3ZH8
A novel small molecule aPKC inhibitor
Summary for 3ZH8
Entry DOI | 10.2210/pdb3zh8/pdb |
Descriptor | PROTEIN KINASE C IOTA TYPE, IODIDE ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | transferase, agc kinases, cell polarity, cell migration |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 3 |
Total formula weight | 124448.51 |
Authors | Kjaer, S.,Purkiss, A.G.,Kostelecky, B.,Knowles, P.P.,Soriano, E.,Murray-Rust, J.,McDonald, N.Q. (deposition date: 2012-12-20, release date: 2013-02-27, Last modification date: 2023-12-20) |
Primary citation | Kjaer, S.,Linch, M.,Purkiss, A.,Kostelecky, B.,Knowles, P.P.,Rosse, C.,Riou, P.,Soudy, C.,Kaye, S.,Patel, B.,Soriano, E.,Murray-Rust, J.,Barton, C.,Dillon, C.,Roffey, J.,Parker, P.J.,Mcdonald, N.Q. Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes. Biochem.J., 451:329-, 2013 Cited by PubMed: 23418854DOI: 10.1042/BJ20121871 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.739 Å) |
Structure validation
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