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PDB: 71 件

3JSQ
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Crystal structure of adipocyte fatty acid binding protein non-covalently modified with 4-hydroxy-2-nonenal
分子名称: (2E,4R)-4-HYDROXYNON-2-ENAL, Adipocyte fatty acid-binding protein, CHLORIDE ION, ...
著者Hellberg, K, Grimsrud, P.A, Kruse, A.C, Banaszak, L.J, Ohlendorf, D.H, Bernlohr, D.A.
登録日2009-09-10
公開日2010-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal.
Protein Sci., 19, 2010
8UFG
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Acinetobacter baylyi LptB2FG bound to Acinetobacter baylyi lipopolysaccharide
分子名称: (2~{R},4~{R},5~{R},6~{R})-2-[(2~{R},4~{R},5~{R},6~{R})-5-[(2~{S},4~{R},5~{R},6~{R})-4-[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-acetamido-6-carboxy-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-5-oxidanyl-oxan-2-yl]oxy-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-4-[(3~{S})-3-dodecanoyloxydodecanoyl]oxy-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-heptanoyloxyundecanoyl]amino]-3-oxidanyl-4-[(3~{R})-3-oxidanyloctanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-5-[[(3~{S})-3-[(3~{R})-3-oxidanyldecanoyl]oxydecanoyl]amino]-3-phosphonooxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, DODECYL-BETA-D-MALTOSIDE, LPS export ABC transporter permease LptG, ...
著者Pahil, K.S, Gilman, M.S.A, Baidin, V, Kruse, A.C, Kahne, D.
登録日2023-10-04
公開日2024-01-03
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
Nature, 625, 2024
8TH4
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Structure of AT118-L Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor and Losartan
分子名称: AT118-L Nanobody, BAG2 Anti-BRIL Fab Heavy Chain, BAG2 Anti-BRIL Fab Light Chain, ...
著者Skiba, M.A, Kruse, A.C.
登録日2023-07-13
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Antibodies expand the scope of angiotensin receptor pharmacology.
Nat.Chem.Biol., 2024
8TH3
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Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
分子名称: AT118-H nanobody, Type-1 angiotensin II receptor, Soluble cytochrome b562 complex, ...
著者Skiba, M.A, Kruse, A.C.
登録日2023-07-13
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Antibodies expand the scope of angiotensin receptor pharmacology.
Nat.Chem.Biol., 2024
6U6N
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Structure of the trimeric globular domain of Adiponectin mutant - D187A Q188A
分子名称: Adiponectin, CHLORIDE ION
著者Pascolutti, R, Kruse, A.C, Erlandson, S.C, Burri, D.J, Zheng, S.
登録日2019-08-30
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Mapping and engineering the interaction between adiponectin and T-cadherin.
J.Biol.Chem., 295, 2020
6BAR
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Crystal structure of Thermus thermophilus Rod shape determining protein RodA (Q5SIX3_THET8)
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Rod shape determining protein RodA
著者Sjodt, M, Brock, K, Dobihal, G, Rohs, P.D.A, Green, A.G, Hopf, T.A, Meeske, A.J, Marks, D.S, Bernhardt, T.G, Rudner, D.Z, Kruse, A.C.
登録日2017-10-15
公開日2018-03-28
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.908 Å)
主引用文献Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis.
Nature, 556, 2018
6BAS
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Crystal structure of Thermus thermophilus Rod shape determining protein RodA D255A mutant (Q5SIX3_THET8)
分子名称: CHLORIDE ION, Peptidoglycan glycosyltransferase RodA
著者Sjodt, M, Brock, K, Dobihal, G, Rohs, P.D.A, Green, A.G, Hopf, T.A, Meeske, A.J, Marks, D.S, Bernhardt, T.G, Rudner, D.Z, Kruse, A.C.
登録日2017-10-15
公開日2018-03-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.194 Å)
主引用文献Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis.
Nature, 556, 2018
8FRP
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Acinetobacter baylyi LptB2FGC
分子名称: LPS export ABC transporter permease LptG, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ...
著者Pahil, K.S, Gilman, M.S.A, Kruse, A.C, Kahne, D.
登録日2023-01-07
公開日2024-01-03
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
Nature, 625, 2024
8FRM
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Acinetobacter baylyi LptB2FG bound to lipopolysaccharide.
分子名称: (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, LPS export ABC transporter permease LptG, Lipopolysaccharide export system ATP-binding protein LptB, ...
著者Pahil, K.S, Gilman, M.S.A, Kruse, A.C, Kahne, D.
登録日2023-01-07
公開日2024-01-03
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.14 Å)
主引用文献A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
Nature, 625, 2024
8FRL
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Acinetobacter baylyi LptB2FG bound to lipopolysaccharide and a macrocyclic peptide
分子名称: (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, (7S,10S,13S,17P)-10-(4-aminobutyl)-7-(3-aminopropyl)-17-(6-aminopyridin-3-yl)-20-chloro-13-[(1H-indol-3-yl)methyl]-12-methyl-6,7,9,10,12,13,15,16-octahydropyrido[2,3-b][1,5,8,11,14]benzothiatetraazacycloheptadecine-8,11,14(5H)-trione, DODECYL-BETA-D-MALTOSIDE, ...
著者Pahil, K.S, Gilman, M.S.A, Kruse, A.C, Kahne, D.
登録日2023-01-07
公開日2024-01-03
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
Nature, 625, 2024
8FRN
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Acinetobacter baylyi LptB2FG bound to lipopolysaccharide and Zosurabalpin
分子名称: (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, DODECYL-BETA-D-MALTOSIDE, LPS export ABC transporter permease LptG, ...
