6RMG
Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008158 | molecular_function | hedgehog receptor activity |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016020 | cellular_component | membrane |
| B | 0007267 | biological_process | cell-cell signaling |
| B | 0007275 | biological_process | multicellular organism development |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3MXW |
| Chain | Residue | Details |
| B | GLU89 | |
| B | GLU90 | |
| B | ASP95 | |
| B | THR125 | |
| B | GLU126 | |
| B | ASP129 | |
| B | ASP131 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10753901, ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3M1N, ECO:0007744|PDB:3MXW |
| Chain | Residue | Details |
| B | HIS140 | |
| A | VAL1084-PHE1104 | |
| A | MET1122-ALA1141 | |
| A | VAL1155-LEU1175 | |
| B | ASP147 | |
| B | HIS182 | |
| A | VAL502-PHE522 | |
| A | VAL548-PRO568 | |
| A | ALA578-MET598 | |
| A | ALA749-THR769 | |
| A | LEU1028-LEU1048 | |
| A | ILE1056-ILE1076 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:Q02936 |
| Chain | Residue | Details |
| B | GLY197 | |
| A | SER494-GLN501 | |
| A | ALA569-ALA577 | |
| A | ARG770-TRP1027 | |
| A | LYS1077-VAL1083 | |
| A | GLY1142-ALA1154 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | LIPID: N-palmitoyl cysteine => ECO:0000269|PubMed:18534984, ECO:0000269|PubMed:31875564, ECO:0000269|PubMed:9593755 |
| Chain | Residue | Details |
| B | ILE24 | |
| A | ASN312 | |
| A | ASN349 | |
| A | ASN414 | |
| A | ASN875 | |
| A | ASN1000 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | LIPID: Cholesterol glycine ester => ECO:0000250|UniProtKB:Q62226 |
| Chain | Residue | Details |
| B | GLY197 |
