1KEQ
 
 | | Crystal Structure of F65A/Y131C Carbonic Anhydrase V, covalently modified with 4-chloromethylimidazole | | 分子名称: | 4-METHYLIMIDAZOLE, ACETIC ACID, F65A/Y131C-MI Carbonic Anhydrase V, ... | | 著者 | Jude, K.M, Wright, S.K, Tu, C, Silverman, D.N, Viola, R.E, Christianson, D.W. | | 登録日 | 2001-11-16 | | 公開日 | 2002-03-06 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
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6OEL
 | | Engineered Fab bound to IL-4 receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ... | | 著者 | Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C. | | 登録日 | 2019-03-27 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
J.Biol.Chem., 294, 2019
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6WDQ
 | | IL23/IL23R/IL12Rb1 signaling complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, ... | | 著者 | Jude, K.M, Ely, L.K, Glassman, C.R, Thomas, C, Spangler, J.B, Lupardus, P.J, Garcia, K.C. | | 登録日 | 2020-04-01 | | 公開日 | 2021-02-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell, 184, 2021
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2FOU
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2FOQ
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2FOV
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2FOY
 | | Human Carbonic Anhydrase I complexed with a two-prong inhibitor | | 分子名称: | Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER | | 著者 | Jude, K.M, Banerjee, A.L, Haldar, M.K, Manokaran, S, Roy, B, Mallik, S, Srivastava, D.K, Christianson, D.W. | | 登録日 | 2006-01-14 | | 公開日 | 2006-04-04 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
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2FOS
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8FFE
 | | Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | | 分子名称: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | | 著者 | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | | 登録日 | 2022-12-08 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-03-22 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8FRE
 | | Designed loop protein RBL4 | | 分子名称: | 1,2-ETHANEDIOL, RBL4 | | 著者 | Jude, K.M, Jiang, H, Baker, D, Garcia, K.C. | | 登録日 | 2023-01-06 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | De novo design of buttressed loops for sculpting protein functions.
Nat.Chem.Biol., 20, 2024
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8FRF
 | | Homodimeric designed loop protein RBL7_C2_3 | | 分子名称: | MALONATE ION, RBL7_C2_3 | | 著者 | Jude, K.M, Jiang, H, Baker, D, Garcia, K.C. | | 登録日 | 2023-01-06 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | De novo design of buttressed loops for sculpting protein functions.
Nat.Chem.Biol., 20, 2024
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8VSJ
 | | Engineered peptide-specific binder in complex with HLA-DR1/CLIP | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Class-II-associated invariant chain peptide, HLA class II histocompatibility antigen DR beta chain, ... | | 著者 | Jude, K.M, Yang, X, Du, H, Kassardjian, A, Julien, J.-P, Huang, P, Garcia, K.C. | | 登録日 | 2024-01-24 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.28 Å) | | 主引用文献 | Differentiating MHC-II antigens with a single loop
To Be Published
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8UOS
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8DA3
 | | Coevolved affibody-Z domain pair LL1.c1 | | 分子名称: | Affibody LL1.FILF, Immunoglobulin G-binding protein A, MALONATE ION, ... | | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | | 登録日 | 2022-06-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA9
 | | Coevolved affibody-Z domain pair LL2.c3 | | 分子名称: | Affibody LL2.FIIV, GLYCEROL, Immunoglobulin G-binding protein A, ... | | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | | 登録日 | 2022-06-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA5
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8DA8
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8DA4
 | | Coevolved affibody-Z domain pair LL1.c2 | | 分子名称: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | | 登録日 | 2022-06-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA6
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8DA7
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8DAC
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8DAA
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8DAB
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8DZ8
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5UTZ
 | | Human IL-2/Fab complex | | 分子名称: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | | 著者 | Jude, K.M, Garcia, K.C. | | 登録日 | 2017-02-15 | | 公開日 | 2018-07-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.747 Å) | | 主引用文献 | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat. Med., 24, 2018
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