2IVV
Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor PP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR | polymer | 314 | 35746.1 | 1 | UniProt (P07949) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | RET RECEPTOR, C-RET |
| 2 | B, C (A) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 3 | D (A) | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE | non-polymer | 281.4 | 1 | Chemie (PP1) | |||
| 4 | E (A) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 700 - 704 (PDB: 2IVV)
A: 705 - 1013 (UniProt: P07949)
A: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Ser 869 | Lys 869 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35746.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 373.4 | |
| All* | Total formula weight | 36119.5 |
