2IVT

Crystal structure of phosphorylated RET tyrosine kinase domain

Summary for 2IVT

Entry DOI	10.2210/pdb2ivt/pdb
Related	1XPD 2IVS 2IVU 2IVV
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR, FORMIC ACID, ADENOSINE MONOPHOSPHATE, ... (4 entities in total)
Functional Keywords	nucleotide-binding, hirschsprung disease, phosphorylation, disease mutation, phosphotransferase, tyrosine-protein kinase, chromosomal translocation, polymorphism, gdnf receptor, transmembrane, proto-oncogene, tyrosine kinase, ret, kinase, membrane, atp-binding, transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	36227.49
Authors	Knowles, P.P.,Murray-Rust, J.,McDonald, N.Q. (deposition date: 2006-06-16, release date: 2006-08-14, Last modification date: 2023-12-13)
Primary citation	Knowles, P.P.,Murray-Rust, J.,Kjaer, S.,Scott, R.P.,Hanrahan, S.,Santoro, M.,Ibanez, C.F.,McDonald, N.Q. Structure and chemical inhibition of the RET tyrosine kinase domain. J. Biol. Chem., 281:33577-33587, 2006 Cited by PubMed: 16928683 DOI: 10.1074/jbc.M605604200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation