2IVV
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor PP1
Summary for 2IVV
Entry DOI | 10.2210/pdb2ivv/pdb |
Related | 1XPD 2IVS 2IVT 2IVU |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR, FORMIC ACID, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, ... (4 entities in total) |
Functional Keywords | nucleotide-binding, hirschsprung disease, phosphorylation, disease mutation, phosphotransferase, tyrosine-protein kinase, chromosomal translocation, polymorphism, gdnf receptor, transmembrane, proto-oncogene, tyrosine kinase, ret, kinase, membrane, atp-binding, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36119.52 |
Authors | Knowles, P.P.,Murray-Rust, J.,McDonald, N.Q. (deposition date: 2006-06-16, release date: 2006-08-14, Last modification date: 2024-05-01) |
Primary citation | Knowles, P.P.,Murray-Rust, J.,Kjaer, S.,Scott, R.P.,Hanrahan, S.,Santoro, M.,Ibanez, C.F.,McDonald, N.Q. Structure and chemical inhibition of the RET tyrosine kinase domain. J. Biol. Chem., 281:33577-33587, 2006 Cited by PubMed: 16928683DOI: 10.1074/jbc.M605604200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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