2QO3
 
 | | Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase | | Descriptor: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, ACETATE ION, ... | | Authors: | Khosla, C, Cane, E.D, Tang, Y, Chen, Y.A, Kim, C.Y. | | Deposit date: | 2007-07-19 | | Release date: | 2007-09-04 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase
Chem.Biol., 14, 2007
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3IIA
 | | Crystal structure of apo (91-244) RIa subunit of cAMP-dependent protein kinase | | Descriptor: | GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit | | Authors: | Sjoberg, T.J, Kim, C, Kornev, A.P, Taylor, S.S. | | Deposit date: | 2009-07-31 | | Release date: | 2010-08-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design.
Mol.Cell Proteomics, 10, 2011
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5BV8
 | | G1324S mutation in von Willebrand Factor A1 domain | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, von Willebrand factor | | Authors: | Campbell, J.C, Kim, C, Tischer, A, Auton, M. | | Deposit date: | 2015-06-04 | | Release date: | 2015-12-23 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Mutational Constraints on Local Unfolding Inhibit the Rheological Adaptation of von Willebrand Factor.
J.Biol.Chem., 291, 2016
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6BDL
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2L8E
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2FGG
 | | Crystal Structure of Rv2632c | | Descriptor: | Hypothetical protein Rv2632c/MT2708 | | Authors: | Yu, M, Bursey, E.H, Radhakannan, T, Segelke, B.W, Lekin, T, Toppani, D, Kim, C.Y, Kaviratne, T, Woodruff, T, Terwilliger, T.C, Hung, L.W, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2005-12-21 | | Release date: | 2006-02-14 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of Rv2632c
To be Published
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4RZM
 | | Crystal structure of the Lsd19-lasalocid A complex | | Descriptor: | CHLORIDE ION, Epoxide hydrolase LasB, FORMIC ACID, ... | | Authors: | Mathews, I.I, Hotta, K, Chen, X, Kim, C.-Y. | | Deposit date: | 2014-12-22 | | Release date: | 2015-01-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis.
J.Am.Chem.Soc., 137, 2015
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2A7Y
 | | Solution Structure of the Conserved Hypothetical Protein Rv2302 from the Bacterium Mycobacterium tuberculosis | | Descriptor: | Hypothetical protein Rv2302/MT2359 | | Authors: | Buchko, G.W, Kim, C.-Y, Terwilliger, T.C, Kennedy, M.A, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2005-07-06 | | Release date: | 2005-08-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the conserved hypothetical protein Rv2302 from Mycobacterium tuberculosis.
J.Bacteriol., 188, 2006
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1I4C
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6KU6
 | | OSM1 mutant - R326A | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Fumarate reductase 2, SUCCINIC ACID | | Authors: | Park, H.H, Kim, C.M. | | Deposit date: | 2019-08-30 | | Release date: | 2020-07-08 | | Method: | X-RAY DIFFRACTION (2.007 Å) | | Cite: | Crystal Structure of the Active Site Mutant Form of Soluble Fumarate Reductase, Osm1
Crystals, 2019
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4HPL
 | | PCGF1 Ub fold (RAWUL)/BCOR PUFD Complex | | Descriptor: | BCL-6 corepressor, Polycomb group RING finger protein 1 | | Authors: | Junco, S.E, Wang, R, Gaipa, J, Taylor, A.B, Gearhart, M.D, Bardwell, V.J, Hart, P.J, Kim, C.A. | | Deposit date: | 2012-10-24 | | Release date: | 2013-05-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the Polycomb Group Protein PCGF1 in Complex with BCOR Reveals Basis for Binding Selectivity of PCGF Homologs.
Structure, 21, 2013
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7UBO
 | | Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor CCD-956 | | Descriptor: | Bromodomain testis-specific protein, DIMETHYL SULFOXIDE, N-[(2R)-1-(methylamino)-3-{1-[(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)acetyl]piperidin-4-yl}-1-oxopropan-2-yl]-5-phenylpyridine-2-carboxamide | | Authors: | Ta, H.M, Modukuri, R.K, Yu, Z, Tan, Z, Matzuk, M.M, Kim, C. | | Deposit date: | 2022-03-15 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections.
Proc.Natl.Acad.Sci.USA, 119, 2022
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3J1Z
 | | Inward-Facing Conformation of the Zinc Transporter YiiP revealed by Cryo-electron Microscopy | | Descriptor: | Cation efflux family protein | | Authors: | Coudray, N, Valvo, S, Hu, M, Lasala, R, Kim, C, Vink, M, Zhou, M, Provasi, D, Filizola, M, Tao, J, Fang, J, Penczek, P.A, Ubarretxena-Belandia, I, Stokes, D.L, Transcontinental EM Initiative for Membrane Protein Structure (TEMIMPS) | | Deposit date: | 2012-07-24 | | Release date: | 2012-10-10 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (13 Å) | | Cite: | Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy.
Proc.Natl.Acad.Sci.USA, 110, 2013
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7L9A
 | | Crystal structure of BRDT bromodomain 2 in complex with CDD-1102 | | Descriptor: | BETA-MERCAPTOETHANOL, Bromodomain testis-specific protein, N~1~-(5-{[3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carbonyl]amino}-2-methylphenyl)-N~4~-methylbenzene-1,4-dicarboxamide | | Authors: | Sharma, R, Kaur, G, Yu, Z, Ku, A.F, Anglin, J.L, Ucisik, M.N, Faver, J.C, Sankaran, B, Kim, C, Matzuk, M.M. | | Deposit date: | 2021-01-03 | | Release date: | 2021-06-30 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Proc.Natl.Acad.Sci.USA, 118, 2021
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4NEC
 | | Conversion of a Disulfide Bond into a Thioacetal Group during Echinomycin Biosynthesis | | Descriptor: | 2-CARBOXYQUINOXALINE, ACETATE ION, Echinomycin, ... | | Authors: | Hotta, K, Keegan, R.M, Ranganathan, S, Fang, M, Bibby, J, Winn, M.D, Sato, M, Lian, M, Watanabe, K, Rigden, D.J, Kim, C.-Y. | | Deposit date: | 2013-10-29 | | Release date: | 2014-01-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis.
