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PDB: 98 件
3EJT
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BU of 3ejt by Molmil
Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog:(5R)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine
分子名称: (1S,2R,5R,8R,8aR)-5-[2-(4-tert-butylphenyl)ethyl]octahydroindolizine-1,2,8-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Shea, K, Rose, D.R.
登録日2008-09-18
公開日2009-10-13
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II.
Chembiochem, 11, 2010
3EJR
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BU of 3ejr by Molmil
Golgi alpha-Mannosidase II in complex with 5-substitued swainsonine analog: (5R)-5-[2'-oxo-2'-(4-tert-butylphenyl)ethyl]-swainsonine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-(4-tert-butylphenyl)-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Shea, K, Rose, D.R.
登録日2008-09-18
公開日2009-10-13
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II.
Chembiochem, 11, 2010
3EJU
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BU of 3eju by Molmil
Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog:(5S)-5-[2'-oxo-2'-(4-tert-butylphenyl)ethyl]-swainsonine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-(4-tert-butylphenyl)-2-[(1S,2R,5S,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Shea, K, Rose, D.R.
登録日2008-09-18
公開日2009-10-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II.
Chembiochem, 11, 2010
3BUI
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BU of 3bui by Molmil
Golgi mannosidase II D204A catalytic nucleophile mutant complex with Tris
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-mannosidase 2, ...
著者Kuntz, D.A, Rose, D.R.
登録日2008-01-02
公開日2008-07-01
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant.
J.Am.Chem.Soc., 130, 2008
3BVT
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BU of 3bvt by Molmil
GOLGI MANNOSIDASE II D204A catalytic nucleophile mutant complex with Methyl (alpha-D-mannopyranosyl)-(1->3)-S-alpha-D-mannopyranoside
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Rose, D.R.
登録日2008-01-07
公開日2008-07-01
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant.
J.Am.Chem.Soc., 130, 2008
3BLB
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BU of 3blb by Molmil
Crystal structure of Golgi Mannosidase II in complex with swainsonine at 1.3 Angstrom resolution
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Rose, D.R.
登録日2007-12-10
公開日2008-01-08
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Golgi Mannosidase II in complex with swainsonine at 1.3 Angstrom.
To Be Published
3EJQ
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BU of 3ejq by Molmil
Golgi alpha-Mannosidase II in complex with 5-substitued swainsonine analog: (5R)-5-[2'-oxo-2'-(4-methylphenyl)ethyl]-swainsonine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-(4-methylphenyl)-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Rose, D.R.
登録日2008-09-18
公開日2009-10-13
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II.
Chembiochem, 11, 2010
3CUH
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BU of 3cuh by Molmil
Cellulomonas fimi Xylanase/Cellulase Cex (Cf Xyn10A) in complex with cellotriose-like isofagomine
分子名称: (3R,4R,5R)-3-hydroxy-5-(hydroxymethyl)piperidin-4-yl 4-O-beta-D-glucopyranosyl-beta-D-glucopyranoside, Exo-beta-1,4-glucanase
著者Kuntz, D.A, Saul, M, Rose, D.R.
登録日2008-04-16
公開日2009-04-21
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Probing the binding sites of Family 10 and 11 Xylanases with extended Oligosaccharides
to be published
3D50
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BU of 3d50 by Molmil
GOLGI MANNOSIDASE II complex with N-octyl-6-epi-valienamine
分子名称: (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Tarling, C.A, Withers, S.G, Rose, D.R.
登録日2008-05-15
公開日2008-08-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen.
Biochemistry, 47, 2008
3D52
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BU of 3d52 by Molmil
GOLGI MANNOSIDASE II complex with an N-aryl carbamate derivative of gluco-hydroxyiminolactam
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Alpha-mannosidase 2, ZINC ION, ...
著者Kuntz, D.A, Tarling, C.A, Withers, S.G, Rose, D.R.
登録日2008-05-15
公開日2008-08-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen.
Biochemistry, 47, 2008
3EJP
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BU of 3ejp by Molmil
Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5R)-5-[2'-oxo-2'-(phenyl)ethyl]-swainsonine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-phenyl-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kuntz, D.A, Rose, D.R.
登録日2008-09-18
公開日2009-10-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II.
Chembiochem, 11, 2010
8VM2
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BU of 8vm2 by Molmil
Crystal Structure of NRAS Q61K bound to GTP
分子名称: GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Gebregiworgis, T, Chan, J.Y.L, Kuntz, D.A, Prive, G.G, Marshall, C.B, Ikura, M.
登録日2024-01-12
公開日2024-05-01
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
Eur J Cell Biol, 103, 2024
1MVU
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BU of 1mvu by Molmil
SINGLE CHAIN FV OF C219 HEAVY CHAIN V101L MUTANT IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE
分子名称: Ig VDJ-region (HEAVY CHAIN), Ig kappa-chain VJ-region (Light chain), P-GLYCOPROTEIN, ...
著者Chan, D.C.M, Kuntz, D.A, Rose, D.R.
登録日2002-09-26
公開日2003-10-07
最終更新日2013-09-18
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Single Chain C219 V(101H)L Mutant Antibody Complexed with a Helical Peptide
To be Published
7SCW
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BU of 7scw by Molmil
KRAS full length wild-type in complex with RGL1 Ras association domain
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ...
著者Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B.
登録日2021-09-29
公開日2022-05-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.
J.Mol.Biol., 434, 2022
7SCX
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BU of 7scx by Molmil
KRAS full-length G12V in complex with RGL1 Ras association domain
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ...
著者Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B.
登録日2021-09-29
公開日2022-05-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.
J.Mol.Biol., 434, 2022
1HWW
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BU of 1hww by Molmil
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R.
登録日2001-01-10
公開日2002-01-10
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HTY
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BU of 1hty by Molmil
GOLGI ALPHA-MANNOSIDASE II
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R.
登録日2001-01-02
公開日2002-01-02
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HXK
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BU of 1hxk by Molmil
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-DEOXYMANNOJIRIMYCIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R.
登録日2001-01-16
公開日2002-01-16
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1QWN
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GOLGI ALPHA-MANNOSIDASE II Covalent Intermediate Complex with 5-fluoro-gulosyl-fluoride
分子名称: (2R,3S,4R,5S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R.
登録日2003-09-02
公開日2003-10-07
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1QWU
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Golgi alpha-mannosidase II D341N mutant complex with 5-F-guloside
分子名称: (2R,3S,4R,5S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R.
登録日2003-09-03
公開日2003-10-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1PS3
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BU of 1ps3 by Molmil
Golgi alpha-mannosidase II in complex with kifunensine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase II, ...
著者Shah, N, Kuntz, D.A, Rose, D.R.
登録日2003-06-20
公開日2003-12-16
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms
Biochemistry, 42, 2003
1QX1
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BU of 1qx1 by Molmil
Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-2-fluoro-beta-D-mannopyranosyl fluoride, ...
著者Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R.
登録日2003-09-04
公開日2003-10-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
3CV5
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BU of 3cv5 by Molmil
GOLGI MANNOSIDASE II D204A catalytic nucleophile mutant complex with 3alpha,6alpha-mannopentaose
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase 2, ...
著者Shah, N, Kuntz, D.A, Rose, D.R.
登録日2008-04-17
公開日2008-06-24
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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