3NRX
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![BU of 3nrx by Molmil](/molmil-images/mine/3nrx) | Insights into anti-parallel microtubule crosslinking by PRC1, a conserved non-motor microtubule binding protein | Descriptor: | Protein regulator of cytokinesis 1 | Authors: | Kapoor, T.M, Subramanian, R, Wilson-Kubalek, E.M, Arthur, C.P, Bick, M.J, Campbell, E.A, Darst, S.A, Milligan, R.A. | Deposit date: | 2010-06-30 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein. Cell(Cambridge,Mass.), 142, 2010
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3NRY
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![BU of 3nry by Molmil](/molmil-images/mine/3nry) | Insights into anti-parallel microtubule crosslinking by PRC1, a conserved microtubule binding protein | Descriptor: | Protein regulator of cytokinesis 1 | Authors: | Kapoor, T.M, Subramanian, R, Wilson-Kubalek, E.M, Arthur, C.P, Bick, M.J, Campbell, E.A, Darst, S.A, Milligan, R.A. | Deposit date: | 2010-07-01 | Release date: | 2010-08-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein. Cell(Cambridge,Mass.), 142, 2010
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5IJ9
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![BU of 5ij9 by Molmil](/molmil-images/mine/5ij9) | Cryo EM density of microtubule assembled from human TUBB3-D417H mutant | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ti, S.C, Pamula, M.C, Howes, S.C, Duellberg, C, Cade, N.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M. | Deposit date: | 2016-03-01 | Release date: | 2016-04-20 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Dev.Cell, 37, 2016
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8VLS
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![BU of 8vls by Molmil](/molmil-images/mine/8vls) | Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form) | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | Deposit date: | 2024-01-12 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VOV
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![BU of 8vov by Molmil](/molmil-images/mine/8vov) | Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form) | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | Deposit date: | 2024-01-16 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VKU
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![BU of 8vku by Molmil](/molmil-images/mine/8vku) | Structure of VCP in complex with an ATPase activator (D2 domains only, hexameric form) | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | Deposit date: | 2024-01-09 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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6E7B
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![BU of 6e7b by Molmil](/molmil-images/mine/6e7b) | 13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Ti, S.C, Alushin, G.M, Kapoor, T.M. | Deposit date: | 2018-07-25 | Release date: | 2018-10-10 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability. Dev. Cell, 47, 2018
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6E7C
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![BU of 6e7c by Molmil](/molmil-images/mine/6e7c) | 14-pf 3-start GMPCPP-human alpha1B/beta2B microtubules | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Ti, S.C, Alushin, G.M, Kapoor, T.M. | Deposit date: | 2018-07-25 | Release date: | 2018-10-10 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability. Dev. Cell, 47, 2018
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5IJ0
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![BU of 5ij0 by Molmil](/molmil-images/mine/5ij0) | Cryo EM density of microtubule assembled from human TUBB3 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ti, S.-C, Pamula, M.C, Howes, S.C, Duellberg, C, Nicholas, C.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M. | Deposit date: | 2016-03-01 | Release date: | 2016-04-20 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Dev.Cell, 37, 2016
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5KMG
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![BU of 5kmg by Molmil](/molmil-images/mine/5kmg) | Near-atomic cryo-EM structure of PRC1 bound to the microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Kellogg, E.H, Howes, S, Ti, S.-C, Ramirez-Aportela, E, Kapoor, T.M, Chacon, P, Nogales, E. | Deposit date: | 2016-06-27 | Release date: | 2016-08-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Near-atomic cryo-EM structure of PRC1 bound to the microtubule. Proc.Natl.Acad.Sci.USA, 113, 2016
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8VA2
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![BU of 8va2 by Molmil](/molmil-images/mine/8va2) | |
8VRD
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![BU of 8vrd by Molmil](/molmil-images/mine/8vrd) | |
8VT7
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![BU of 8vt7 by Molmil](/molmil-images/mine/8vt7) | |
8VRK
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![BU of 8vrk by Molmil](/molmil-images/mine/8vrk) | |
8VRJ
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![BU of 8vrj by Molmil](/molmil-images/mine/8vrj) | |
