2X2K
| Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | 分子名称: | (3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Knowles, P.P, Murray-Rust, J, Kjaer, S, McDonald, N.Q. | 登録日 | 2010-01-13 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg. Med. Chem., 18, 2010
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2X2M
| Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | 分子名称: | (3Z)-3-[(3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Knowles, P.P, Murray-Rust, J, Kjaer, S, McDonald, N.Q. | 登録日 | 2010-01-13 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg. Med. Chem., 18, 2010
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2X2L
| Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | 分子名称: | (3Z)-5-AMINO-3-[(4-METHOXYPHENYL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Knowles, P.P, Murray-Rust, J, Kjaer, S, McDonald, N.Q. | 登録日 | 2010-01-13 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg. Med. Chem., 18, 2010
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2XQN
| Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the N-Terminal domain of actin-like protein Arp7A | 分子名称: | ACTIN-LIKE PROTEIN 7A, ENABLED HOMOLOG, TESTIN, ... | 著者 | Knowles, P.P, Briggs, D.C, Murray-Rust, J, McDonald, N.Q. | 登録日 | 2010-09-03 | 公開日 | 2011-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. J. Biol. Chem., 286, 2011
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2IVS
| Crystal structure of non-phosphorylated RET tyrosine kinase domain | 分子名称: | 2',3'- cyclic AMP, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Knowles, P.P, Murray-Rust, J, McDonald, N.Q. | 登録日 | 2006-06-16 | 公開日 | 2006-08-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and Chemical Inhibition of the Ret Tyrosine Kinase Domain. J.Biol.Chem., 281, 2006
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2IVV
| Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor PP1 | 分子名称: | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR | 著者 | Knowles, P.P, Murray-Rust, J, McDonald, N.Q. | 登録日 | 2006-06-16 | 公開日 | 2006-08-14 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure and chemical inhibition of the RET tyrosine kinase domain. J. Biol. Chem., 281, 2006
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2IVU
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2IVT
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7AMK
| Zebrafish RET Cadherin Like Domains 1 to 4. | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Purkiss, A.G, McDonald, N.Q, Goodman, K.M, Narowtek, A, Knowles, P.P. | 登録日 | 2020-10-09 | 公開日 | 2021-02-03 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29, 2021
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2BGW
| XPF from Aeropyrum pernix, complex with DNA | 分子名称: | 5'-D(*GP*AP*TP*CP*AP*CP*AP*GP*AP*TP *GP*CP*TP*GP*A)-3', 5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*GP *TP*GP*AP*TP*C)-3', MAGNESIUM ION, ... | 著者 | Newman, M, Murray-Rust, J, Lally, J, Rudolf, J, Fadden, A, Knowles, P.P, White, M.F, McDonald, N.Q. | 登録日 | 2005-01-06 | 公開日 | 2005-02-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. EMBO J., 24, 2005
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3ZH8
| A novel small molecule aPKC inhibitor | 分子名称: | (2S)-3-phenyl-N~1~-[2-(pyridin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]propane-1,2-diamine, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Kjaer, S, Purkiss, A.G, Kostelecky, B, Knowles, P.P, Soriano, E, Murray-Rust, J, McDonald, N.Q. | 登録日 | 2012-12-20 | 公開日 | 2013-02-27 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.739 Å) | 主引用文献 | Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes. Biochem.J., 451, 2013
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1YZB
| Solution structure of the Josephin domain of Ataxin-3 | 分子名称: | Machado-Joseph disease protein 1 | 著者 | Nicastro, G, Masino, L, Menon, R.P, Knowles, P.P, McDonald, N.Q, Pastore, A. | 登録日 | 2005-02-28 | 公開日 | 2005-07-05 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition Proc.Natl.Acad.Sci.Usa, 102, 2005
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2BHN
| XPF from Aeropyrum pernix | 分子名称: | XPF ENDONUCLEASE | 著者 | Newman, M, Murray-Rust, J, Lally, J, Rudolf, J, Fadden, A, Knowles, P.P, White, M.F, McDonald, N.Q. | 登録日 | 2005-01-14 | 公開日 | 2005-02-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. EMBO J., 24, 2005
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2VT8
| Structure of a conserved dimerisation domain within Fbox7 and PI31 | 分子名称: | PROTEASOME INHIBITOR PI31 SUBUNIT | 著者 | Kirk, R.J, Murray-Rust, J, Knowles, P.P, Laman, H, McDonald, N.Q. | 登録日 | 2008-05-12 | 公開日 | 2008-05-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of a Conserved Dimerization Domain within the F-Box Protein Fbxo7 and the Pi31 Proteasome Inhibitor. J.Biol.Chem., 283, 2008
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