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PDB: 75 results

7TRM
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BU of 7trm by Molmil
Crystal structure of human BIRC2 BIR3 domain in complex with inhibitor LCL-161
Descriptor: 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, LCL-161, ...
Authors:Tencer, A.H, Klein, B.J, Kutateladze, T.G.
Deposit date:2022-01-29
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.
Nat.Struct.Mol.Biol., 30, 2023
6OIE
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BU of 6oie by Molmil
The double PHD finger (DPF) of MORF in complex with histone H3K14cr
Descriptor: Histone H3.1t peptide, Histone acetyltransferase KAT6B, ZINC ION
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2019-04-09
Release date:2019-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.075 Å)
Cite:Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.
Nat Commun, 10, 2019
5D7E
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BU of 5d7e by Molmil
Crystal structure of Taf14 YEATS domain in complex with H3K9ac
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, H3K9ac, ...
Authors:Andrews, F.H, Shanle, E.K, Strahl, B.D, Kutateladze, T.G.
Deposit date:2015-08-13
Release date:2015-09-23
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.
Genes Dev., 29, 2015
6DS6
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BU of 6ds6 by Molmil
Crystal structure of p300 ZZ domain in complex with histone H3 peptide
Descriptor: CHLORIDE ION, Histone H3 peptide-Histone acetyltransferase p300 Chimeric protein, ZINC ION
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3.
Nat. Struct. Mol. Biol., 25, 2018
5ERC
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BU of 5erc by Molmil
X-ray crystal structure of BRPF1 PZP domain
Descriptor: CALCIUM ION, Peregrin, ZINC ION
Authors:Klein, B.J, Andrews, F.H, Kutateladze, T.G.
Deposit date:2015-11-13
Release date:2015-12-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.
Nucleic Acids Res., 44, 2016
4L7X
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BU of 4l7x by Molmil
Crystal structure of the DIDO PHD finger in complex with H3K4me3
Descriptor: Death-inducer obliterator 1, Histone H3 peptide, ZINC ION
Authors:Tong, Q, Gatchalian, J, Kutateladze, T.G.
Deposit date:2013-06-14
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Dido3 PHD Modulates Cell Differentiation and Division.
Cell Rep, 4, 2013
6E86
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BU of 6e86 by Molmil
Solution structure of ZZZ3 ZZ domain in complex with histone H3K4ac peptide
Descriptor: H3K4ac, ZINC ION, ZZ-type zinc finger-containing protein 3
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2018-07-27
Release date:2018-09-19
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation.
Nat Commun, 9, 2018
3RCP
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BU of 3rcp by Molmil
Crystal structure of the FAPP1 pleckstrin homology domain
Descriptor: GLYCEROL, Pleckstrin homology domain-containing family A member 3
Authors:Roy, S, He, J, Kutateladze, T.G.
Deposit date:2011-03-31
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain.
J.Biol.Chem., 286, 2011
4L58
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BU of 4l58 by Molmil
Crystal structure of the MLL5 PHD finger in complex with H3K4me3
Descriptor: Histone H3 peptide, Histone-lysine N-methyltransferase MLL5, ZINC ION
Authors:Tong, Q, Ali, M, Kutateladze, T.G.
Deposit date:2013-06-10
Release date:2013-06-26
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Molecular basis for chromatin binding and regulation of MLL5.
Proc.Natl.Acad.Sci.USA, 110, 2013
6O7G
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BU of 6o7g by Molmil
Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide
Descriptor: Histone H4, Histone-lysine N-methyltransferase 2D, ZINC ION
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2019-03-07
Release date:2019-05-22
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.
Nat Commun, 10, 2019
7TV0
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BU of 7tv0 by Molmil
Crystal structure of BRD4 bromodomain 1 in complex with dual-acetylated SARS-CoV-2 E
Descriptor: Bromodomain-containing protein 4, Envelope small membrane protein
Authors:Vann, K.R, Holt, T.A, Kutateladze, T.G.
Deposit date:2022-02-03
Release date:2022-07-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
Structure, 30, 2022
7TUQ
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BU of 7tuq by Molmil
Crystal structure of BRD4 bromodomain 1 in complex with monoacetylated SARS-CoV-2 E
Descriptor: Bromodomain-containing protein 4, Envelope small membrane protein
Authors:Vann, K.R, Kutateladze, T.G.