著者Pahil, K.S, Gilman, M.S.A, Kruse, A.C, Kahne, D.
登録日2023-01-07
公開日2024-01-03
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
Nature, 625, 2024
8FRO
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Acinetobacter baylyi LptB2FG bound to lipopolysaccharide and a macrocyclic peptide
分子名称: (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, (7S,10S,13S)-10-(4-aminobutyl)-7-(3-aminopropyl)-17,20-dichloro-13-[(1H-indol-3-yl)methyl]-12-methyl-6,7,9,10,12,13,15,16-octahydropyrido[2,3-b][1,5,8,11,14]benzothiatetraazacycloheptadecine-8,11,14(5H)-trione, LPS export ABC transporter permease LptG, ...
著者Pahil, K.S, Gilman, M.S.A, Kruse, A.C, Kahne, D.
登録日2023-01-07
公開日2024-01-03
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
Nature, 625, 2024
4EJ4
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Structure of the delta opioid receptor bound to naltrindole
分子名称: (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol, Delta-type opioid receptor, Lysozyme chimera
著者Granier, S, Manglik, A, Kruse, A.C, Kobilka, T.S, Thian, F.S, Weis, W.I, Kobilka, B.K.
登録日2012-04-06
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of the delta opioid receptor bound to naltrindole
Nature, 485, 2012
4JQI
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Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide
分子名称: 1,2-ETHANEDIOL, Beta-arrestin-1, CHLORIDE ION, ...
著者Shukla, A.K, Manglik, A, Kruse, A.C, Xiao, K, Reis, R.I, Tseng, W.C, Staus, D.P, Hilger, D, Uysal, S, Huang, L.H, Paduch, M, Shukla, P.T, Koide, A, Koide, S, Weis, W.I, Kossiakoff, A.A, Kobilka, B.K, Lefkowitz, R.J.
登録日2013-03-20
公開日2013-04-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Nature, 497, 2013
7M93
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Bovine sigma-2 receptor bound to PB28
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, PB28, Sigma intracellular receptor 2
著者Alon, A, Kruse, A.C.
登録日2021-03-30
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
Nature, 600, 2021
7TJ4
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Structure of the S. aureus amidase LytH and activator ActH extracellular domains
分子名称: ActH, LytH, ZINC ION
著者Page, J.E, Skiba, M.A, Kruse, A.C, Walker, S.
登録日2022-01-14
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
5HK2
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Human sigma-1 receptor bound to 4-IBP
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, N-(1-benzylpiperidin-4-yl)-4-iodobenzamide, SULFATE ION, ...
著者Schmidt, H.R, Zheng, S, Gurpinar, E.G, Koehl, A, Manglik, A, Kruse, A.C.
登録日2016-01-13
公開日2016-04-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the human sigma 1 receptor.
Nature, 532, 2016
7M95
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Bovine sigma-2 receptor bound to Z1241145220
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[1-(3-phenylpropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine, CHOLESTEROL, ...
著者Alon, A, Kruse, A.C.
登録日2021-03-30
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
Nature, 600, 2021
7MFI
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Bovine sigma-2 receptor bound to cholesterol
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ...
著者Alon, A, Kruse, A.C.
登録日2021-04-09
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
Nature, 600, 2021
7M94
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Bovine sigma-2 receptor bound to Roluperidone
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Roluperidone, Sigma intracellular receptor 2
著者Alon, A, Kruse, A.C.
登録日2021-03-30
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
Nature, 600, 2021
7M96
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Bovine sigma-2 receptor bound to Z4857158944
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-({[(1S)-1-hydroxy-2-methyl-1-phenylpropan-2-yl]amino}methyl)-1-methyl-3,4-dihydroquinolin-2(1H)-one, ...
著者Alon, A, Kruse, A.C.
登録日2021-03-30
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
Nature, 600, 2021
4LDO
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Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, Camelid Antibody Fragment, L-EPINEPHRINE, ...
著者Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
登録日2013-06-24
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
5HK1
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Human sigma-1 receptor bound to PD144418
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-(4-methylphenyl)-5-(1-propyl-3,6-dihydro-2H-pyridin-5-yl)-1,2-oxazole, SULFATE ION, ...
著者Schmidt, H.R, Zheng, S, Gurpinar, E, Koehl, A, Manglik, A, Kruse, A.C.
登録日2016-01-13
公開日2016-04-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.5051 Å)
主引用文献Crystal structure of the human sigma 1 receptor.
Nature, 532, 2016
4LDE
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Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ...
著者Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
登録日2013-06-24
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
4LDL
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BU of 4ldl by Molmil
Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol, Camelid Antibody Fragment, ...
著者Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
登録日2013-06-24
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013

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件を2024-07-24に公開中

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