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PDB: 112 件
6E3K
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BU of 6e3k by Molmil
Interferon gamma signalling complex with IFNGR1 and IFNGR2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jude, K.M, Mendoza, J.L, Garcia, K.C.
登録日2018-07-14
公開日2019-02-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6E3L
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BU of 6e3l by Molmil
Interferon gamma signalling complex with IFNGR1 and IFNGR2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ...
著者Jude, K.M, Mendoza, J.L, Garcia, K.C.
登録日2018-07-14
公開日2019-02-27
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
1KEQ
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BU of 1keq by Molmil
Crystal Structure of F65A/Y131C Carbonic Anhydrase V, covalently modified with 4-chloromethylimidazole
分子名称: 4-METHYLIMIDAZOLE, ACETIC ACID, F65A/Y131C-MI Carbonic Anhydrase V, ...
著者Jude, K.M, Wright, S.K, Tu, C, Silverman, D.N, Viola, R.E, Christianson, D.W.
登録日2001-11-16
公開日2002-03-06
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
6OEL
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BU of 6oel by Molmil
Engineered Fab bound to IL-4 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ...
著者Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C.
登録日2019-03-27
公開日2019-08-07
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
J.Biol.Chem., 294, 2019
5WB2
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BU of 5wb2 by Molmil
US28 bound to engineered chemokine CX3CL1.35 and nanobodies
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ...
著者Jude, K.M, Burg, J.S, Tsutsumi, N, Miles, T.F, Garcia, K.C.
登録日2017-06-27
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
Elife, 7, 2018
6WDQ
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BU of 6wdq by Molmil
IL23/IL23R/IL12Rb1 signaling complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, ...
著者Jude, K.M, Ely, L.K, Glassman, C.R, Thomas, C, Spangler, J.B, Lupardus, P.J, Garcia, K.C.
登録日2020-04-01
公開日2021-02-24
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell, 184, 2021
8DA3
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BU of 8da3 by Molmil
Coevolved affibody-Z domain pair LL1.c1
分子名称: Affibody LL1.FILF, Immunoglobulin G-binding protein A, MALONATE ION, ...
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.06 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DA9
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BU of 8da9 by Molmil
Coevolved affibody-Z domain pair LL2.c3
分子名称: Affibody LL2.FIIV, GLYCEROL, Immunoglobulin G-binding protein A, ...
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DA4
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BU of 8da4 by Molmil
Coevolved affibody-Z domain pair LL1.c2
分子名称: Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ...
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DA6
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BU of 8da6 by Molmil
Coevolved affibody-Z domain pair LL1.c5
分子名称: Affibody LL1.FIIM, Immunoglobulin G-binding protein A
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DA7
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BU of 8da7 by Molmil
Coevolved affibody-Z domain pair LL1.c6
分子名称: Immunoglobulin G-binding protein A, MALONATE ION, affibody LL1.FIFV
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.02 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DA5
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BU of 8da5 by Molmil
Coevolved affibody-Z domain pair LL1.c4
分子名称: GLYCEROL, Immunoglobulin G-binding protein A, affibody LL1.FIVM
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DA8
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BU of 8da8 by Molmil
Coevolved affibody-Z domain pair LL2.c1
分子名称: Affibody LL2.FIIK, GLYCEROL, Immunoglobulin G-binding protein A
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DAC
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BU of 8dac by Molmil
Coevolved affibody-Z domain pair LL2.c22
分子名称: Affibody LL2.FILV, GLYCEROL, Immunoglobulin G-binding protein A
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DAA
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BU of 8daa by Molmil
Coevolved affibody-Z domain pair LL2.c7
分子名称: Affibody LL2.FIVK, Immunoglobulin G-binding protein A, MALONATE ION
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8DAB
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BU of 8dab by Molmil
Coevolved affibody-Z domain pair LL2.c17
分子名称: Affibody LL2.IVVY, Immunoglobulin G-binding protein A
著者Jude, K.M, Yang, A, Garcia, K.C.
登録日2022-06-13
公開日2023-07-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.134 Å)
主引用文献Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
8FRE
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BU of 8fre by Molmil
Designed loop protein RBL4
分子名称: 1,2-ETHANEDIOL, RBL4
著者Jude, K.M, Jiang, H, Baker, D, Garcia, K.C.
登録日2023-01-06
公開日2024-04-17
最終更新日2024-08-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献De novo design of buttressed loops for sculpting protein functions.
Nat.Chem.Biol., 20, 2024
8FRF
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BU of 8frf by Molmil
Homodimeric designed loop protein RBL7_C2_3
分子名称: MALONATE ION, RBL7_C2_3
著者Jude, K.M, Jiang, H, Baker, D, Garcia, K.C.
登録日2023-01-06
公開日2024-04-17
最終更新日2024-08-07
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献De novo design of buttressed loops for sculpting protein functions.
Nat.Chem.Biol., 20, 2024
8DZ8
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BU of 8dz8 by Molmil
Neoleukin 4, a de novo designed IL-4 mimetic
分子名称: neoleukin-4
著者Jude, K.M, Spangler, J.B, Garcia, K.C.
登録日2022-08-06
公開日2023-03-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.972 Å)
主引用文献Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Nat.Chem.Biol., 19, 2023
8FFE
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BU of 8ffe by Molmil
Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide
分子名称: GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ...
著者Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C.
登録日2022-12-08
公開日2023-03-08
最終更新日2023-03-22
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
2FOY
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BU of 2foy by Molmil
Human Carbonic Anhydrase I complexed with a two-prong inhibitor
分子名称: Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER
著者Jude, K.M, Banerjee, A.L, Haldar, M.K, Manokaran, S, Roy, B, Mallik, S, Srivastava, D.K, Christianson, D.W.
登録日2006-01-14
公開日2006-04-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
8UOS
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BU of 8uos by Molmil
Designed IL-1R antagonist IL-1Rmb80
分子名称: GLYCEROL, IL-1Rmb80
著者Jude, K.M, Garcia, K.C.
登録日2023-10-20
公開日2024-08-28
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献De novo design of miniprotein antagonists of cytokine storm inducers.
Nat Commun, 15, 2024
2FOQ
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BU of 2foq by Molmil
Human Carbonic Anhydrase II complexed with two-prong inhibitors
分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ...
著者Jude, K.M, Christianson, D.W.
登録日2006-01-13
公開日2006-02-28
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
2FOU
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BU of 2fou by Molmil
Human Carbonic Anhydrase II complexed with two-prong inhibitors
分子名称: COPPER (II) ION, Carbonic Anhydrase II, GLYCEROL, ...
著者Jude, K.M, Christianson, D.W.
登録日2006-01-14
公開日2006-04-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (0.99 Å)
主引用文献Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
2FOV
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BU of 2fov by Molmil
Human Carbonic Anhydrase II complexed with two-prong inhibitors
分子名称: ACETONITRILE, COPPER (II) ION, Carbonic Anhydrase II, ...
著者Jude, K.M, Christianson, D.W.
登録日2006-01-14
公開日2006-04-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006

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