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PDB: 165 件
4PWH
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Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester
分子名称: 3-methylbut-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, CALCIUM ION, Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2014-03-20
公開日2014-11-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.798 Å)
主引用文献Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWI
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Crystal structure of V30M mutant human transthyretin complexed with rosmarinic acid
分子名称: (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2014-03-20
公開日2014-11-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.494 Å)
主引用文献Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWE
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Crystal structure of V30M mutant human transthyretin
分子名称: Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2014-03-20
公開日2014-11-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWJ
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Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid
分子名称: 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2014-03-20
公開日2014-11-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWG
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Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester
分子名称: CALCIUM ION, Transthyretin, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2014-03-20
公開日2014-11-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.798 Å)
主引用文献Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWK
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BU of 4pwk by Molmil
Crystal structure of V30M mutant human transthyretin complexed with dihydroguaiaretic acid
分子名称: 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol), Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2014-03-20
公開日2014-11-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4QRF
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BU of 4qrf by Molmil
Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester
分子名称: 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2014-06-30
公開日2014-11-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
8II3
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Crystal structure of V30M-TTR in complex with 6-hydroxy BID
分子名称: Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone
著者Yokoyama, T.
登録日2023-02-24
公開日2023-06-28
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.399 Å)
主引用文献Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
8II1
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Crystal structure of V30M-TTR in complex with BID
分子名称: Benziodarone, Transthyretin
著者Yokoyama, T.
登録日2023-02-24
公開日2023-06-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.907 Å)
主引用文献Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
8II4
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Crystal structure of V30M-TTR in complex with 6-hydroxy BBM
分子名称: Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone
著者Yokoyama, T.
登録日2023-02-24
公開日2023-06-28
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.499 Å)
主引用文献Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
8II2
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Crystal structure of V30M-TTR in complex with BBM
分子名称: CALCIUM ION, Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone
著者Yokoyama, T.
登録日2023-02-24
公開日2023-06-28
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.798 Å)
主引用文献Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
8W42
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X-ray crystal structure of V30M-TTR in complex with resveratrol
分子名称: RESVERATROL, SODIUM ION, Transthyretin
著者Yokoyama, T.
登録日2023-08-23
公開日2023-11-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W44
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X-ray crystal structure of V30M-TTR in complex with oxyresveratrol
分子名称: SODIUM ION, Transthyretin, trans-oxyresveratrol
著者Yokoyama, T.
登録日2023-08-23
公開日2023-11-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.399 Å)
主引用文献Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W46
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X-ray crystal structure of V30M-TTR in complex with pterostilbene
分子名称: Pterostilbene, SODIUM ION, Transthyretin
著者Yokoyama, T.
登録日2023-08-23
公開日2023-11-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W48
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BU of 8w48 by Molmil
Neutron and X-ray joint structure of WT-TTR in complex with piceatannol
分子名称: PICEATANNOL, Transthyretin
著者Yokoyama, T, Kusaka, K, Fujiwara, S.
登録日2023-08-23
公開日2023-11-22
最終更新日2023-12-06
実験手法NEUTRON DIFFRACTION (1.19 Å), X-RAY DIFFRACTION
主引用文献Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8IG1
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BU of 8ig1 by Molmil
Crystal structure of wild-type transthyretin in complex with rafoxanide
分子名称: SODIUM ION, Transthyretin, ~{N}-[3-chloranyl-4-(4-chloranylphenoxy)phenyl]-3,5-bis(iodanyl)-2-oxidanyl-benzamide
著者Yokoyama, T.
登録日2023-02-20
公開日2023-08-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.451 Å)
主引用文献Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin.
Febs J., 290, 2023
8W43
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BU of 8w43 by Molmil
X-ray crystal structure of V30M-TTR in complex with piceatannol
分子名称: PICEATANNOL, SODIUM ION, Transthyretin
著者Yokoyama, T.
登録日2023-08-23
公開日2023-11-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.302 Å)
主引用文献Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W45
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X-ray crystal structure of V30M-TTR in complex with pinostilbene
分子名称: 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin
著者Yokoyama, T.
登録日2023-08-23
公開日2023-11-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8W47
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X-ray crystal structure of V30M-TTR in complex with isorhapontigenin
分子名称: 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, SODIUM ION, Transthyretin
著者Yokoyama, T.
登録日2023-08-23
公開日2023-11-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
4N85
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Crystal structure of human transthyretin
分子名称: CALCIUM ION, Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2013-10-17
公開日2014-02-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of human transthyretin complexed with glabridin
J.Med.Chem., 57, 2014
4N86
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Crystal structure of human transthyretin complexed with glabridin
分子名称: 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, CALCIUM ION, Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2013-10-17
公開日2014-02-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Crystal structures of human transthyretin complexed with glabridin
J.Med.Chem., 57, 2014
4N87
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Crystal structure of V30M mutant human transthyretin complexed with glabridin
分子名称: 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, Transthyretin
著者Yokoyama, T, Kosaka, Y, Mizuguchi, M.
登録日2013-10-17
公開日2014-02-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.794 Å)
主引用文献Crystal structures of human transthyretin complexed with glabridin
J.Med.Chem., 57, 2014
7CPJ
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ycbZ-stalled 70S ribosome
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Yokoyama, T, Shirouzu, M, Ito, T.
登録日2020-08-07
公開日2021-12-08
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The landscape of translational stall sites in bacteria revealed by monosome and disome profiling.
Rna, 28, 2022
4Y9B
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Crystal structure of V30M mutated transthyretin in complex with alpha-mangostin
分子名称: 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, CALCIUM ION, CHLORIDE ION, ...
著者Yokoyama, T, Mizuguchi, M.
登録日2015-02-17
公開日2015-09-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor
Sci Rep, 5, 2015
4Y9F
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Crystal structure of V30M mutated transthyretin with bromide in complex with gamma-mangostin
分子名称: 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, BROMIDE ION, Transthyretin
著者Yokoyama, T, Mizuguchi, M.
登録日2015-02-17
公開日2015-09-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor
Sci Rep, 5, 2015

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件を2024-07-10に公開中

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