Deposit date:2022-02-03
Release date:2022-07-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
Structure, 30, 2022
2GP5
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BU of 2gp5 by Molmil
Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate
Descriptor: 2-OXOGLUTARIC ACID, FE (II) ION, Jumonji domain-containing protein 2A, ...
Authors:Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G.
Deposit date:2006-04-16
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural insights into histone demethylation by JMJD2 family members
Cell(Cambridge,Mass.), 125, 2006
2GP3
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BU of 2gp3 by Molmil
Crystal structure of the catalytic core domain of jmjd2a
Descriptor: FE (II) ION, Jumonji domain-containing protein 2A, ZINC ION
Authors:Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G.
Deposit date:2006-04-16
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insights into histone demethylation by JMJD2 family members
Cell(Cambridge,Mass.), 125, 2006
2G6Q
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BU of 2g6q by Molmil
Crystal structure of ING2 PHD finger in complex with H3K4Me3 peptide
Descriptor: H3K4Me3 peptide, Inhibitor of growth protein 2, ZINC ION
Authors:Pena, P.V, Zhao, R, Kutateladze, T.G.
Deposit date:2006-02-24
Release date:2006-07-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.
Nature, 442, 2006
6MIM
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BU of 6mim by Molmil
Crystal structure of AF9 YEATS domain Y78W mutant in complex with histone H3K9cr
Descriptor: Histone H3K9cr, Protein AF-9
Authors:Vann, K.R, Klein, B.J, Kutateladze, T.G.
Deposit date:2018-09-19
Release date:2018-11-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.525 Å)
Cite:Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
6MIN
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BU of 6min by Molmil
Crystal structure of Taf14 YEATS domain G82A mutant in complex with histone H3K9cr
Descriptor: Histone H3K9cr, Transcription initiation factor TFIID subunit 14
Authors:Klein, B.J, Andrews, F.H, Kutateladze, T.G.
Deposit date:2018-09-19
Release date:2018-11-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
6MIQ
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BU of 6miq by Molmil
Crystal structure of Taf14 YEATS domain in complex with histone H3K9bu
Descriptor: Histone H3K9bu, Transcription initiation factor TFIID subunit 14
Authors:Klein, B.J, Andrews, F.H, Vann, K.R, Kutateladze, T.G.
Deposit date:2018-09-19
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
6MIO
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BU of 6mio by Molmil
Crystal structure of Taf14 YEATS domain in complex with histone H3K9pr
Descriptor: Histone H3K9pr, Transcription initiation factor TFIID subunit 14
Authors:Klein, B.J, Andrews, F.H, Vann, K.R, Kutateladze, T.G.
Deposit date:2018-09-19
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
6MIP
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BU of 6mip by Molmil
Crystal structure of Taf14 YEATS domain G82A mutant
Descriptor: DI(HYDROXYETHYL)ETHER, Transcription initiation factor TFIID subunit 14
Authors:Klein, B.J, Andrews, F.H, Kutateladze, T.G.
Deposit date:2018-09-19
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
6MIL
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BU of 6mil by Molmil
Crystal structure of AF9 YEATS domain in complex with histone H3K9bu
Descriptor: DI(HYDROXYETHYL)ETHER, Histone H3K9bu, MALONATE ION, ...
Authors:Vann, K.R, Klein, B.J, Kutateladze, T.G.
Deposit date:2018-09-19
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
3LH0
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BU of 3lh0 by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K372me2
Descriptor: DIMETHYLATED p53 LYSINE 372 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Roy, S, Kutateladze, T.G.
Deposit date:2010-01-21
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
3LGF
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BU of 3lgf by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2
Descriptor: DIMETHYLATED p53 Lysine 370 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Roy, S, Kutateladze, T.G.
Deposit date:2010-01-20
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
3LGL
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BU of 3lgl by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K382me2
Descriptor: DIMETHYLATED p53 LYSINE 382 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Roy, S, Kutateladze, T.G.
Deposit date:2010-01-20
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
6WXK
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BU of 6wxk by Molmil
PHF23 PHD Domain Apo
Descriptor: PHD finger protein 23, ZINC ION
Authors:Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T.
Deposit date:2020-05-11
Release date:2020-07-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nat Commun, 11, 2020

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