4L6Y
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![BU of 4l6y by Molmil](/molmil-images/mine/4l6y) | Structure of the microtubule associated protein PRC1 (Protein Regulator of Cytokinesis 1) | Descriptor: | Protein regulator of cytokinesis 1 | Authors: | Subramanian, R, Ti, S, Tan, L, Darst, S.A, Kapoor, T.M. | Deposit date: | 2013-06-13 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.3015 Å) | Cite: | Marking and Measuring Single Microtubules by PRC1 and Kinesin-4. Cell(Cambridge,Mass.), 154, 2013
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4L3I
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![BU of 4l3i by Molmil](/molmil-images/mine/4l3i) | Structure of the microtubule associated protein PRC1 (Protein Regulator of Cytokinesis 1) | Descriptor: | Protein regulator of cytokinesis 1 | Authors: | Subramanian, R, Ti, S, Tan, L, Darst, S.A, Kapoor, T.M. | Deposit date: | 2013-06-06 | Release date: | 2013-07-17 | Last modified: | 2013-08-07 | Method: | X-RAY DIFFRACTION (3.6005 Å) | Cite: | Marking and Measuring Single Microtubules by PRC1 and Kinesin-4. Cell(Cambridge,Mass.), 154, 2013
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1NLP
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![BU of 1nlp by Molmil](/molmil-images/mine/1nlp) | STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | C-SRC, NL2 (MN8-MN1-PLPPLP) | Authors: | Feng, S, Kapoor, T.M, Shirai, F, Combs, A.P, Schreiber, S.L. | Deposit date: | 1996-08-04 | Release date: | 1997-01-27 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem.Biol., 3, 1996
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1NLO
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![BU of 1nlo by Molmil](/molmil-images/mine/1nlo) | STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | C-SRC, NL1 (MN7-MN2-MN1-PLPPLP) | Authors: | Feng, S, Kapoor, T.M, Shirai, F, Combs, A.P, Schreiber, S.L. | Deposit date: | 1996-08-04 | Release date: | 1997-01-27 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem.Biol., 3, 1996
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6OR5
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![BU of 6or5 by Molmil](/molmil-images/mine/6or5) | Full-length S. pombe Mdn1 in the presence of AMPPNP (ring region) | Descriptor: | Midasin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Chen, Z, Suzuki, H, Wang, A.C, DiMaio, F, Walz, T, Kapoor, T.M. | Deposit date: | 2019-04-29 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis. Cell, 175, 2018
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6ORB
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![BU of 6orb by Molmil](/molmil-images/mine/6orb) | Full-length S. pombe Mdn1 in the presence of ATP and Rbin-1 | Descriptor: | Midasin | Authors: | Chen, Z, Suzuki, H, Wang, A.C, DiMaio, F, Walz, T, Kapoor, T.M. | Deposit date: | 2019-04-29 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis. Cell, 175, 2018
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6P11
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![BU of 6p11 by Molmil](/molmil-images/mine/6p11) | Structure of spastin AAA domain (T692A mutant) in complex with JNJ-7706621 inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Drosophila melanogaster Spastin AAA domain, ... | Authors: | Pisa, R, Cupido, T, Kapoor, T.M. | Deposit date: | 2019-05-17 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins. Cell Chem Biol, 26, 2019
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6P10
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![BU of 6p10 by Molmil](/molmil-images/mine/6p10) | Structure of spastin AAA domain (N527C mutant) in complex with JNJ-7706621 inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Drosophila melanogaster Spastin AAA domain, ... | Authors: | Pisa, R, Cupido, T, Kapoor, T.M. | Deposit date: | 2019-05-17 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins. Cell Chem Biol, 26, 2019
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6P12
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![BU of 6p12 by Molmil](/molmil-images/mine/6p12) | Structure of spastin AAA domain (wild-type) in complex with diaminotriazole-based inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, Drosophila melanogaster Spastin AAA domain, ... | Authors: | Pisa, R, Cupido, T, Kapoor, T.M. | Deposit date: | 2019-05-17 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.94131851 Å) | Cite: | Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins. Cell Chem Biol, 26, 2019
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6P14
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![BU of 6p14 by Molmil](/molmil-images/mine/6p14) | Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form B) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, ACETATE ION, ... | Authors: | Pisa, R, Cupido, T, Kapoor, T.M. | Deposit date: | 2019-05-17 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.93001127 Å) | Cite: | Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins. Cell Chem Biol, 26, 2019
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