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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6RMG

Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Protein patched homolog 1,GFP-like fluorescent chromoprotein FP506, relatedpolymer1471163846.71UniProt (Q13635)
UniProt (U6GSR1)
Pfam (PF12349)
Pfam (PF01353)		Homo sapiens (Human)PTC1
2B
(B)		Sonic hedgehog proteinpolymer28532397.51UniProt (Q15465)
Pfam (PF01085)		Homo sapiens (Human)SHH,HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC
3C
(C)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
4D, E, F, G, H
(A)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.25Chemie (NAG)
5I, J, K, L, M...
(A)		CHOLESTEROL HEMISUCCINATEnon-polymer486.711Chemie (Y01)
PubChem (16219150)
PubChem (22210610)
PubChem (65082)
PubChem (363416)
PubChem (45489984)
PubChem (500055)
PubChem (60078761)
PubChem (57163942)
PubChem (73440805)
PubChem (89891013)
PubChem (13301926)
PubChem (13301927)
PubChem (99567469)
PubChem (99567468)
PubChem (124427194)
PubChem (124897021)
PubChem (124897020)
PubChem (10005657)
PubChem (130340716)
PubChem (11969853)
PubChem (124301053)
PubChem (124302591)
PubChem (124303794)
PubChem (124421343)
PubChem (124427195)
PubChem (137392566)
PubChem (137496323)
PubChem (124914595)
PubChem (124914596)
PubChem (131705526)
PubChem (155804219)
PubChem (137332121)
PubChem (137496357)
PubChem (146157332)
PubChem (169132514)
PubChem (154929912)
PubChem (155199678)
PubChem (156327905)
PubChem (156426247)
PubChem (156516588)
PubChem (166979870)
PubChem (167024614)
PubChem (169132513)
PubChem (170117245)
PubChem (172400028)
6T
(B)		ZINC IONnon-polymer65.41Chemie (ZN)
Sequence modifications
A: 1 - 1189 (UniProt: Q13635)
PDBExternal DatabaseDetails
Ala 645Tyr 645conflict
Ala 1189Gly 1189linker
Ala 1190-linker
Ala 1191-linker
Leu 1192-linker
Glu 1193-linker
Val 1194-linker
Leu 1195-linker
Phe 1196-linker
Gln 1197-linker
Gly 1198-linker
Pro 1199-linker
Gly 1200-linker
Gly 1201-linker
A: 1202 - 1441 (UniProt: U6GSR1)
PDBExternal DatabaseDetails
Gln 1270Met 70conflict
Ala 1440Trp 240conflict
Ser 1442-expression tag
Ala 1443-expression tag
Trp 1444-expression tag
Ser 1445-expression tag
His 1446-expression tag
Pro 1447-expression tag
Gln 1448-expression tag
Phe 1449-expression tag
Glu 1450-expression tag
Lys 1451-expression tag
Gly 1452-expression tag
Gly 1453-expression tag
Gly 1454-expression tag
Ser 1455-expression tag
Gly 1456-expression tag
Gly 1457-expression tag
Gly 1458-expression tag
Ser 1459-expression tag
Gly 1460-expression tag
Gly 1461-expression tag
Ser 1462-expression tag
Ala 1463-expression tag
Trp 1464-expression tag
Ser 1465-expression tag
His 1466-expression tag
Pro 1467-expression tag
Gln 1468-expression tag
Phe 1469-expression tag
Glu 1470-expression tag
Lys 1471-expression tag
B: 21 - 197 (UniProt: Q15465)
PDBExternal DatabaseDetails
Met -87-initiating methionine
Lys -86-expression tag
Lys -85-expression tag
His -84-expression tag
His -83-expression tag
His -82-expression tag
His -81-expression tag
His -80-expression tag
His -79-expression tag
Gly -78-expression tag
Ser -77-expression tag
Gly -76-expression tag
Met -75-expression tag
Ser -74-expression tag
Asp -73-expression tag
Ser -72-expression tag
Glu -71-expression tag
Val -70-expression tag
Asn -69-expression tag
Gln -68-expression tag
Glu -67-expression tag
Ala -66-expression tag
Lys -65-expression tag
Pro -64-expression tag
Glu -63-expression tag
Val -62-expression tag
Lys -61-expression tag
Pro -60-expression tag
Glu -59-expression tag
Val -58-expression tag
Lys -57-expression tag
Pro -56-expression tag
Glu -55-expression tag
Thr -54-expression tag
His -53-expression tag
Ile -52-expression tag
Asn -51-expression tag
Leu -50-expression tag
Lys -49-expression tag
Val -48-expression tag
Ser -47-expression tag
Asp -46-expression tag
Gly -45-expression tag
Ser -44-expression tag
Ser -43-expression tag
Glu -42-expression tag
Ile -41-expression tag
Phe -40-expression tag
Phe -39-expression tag
Lys -38-expression tag
Ile -37-expression tag
Lys -36-expression tag
Lys -35-expression tag
Thr -34-expression tag
Thr -33-expression tag
Pro -32-expression tag
Leu -31-expression tag
Arg -30-expression tag
Arg -29-expression tag
Leu -28-expression tag
Met -27-expression tag
Glu -26-expression tag
Ala -25-expression tag
Phe -24-expression tag
Ala -23-expression tag
Lys -22-expression tag
Arg -21-expression tag
Gln -20-expression tag
Gly -19-expression tag
Lys -18-expression tag
Glu -17-expression tag
Met -16-expression tag
Asp -15-expression tag
Ser -14-expression tag
Leu -13-expression tag
Arg -12-expression tag
Phe -11-expression tag
Leu -10-expression tag
Tyr -9-expression tag
Asp -8-expression tag
Gly -7-expression tag
Ile -6-expression tag
Arg -5-expression tag
Ile -4-expression tag
Gln -3-expression tag
Ala -2-expression tag
Asp -1-expression tag
Gln 0-expression tag
Thr 1-expression tag
Pro 2-expression tag
Glu 3-expression tag
Asp 4-expression tag
Leu 5-expression tag
Asp 6-expression tag
Met 7-expression tag
Glu 8-expression tag
Asp 9-expression tag
Asn 10-expression tag
Asp 11-expression tag
Ile 12-expression tag
Ile 13-expression tag
Glu 14-expression tag
Ala 15-expression tag
His 16-expression tag
Arg 17-expression tag
Glu 18-expression tag
Gln 19-expression tag
Ile 20-expression tag
Gly 22Leu 22conflict
Ile 23Ala 23conflict
Ile 24Cys 24conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight196244.2
BranchedNumber of molecules1
Total formula weight424.4
Non-Polymers*Number of molecules17
Total formula weight6525.4
All*Total formula weight203194.1
*Water molecules are not included.

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PDB entries from 2026-04-01

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