Angew.Chem.Int.Ed.Engl., 53, 2014
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2FVH
 | | Crystal Structure of Rv1848, a Urease Gamma Subunit UreA (Urea amidohydrolase), from Mycobacterium Tuberculosis | | Descriptor: | Urease gamma subunit | | Authors: | Bursey, E.H, Yu, M, TB Structural Genomics Consortium (TBSGC), Lekin, T, Rupp, B, Kim, C.Y, Rho, B.S, Terwilliger, T.C. | | Deposit date: | 2006-01-30 | | Release date: | 2006-02-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of Rv1848, a Urease Gamma Subunit UreA (Urea amidohydrolase), from Mycobacterium Tuberculosis
To be Published
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1W30
 | | PyrR of Mycobacterium Tuberculosis as a potential drug target | | Descriptor: | PYRR BIFUNCTIONAL PROTEIN | | Authors: | Kantardjieff, K.A, Vasquez, C, Castro, P, Warfel, N.N, Rho, B.-S, Lekin, T, Kim, C.-Y, Segelke, B.W, Terwilliger, T, Rupp, B, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2004-07-11 | | Release date: | 2004-09-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of Pyrr (Rv1379) from Mycobacterium Tuberculosis: A Persistence Gene and Protein Drug Target
Acta Crystallogr.,Sect.D, 61, 2005
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4QX5
 | | Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG agonist design | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, IODIDE ION, cGMP-dependent protein kinase 1 | | Authors: | Huang, G.Y, Gerlits, O.O, Blakeley, M.P, Sankaran, B, Kovalevsky, A.Y, Kim, C. | | Deposit date: | 2014-07-18 | | Release date: | 2014-11-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.318 Å) | | Cite: | Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.
Biochemistry, 53, 2014
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4O6G
 | | Rv3902c from M. tuberculosis | | Descriptor: | Uncharacterized protein | | Authors: | Reddy, B.G, Moates, D.B, Kim, H, Green, T.J, Kim, C, Terwilliger, T.J, Delucas, L.J, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2013-12-20 | | Release date: | 2014-03-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | 1.55 angstrom resolution X-ray crystal structure of Rv3902c from Mycobacterium tuberculosis.
Acta Crystallogr F Struct Biol Commun, 70, 2014
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3IM4
 | | Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2 | | Descriptor: | Dual specificity A kinase-anchoring protein 2, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit | | Authors: | Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. | | Deposit date: | 2009-08-09 | | Release date: | 2010-02-02 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.285 Å) | | Cite: | Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity
Structure, 18, 2010
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1U5H
 | | Structure of Citrate Lyase beta subunit from Mycobacterium tuberculosis | | Descriptor: | FORMIC ACID, citE | | Authors: | Goulding, C.W, Lekin, T, Kim, C.Y, Segelke, B, Terwilliger, T.C, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2004-07-27 | | Release date: | 2004-10-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function.
J.Mol.Biol., 365, 2007
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4HPM
 | | PCGF1 Ub fold (RAWUL)/BCORL1 PUFD Complex | | Descriptor: | BCL-6 corepressor-like protein 1, PHOSPHATE ION, Polycomb group RING finger protein 1 | | Authors: | Junco, S.E, Wang, R, Gaipa, J, Taylor, A.B, Gearhart, M.D, Bardwell, V.J, Hart, P.J, Kim, C.A. | | Deposit date: | 2012-10-24 | | Release date: | 2013-05-01 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of the Polycomb Group Protein PCGF1 in Complex with BCOR Reveals Basis for Binding Selectivity of PCGF Homologs.
Structure, 21, 2013
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3IM3
 | | Crystal structure of PKA RI alpha dimerization/docking domain | | Descriptor: | FORMIC ACID, cAMP-dependent protein kinase type I-alpha regulatory subunit | | Authors: | Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. | | Deposit date: | 2009-08-09 | | Release date: | 2010-02-02 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity
Structure, 18, 2010
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1U5V
 | | Structure of CitE complexed with triphosphate group of ATP form Mycobacterium tuberculosis | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, FORMIC ACID, citE | | Authors: | Goulding, C.W, Lerkin, T, Kim, C.Y, Segelke, B, Terwilliger, T, Eisenberg, E, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2004-07-28 | | Release date: | 2004-10-12 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of Mycobacterium tuberculosis citrate lyase beta subunit and its unusual triphosphate binding site
To be Published
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4R4L
 | | Crystal structure of wt cGMP dependent protein kinase I alpha (PKGI alpha) leucine zipper | | Descriptor: | HEXANE-1,6-DIOL, SULFATE ION, cGMP-dependent protein kinase 1 | | Authors: | Reger, A.S, Guo, E, Yang, M.P, Qin, L, Kim, C. | | Deposit date: | 2014-08-19 | | Release date: | 2015-09-23 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.245 Å) | | Cite: | Structures of cGMP-Dependent Protein Kinase (PKG) I alpha Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability.
Biochemistry, 54, 2015
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