6RMG
Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein patched homolog 1,GFP-like fluorescent chromoprotein FP506, related | polymer | 1471 | 163846.7 | 1 | UniProt (Q13635) UniProt (U6GSR1) Pfam (PF02460) Pfam (PF01353) In PDB | Homo sapiens (Human) | PTC1 |
2 | B | Sonic hedgehog protein | polymer | 285 | 32397.5 | 1 | UniProt (Q15465) Pfam (PF01085) In PDB | Homo sapiens (Human) | SHH,HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC |
3 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
5 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 11 | Chemie (Y01) | |||
6 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 1 - 1189 (UniProt: Q13635)
A: 1202 - 1441 (UniProt: U6GSR1)
B: 21 - 197 (UniProt: Q15465)
PDB | External Database | Details |
---|---|---|
Ala 645 | Tyr 645 | conflict |
Ala 1189 | Gly 1189 | linker |
Ala 1190 | - | linker |
Ala 1191 | - | linker |
Leu 1192 | - | linker |
Glu 1193 | - | linker |
Val 1194 | - | linker |
Leu 1195 | - | linker |
Phe 1196 | - | linker |
Gln 1197 | - | linker |
Gly 1198 | - | linker |
Pro 1199 | - | linker |
Gly 1200 | - | linker |
Gly 1201 | - | linker |
PDB | External Database | Details |
---|---|---|
Gln 1270 | Met 70 | conflict |
Ala 1440 | Trp 240 | conflict |
Ser 1442 | - | expression tag |
Ala 1443 | - | expression tag |
Trp 1444 | - | expression tag |
Ser 1445 | - | expression tag |
His 1446 | - | expression tag |
Pro 1447 | - | expression tag |
Gln 1448 | - | expression tag |
Phe 1449 | - | expression tag |
Glu 1450 | - | expression tag |
Lys 1451 | - | expression tag |
Gly 1452 | - | expression tag |
Gly 1453 | - | expression tag |
Gly 1454 | - | expression tag |
Ser 1455 | - | expression tag |
Gly 1456 | - | expression tag |
Gly 1457 | - | expression tag |
Gly 1458 | - | expression tag |
Ser 1459 | - | expression tag |
Gly 1460 | - | expression tag |
Gly 1461 | - | expression tag |
Ser 1462 | - | expression tag |
Ala 1463 | - | expression tag |
Trp 1464 | - | expression tag |
Ser 1465 | - | expression tag |
His 1466 | - | expression tag |
Pro 1467 | - | expression tag |
Gln 1468 | - | expression tag |
Phe 1469 | - | expression tag |
Glu 1470 | - | expression tag |
Lys 1471 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -87 | - | initiating methionine |
Lys -86 | - | expression tag |
Lys -85 | - | expression tag |
His -84 | - | expression tag |
His -83 | - | expression tag |
His -82 | - | expression tag |
His -81 | - | expression tag |
His -80 | - | expression tag |
His -79 | - | expression tag |
Gly -78 | - | expression tag |
Ser -77 | - | expression tag |
Gly -76 | - | expression tag |
Met -75 | - | expression tag |
Ser -74 | - | expression tag |
Asp -73 | - | expression tag |
Ser -72 | - | expression tag |
Glu -71 | - | expression tag |
Val -70 | - | expression tag |
Asn -69 | - | expression tag |
Gln -68 | - | expression tag |
Glu -67 | - | expression tag |
Ala -66 | - | expression tag |
Lys -65 | - | expression tag |
Pro -64 | - | expression tag |
Glu -63 | - | expression tag |
Val -62 | - | expression tag |
Lys -61 | - | expression tag |
Pro -60 | - | expression tag |
Glu -59 | - | expression tag |
Val -58 | - | expression tag |
Lys -57 | - | expression tag |
Pro -56 | - | expression tag |
Glu -55 | - | expression tag |
Thr -54 | - | expression tag |
His -53 | - | expression tag |
Ile -52 | - | expression tag |
Asn -51 | - | expression tag |
Leu -50 | - | expression tag |
Lys -49 | - | expression tag |
Val -48 | - | expression tag |
Ser -47 | - | expression tag |
Asp -46 | - | expression tag |
Gly -45 | - | expression tag |
Ser -44 | - | expression tag |
Ser -43 | - | expression tag |
Glu -42 | - | expression tag |
Ile -41 | - | expression tag |
Phe -40 | - | expression tag |
Phe -39 | - | expression tag |
Lys -38 | - | expression tag |
Ile -37 | - | expression tag |
Lys -36 | - | expression tag |
Lys -35 | - | expression tag |
Thr -34 | - | expression tag |
Thr -33 | - | expression tag |
Pro -32 | - | expression tag |
Leu -31 | - | expression tag |
Arg -30 | - | expression tag |
Arg -29 | - | expression tag |
Leu -28 | - | expression tag |
Met -27 | - | expression tag |
Glu -26 | - | expression tag |
Ala -25 | - | expression tag |
Phe -24 | - | expression tag |
Ala -23 | - | expression tag |
Lys -22 | - | expression tag |
Arg -21 | - | expression tag |
Gln -20 | - | expression tag |
Gly -19 | - | expression tag |
Lys -18 | - | expression tag |
Glu -17 | - | expression tag |
Met -16 | - | expression tag |
Asp -15 | - | expression tag |
Ser -14 | - | expression tag |
Leu -13 | - | expression tag |
Arg -12 | - | expression tag |
Phe -11 | - | expression tag |
Leu -10 | - | expression tag |
Tyr -9 | - | expression tag |
Asp -8 | - | expression tag |
Gly -7 | - | expression tag |
Ile -6 | - | expression tag |
Arg -5 | - | expression tag |
Ile -4 | - | expression tag |
Gln -3 | - | expression tag |
Ala -2 | - | expression tag |
Asp -1 | - | expression tag |
Gln 0 | - | expression tag |
Thr 1 | - | expression tag |
Pro 2 | - | expression tag |
Glu 3 | - | expression tag |
Asp 4 | - | expression tag |
Leu 5 | - | expression tag |
Asp 6 | - | expression tag |
Met 7 | - | expression tag |
Glu 8 | - | expression tag |
Asp 9 | - | expression tag |
Asn 10 | - | expression tag |
Asp 11 | - | expression tag |
Ile 12 | - | expression tag |
Ile 13 | - | expression tag |
Glu 14 | - | expression tag |
Ala 15 | - | expression tag |
His 16 | - | expression tag |
Arg 17 | - | expression tag |
Glu 18 | - | expression tag |
Gln 19 | - | expression tag |
Ile 20 | - | expression tag |
Gly 22 | Leu 22 | conflict |
Ile 23 | Ala 23 | conflict |
Ile 24 | Cys 24 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 196244.2 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 6525.4 | |
All* | Total formula weight | 203194.1 |