6RMG

Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II

Summary for 6RMG

• Entry DOI: 10.2210/pdb6rmg/pdb
• EMDB information: 4936
• Descriptor: Protein patched homolog 1,GFP-like fluorescent chromoprotein FP506, related, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: patched, ptch1, hedgehog, shhn, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 203194.08

Authors

Korkhov, V.M.,Qi, C. (deposition date: 2019-05-06, release date: 2019-10-09, Last modification date: 2020-07-29)

• Primary citation: Qi, C.,Di Minin, G.,Vercellino, I.,Wutz, A.,Korkhov, V.M.; Structural basis of sterol recognition by human hedgehog receptor PTCH1.; Sci Adv, 5:eaaw6490-eaaw6490, 2019; PubMed: 31555730; DOI: 10.1126/sciadv.aaw6490

Experimental method

ELECTRON MICROSCOPY (3.4 Å)