4WFM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wfm by Molmil](/molmil-images/mine/4wfm) | Structure of the complete bacterial SRP Alu domain | Descriptor: | Bacillus subtilis small cytoplasmic RNA (scRNA),RNA, COBALT HEXAMMINE(III), MAGNESIUM ION | Authors: | Kempf, G, Wild, K, Sinning, I. | Deposit date: | 2014-09-15 | Release date: | 2014-10-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the complete bacterial SRP Alu domain. Nucleic Acids Res., 42, 2014
|
|
4WFL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wfl by Molmil](/molmil-images/mine/4wfl) | |
7QNO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qno by Molmil](/molmil-images/mine/7qno) | Crystal structure of ligand-free Danio rerio HDAC6 CD1 CD2 | Descriptor: | GLYCEROL, Histone deacetylase 6, POTASSIUM ION, ... | Authors: | Kempf, G, Langousis, G, Sanchez, J, Matthias, P. | Deposit date: | 2021-12-21 | Release date: | 2022-02-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Expression and Crystallization of HDAC6 Tandem Catalytic Domains. Methods Mol.Biol., 2589, 2023
|
|
5NIY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5niy by Molmil](/molmil-images/mine/5niy) | Signal recognition particle-docking protein FtsY | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Signal recognition particle-docking protein FtsY | Authors: | Kempf, G, Stjepanovic, G, Lapouge, K, Sinning, I. | Deposit date: | 2017-03-27 | Release date: | 2018-10-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Escherichia coli SRP Receptor Forms a Homodimer at the Membrane. Structure, 26, 2018
|
|
2M7X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2m7x by Molmil](/molmil-images/mine/2m7x) | Structural and Functional Analysis of Transmembrane Segment IV of the Salt Tolerance Protein Sod2 | Descriptor: | Na(+)/H(+) antiporter | Authors: | Ullah, A, Kemp, G, Lee, B, Alves, C, Young, H, Sykes, B.D, Fliegel, L. | Deposit date: | 2013-05-02 | Release date: | 2013-06-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Functional Analysis of Transmembrane Segment IV of the Salt Tolerance Protein Sod2. J.Biol.Chem., 288, 2013
|
|
4UE4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ue4 by Molmil](/molmil-images/mine/4ue4) | Structural basis for targeting and elongation arrest of Bacillus signal recognition particle | Descriptor: | 6S RNA, FTSQ SIGNAL SEQUENCE, SIGNAL RECOGNITION PARTICLE PROTEIN | Authors: | Beckert, B, Kedrov, A, Sohmen, D, Kempf, G, Wild, K, Sinning, I, Stahlberg, H, Wilson, D.N, Beckmann, R. | Deposit date: | 2014-12-15 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Translational Arrest by a Prokaryotic Signal Recognition Particle is Mediated by RNA Interactions. Nat.Struct.Mol.Biol., 22, 2015
|
|
4UE5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ue5 by Molmil](/molmil-images/mine/4ue5) | Structural basis for targeting and elongation arrest of Bacillus signal recognition particle | Descriptor: | 7S RNA, SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, ... | Authors: | Beckert, B, Kedrov, A, Sohmen, D, Kempf, G, Wild, K, Sinning, I, Stahlberg, H, Wilson, D.N, Beckmann, R. | Deposit date: | 2014-12-15 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Translational Arrest by a Prokaryotic Signal Recognition Particle is Mediated by RNA Interactions. Nat.Struct.Mol.Biol., 22, 2015
|
|
6Y5E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y5e by Molmil](/molmil-images/mine/6y5e) | Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex) | Descriptor: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-C, ... | Authors: | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2020-02-25 | Release date: | 2020-09-23 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
|
|
6YOV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yov by Molmil](/molmil-images/mine/6yov) | OCT4-SOX2-bound nucleosome - SHL+6 | Descriptor: | DNA (142-MER), Green fluorescent protein,POU domain, class 5, ... | Authors: | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2020-04-15 | Release date: | 2020-05-06 | Last modified: | 2020-07-08 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
|
|
6Y5D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y5d by Molmil](/molmil-images/mine/6y5d) | Structure of human cGAS (K394E) bound to the nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-A, ... | Authors: | Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2020-02-25 | Release date: | 2020-09-23 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural mechanism of cGAS inhibition by the nucleosome. Nature, 587, 2020
|
|
6T90
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6t90 by Molmil](/molmil-images/mine/6t90) | OCT4-SOX2-bound nucleosome - SHL-6 | Descriptor: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | Authors: | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-10-25 | Release date: | 2020-05-06 | Last modified: | 2020-07-08 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
|
|
6T93
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6t93 by Molmil](/molmil-images/mine/6t93) | Nucleosome with OCT4-SOX2 motif at SHL-6 | Descriptor: | DNA (153-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-10-25 | Release date: | 2020-05-06 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
|
|
8OSL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8osl by Molmil](/molmil-images/mine/8osl) | Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) | Descriptor: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... | Authors: | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. | Deposit date: | 2023-04-19 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
|
|
8OSK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8osk by Molmil](/molmil-images/mine/8osk) | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) | Descriptor: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | Authors: | Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-04-19 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
|
|
8OSJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8osj by Molmil](/molmil-images/mine/8osj) | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) | Descriptor: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | Authors: | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-04-19 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
|
|
7Q3E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q3e by Molmil](/molmil-images/mine/7q3e) | Structure of the mouse CPLANE-RSG1 complex | Descriptor: | Ciliogenesis and planar polarity effector 2, GUANOSINE-5'-TRIPHOSPHATE, Protein fuzzy homolog, ... | Authors: | Langousis, G, Cavadini, S, Kempf, G, Matthias, P. | Deposit date: | 2021-10-27 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structure of the ciliogenesis-associated CPLANE complex. Sci Adv, 8, 2022
|
|
7Q3D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q3d by Molmil](/molmil-images/mine/7q3d) | Structure of the human CPLANE complex | Descriptor: | Protein fuzzy homolog, Protein inturned, WD repeat-containing and planar cell polarity effector protein fritz homolog | Authors: | Langousis, G, Cavadini, S, Kempf, G, Matthias, P. | Deposit date: | 2021-10-27 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structure of the ciliogenesis-associated CPLANE complex. Sci Adv, 8, 2022
|
|
7OKQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7okq by Molmil](/molmil-images/mine/7okq) | Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex | Descriptor: | Cullin-4A, DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, ... | Authors: | Mohamed, W.I, Schenk, A.D, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2021-05-18 | Release date: | 2021-10-13 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (8.4 Å) | Cite: | The CRL4 DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state. Embo J., 40, 2021
|
|
8OTT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ott by Molmil](/molmil-images/mine/8ott) | MYC-MAX bound to a nucleosome at SHL+5.8 | Descriptor: | DNA (144-MER), Histone H2A type 1-B/E, Histone H2A type 1-K, ... | Authors: | Stoos, L, Michael, A.K, Kempf, G, Kater, L, Cavadini, S, Thoma, N. | Deposit date: | 2023-04-21 | Release date: | 2023-05-24 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
|
|
8OTS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ots by Molmil](/molmil-images/mine/8ots) | OCT4 and MYC-MAX co-bound to a nucleosome | Descriptor: | DNA (127-MER), Green fluorescent protein,POU domain, class 5, ... | Authors: | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. | Deposit date: | 2023-04-21 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
|
|
8BUF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8buf by Molmil](/molmil-images/mine/8buf) | Structure of DDB1 bound to Z12-engaged CDK12-cyclin K | Descriptor: | 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one, Cyclin-K, Cyclin-dependent kinase 12, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
|
|
8BUJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8buj by Molmil](/molmil-images/mine/8buj) | Structure of DDB1 bound to DS06-engaged CDK12-cyclin K | Descriptor: | (2~{R})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.62 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
|
|
8BU1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bu1 by Molmil](/molmil-images/mine/8bu1) | Structure of DDB1 bound to DS17-engaged CDK12-cyclin K | Descriptor: | (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
|
|
8BU9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bu9 by Molmil](/molmil-images/mine/8bu9) | Structure of DDB1 bound to roscovitine-engaged CDK12-cyclin K | Descriptor: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | Authors: | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
|
|
8BUO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8buo by Molmil](/molmil-images/mine/8buo) | Structure of DDB1 bound to DS24-engaged CDK12-cyclin K | Descriptor: | (2~{R})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.58 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
|
|