4FI3
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![BU of 4fi3 by Molmil](/molmil-images/mine/4fi3) | Structure of vitamin B12 transporter BtuCD-F in a nucleotide-bound state | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Vitamin B12 import ATP-binding protein BtuD, ... | Authors: | Korkhov, V.M, Mireku, S.A, Locher, K.P. | Deposit date: | 2012-06-07 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.466 Å) | Cite: | Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F. Nature, 490, 2012
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7NUR
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4DBL
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![BU of 4dbl by Molmil](/molmil-images/mine/4dbl) | Crystal structure of E159Q mutant of BtuCDF | Descriptor: | PHOSPHATE ION, SULFATE ION, Vitamin B12 import ATP-binding protein BtuD, ... | Authors: | Korkhov, V.M, Mireku, S.M, Hvorup, R.N, Locher, K.P. | Deposit date: | 2012-01-16 | Release date: | 2012-03-07 | Last modified: | 2012-05-23 | Method: | X-RAY DIFFRACTION (3.493 Å) | Cite: | Asymmetric states of vitamin B12 transporter BtuCD are not discriminated by its cognate substrate binding protein BtuF. Febs Lett., 586, 2012
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4R9U
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![BU of 4r9u by Molmil](/molmil-images/mine/4r9u) | Structure of vitamin B12 transporter BtuCD in a nucleotide-bound outward facing state | Descriptor: | LAURYL DIMETHYLAMINE-N-OXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Korkhov, V.M, Mireku, S.A, Veprintsev, D.B, Locher, K.P. | Deposit date: | 2014-09-08 | Release date: | 2014-11-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.785 Å) | Cite: | Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F. Nat.Struct.Mol.Biol., 21, 2014
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6R4P
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6R3Q
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6TBU
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![BU of 6tbu by Molmil](/molmil-images/mine/6tbu) | Structure of Drosophila melanogaster Dispatched | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Korkhov, V.M, Cannac, F. | Deposit date: | 2019-11-04 | Release date: | 2020-06-03 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Cryo-EM structure of the Hedgehog release protein Dispatched. Sci Adv, 6, 2020
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6TD6
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6RMG
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![BU of 6rmg by Molmil](/molmil-images/mine/6rmg) | Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Korkhov, V.M, Qi, C. | Deposit date: | 2019-05-06 | Release date: | 2019-10-09 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of sterol recognition by human hedgehog receptor PTCH1. Sci Adv, 5, 2019
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8JPS
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![BU of 8jps by Molmil](/molmil-images/mine/8jps) | Structure of Duffy Antigen Receptor for Chemokines (DARC)/ACKR1 in complex with the chemokine, CCL7 (Composite map) | Descriptor: | Atypical chemokine receptor 1, C-C motif chemokine 7 | Authors: | Banerjee, R, Khanppnavar, B, Maharana, J, Saha, S, Korkhov, V.M, Shukla, A.K. | Deposit date: | 2023-06-12 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor. Cell, 187, 2024
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8BUZ
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![BU of 8buz by Molmil](/molmil-images/mine/8buz) | Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... | Authors: | Khanppnavar, B, Korkhov, V.M, Mehta, V. | Deposit date: | 2022-12-01 | Release date: | 2023-12-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
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8BV5
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![BU of 8bv5 by Molmil](/molmil-images/mine/8bv5) | Focus refinement of soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc conditions | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... | Authors: | Khanppnavar, B, Korkhov, V.M. | Deposit date: | 2023-01-04 | Release date: | 2024-01-17 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
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6R4O
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![BU of 6r4o by Molmil](/molmil-images/mine/6r4o) | Structure of a truncated adenylyl cyclase bound to MANT-GTP, forskolin and an activated stimulatory Galphas protein | Descriptor: | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, ... | Authors: | Qi, C, Sorrentino, S, Medalia, O, Korkhov, V.M. | Deposit date: | 2019-03-22 | Release date: | 2019-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science, 364, 2019
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5O5L
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8R7Q
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![BU of 8r7q by Molmil](/molmil-images/mine/8r7q) | |
8R7P
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8QOJ
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5O5K
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![BU of 5o5k by Molmil](/molmil-images/mine/5o5k) | X-ray structure of a bacterial adenylyl cyclase soluble domain | Descriptor: | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... | Authors: | Vercellino, I, Korkhov, V.M. | Deposit date: | 2017-06-02 | Release date: | 2017-11-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5M34
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![BU of 5m34 by Molmil](/molmil-images/mine/5m34) | Structure of cobinamide-bound BtuF mutant W66Y, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-14 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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5M2Q
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![BU of 5m2q by Molmil](/molmil-images/mine/5m2q) | Structure of cobinamide-bound BtuF mutant W66F, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-13 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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5M29
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![BU of 5m29 by Molmil](/molmil-images/mine/5m29) | Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-12 | Release date: | 2017-02-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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5M3B
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![BU of 5m3b by Molmil](/molmil-images/mine/5m3b) | Structure of cobinamide-bound BtuF mutant W66L, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-14 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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7PD4
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7PD8
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7PDH
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