.1021/acs.jmedchem.1c00430 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation