5H9F
 
 | | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution. | | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | | Deposit date: | 2015-12-28 | | Release date: | 2016-02-17 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
Nature, 530, 2016
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5H9E
 | | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution. | | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | | Deposit date: | 2015-12-28 | | Release date: | 2016-02-17 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.21 Å) | | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
Nature, 530, 2016
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6C27
 | | SAM-III riboswitch ON-state | | Descriptor: | COBALT HEXAMMINE(III), SAM-III riboswitch | | Authors: | Grigg, J.C, Price, I.R, Ke, A. | | Deposit date: | 2018-01-07 | | Release date: | 2019-01-09 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.601 Å) | | Cite: | Evidence for two-tiered conformation selection in the SAM-III riboswitch
To Be Published
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8G9U
 | | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | | Descriptor: | CRISPR-associated protein, Csd1 family, Csd2 family, ... | | Authors: | Hu, C, Nam, K.H, Ke, A. | | Deposit date: | 2023-02-22 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
Mol.Cell, 84, 2024
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8GAN
 | | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | | Descriptor: | Cas11, Cas5, Cas7, ... | | Authors: | Hu, C, Nam, K.H, Ke, A. | | Deposit date: | 2023-02-23 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
Mol.Cell, 84, 2024
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7R2K
 | | elongated Cascade complex from type I-A CRISPR-Cas system | | Descriptor: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | | Authors: | Hu, C, Ni, D, Nam, K.H, Terns, M, Stahlberg, H, Ke, A. | | Deposit date: | 2022-02-04 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural snapshots for an atypic type I CRISPR-Cas system
To Be Published
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7R21
 | | elongated Cascade complex from type I-A CRISPR-Cas system | | Descriptor: | Cas11a, Cas7a, CrRNA (62-MER), ... | | Authors: | Hu, C, Ni, D, Nam, K.H, Stahlberg, H, Terns, M, Ke, A. | | Deposit date: | 2022-02-04 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural snapshots for an atypic type I CRISPR-Cas system
To Be Published
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8GAM
 | | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | | Descriptor: | Cas11, Cas5, Cas7, ... | | Authors: | Hu, C, Nam, K.H, Ke, A. | | Deposit date: | 2023-02-23 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
Mol.Cell, 84, 2024
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5XVO
 | | E. fae Cas1-Cas2/prespacer/target ternary complex revealing DNA sampling and half-integration states | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | | Deposit date: | 2017-06-28 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017
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4JRC
 | | Distal Stem I region from G. kaustophilus glyQS T box RNA | | Descriptor: | Distal Stem I region of the glyQS T box leader RNA, MAGNESIUM ION | | Authors: | Grigg, J.C, Ke, A. | | Deposit date: | 2013-03-21 | | Release date: | 2013-04-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.673 Å) | | Cite: | T box RNA decodes both the information content and geometry of tRNA to affect gene expression.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3L7Z
 | | Crystal structure of the S. solfataricus archaeal exosome | | Descriptor: | Probable exosome complex RNA-binding protein 1, Probable exosome complex exonuclease 1, Probable exosome complex exonuclease 2, ... | | Authors: | Lu, C, Ding, F, Ke, A. | | Deposit date: | 2009-12-29 | | Release date: | 2010-06-23 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring.
Plos One, 5, 2010
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4MGM
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4MGN
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5U3G
 | | Structure of the Dickeya dadantii ykkC riboswitch bound to guanidinium | | Descriptor: | GUANIDINE, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Battaglia, R.A, Price, I.R, Ke, A. | | Deposit date: | 2016-12-02 | | Release date: | 2017-02-01 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for guanidine sensing by the ykkC family of riboswitches.
RNA, 23, 2017
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5XVP
 | | E. fae Cas1-Cas2/prespacer/target ternary complex revealing the fully integrated states | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(P*TP*TP*CP*TP*CP*CP*GP*AP*G)-3'), ... | | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | | Deposit date: | 2017-06-28 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017
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6C66
 | | CRISPR RNA-guided surveillance complex, pre-nicking | | Descriptor: | CRISPR-associated helicase, Cas3 family, CRISPR-associated protein, ... | | Authors: | Xiao, Y, Luo, M, Liao, M, Ke, A. | | Deposit date: | 2018-01-17 | | Release date: | 2018-06-27 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Structure basis for RNA-guided DNA degradation by Cascade and Cas3.
Science, 361, 2018
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8GAF
 | | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | | Descriptor: | Cas11, Cas5, Cas7, ... | | Authors: | Hu, C, Nam, K.H, Ke, A. | | Deposit date: | 2023-02-22 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
Mol.Cell, 84, 2024
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8G9S
 | | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | | Descriptor: | AcrIC8, Cas11, Cas5, ... | | Authors: | Hu, C, Nam, K.H, Ke, A. | | Deposit date: | 2023-02-22 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
Mol.Cell, 84, 2024
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8G9T
 | | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | | Descriptor: | AcrIC9, Cas11, Cas5, ... | | Authors: | Hu, C, Nam, K.H, Ke, A. | | Deposit date: | 2023-02-22 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
Mol.Cell, 84, 2024
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7MI5
 | | Asymmetrical PAM-Non PAM prespacer bound Cas4/Cas1/Cas2 complex | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (26-MER), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.57 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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7MI4
 | | Symmetrical PAM-PAM prespacer bound Cas4/Cas1/Cas2 complex | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (35-MER), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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7MI9
 | | Full integration complex of Cas1/Cas2 from Cas4-containing system | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (5'-D(P*CP*GP*GP*AP*AP*AP*AP*GP*AP*GP*CP*C)-3'), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.89 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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7MIB
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7MID
 | | Sub-complex of Cas4-Cas1-Cas2 bound PAM containing DNA | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (33-MER), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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5U0A
 | | CRISPR RNA-guided surveillance complex | | Descriptor: | CRISPR-associated protein, Cas5e family, Cse1 family, ... | | Authors: | Xiao, Y, Luo, M, Hayes, R.P, Kim, J, Ng, S, Ding, F, Liao, M, Ke, A. | | Deposit date: | 2016-11-23 | | Release date: | 2017-08-09 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.
Cell, 170, 2017
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