7PFO
 
 | | Core human replisome | | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ... | | Authors: | Jones, M.J, Yeeles, J.T.P. | | Deposit date: | 2021-08-11 | | Release date: | 2021-11-10 | | Last modified: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Embo J., 40, 2021
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7PLO
 | | H. sapiens replisome-CUL2/LRR1 complex | | Descriptor: | Cell division control protein 45 homolog, Claspin, Cullin-2, ... | | Authors: | Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M. | | Deposit date: | 2021-09-01 | | Release date: | 2021-11-10 | | Last modified: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
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8B9D
 | | Human replisome bound by Pol Alpha | | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA Molecule, ... | | Authors: | Jones, M.L, Yeeles, J.T.P. | | Deposit date: | 2022-10-05 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
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6SXB
 | | XPF-ERCC1 Cryo-EM Structure, DNA-Bound form | | Descriptor: | DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3'), DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3'), DNA excision repair protein ERCC-1, ... | | Authors: | Jones, M.L, Briggs, D.C, McDonald, N.Q. | | Deposit date: | 2019-09-25 | | Release date: | 2020-03-11 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.
Nat Commun, 11, 2020
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6SXA
 | | XPF-ERCC1 Cryo-EM Structure, Apo-form | | Descriptor: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF | | Authors: | Jones, M.L, Briggs, D.C, McDonald, N.Q. | | Deposit date: | 2019-09-25 | | Release date: | 2020-03-11 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.
Nat Commun, 11, 2020
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8B9C
 | | S. cerevisiae pol alpha - replisome complex | | Descriptor: | Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... | | Authors: | Jones, M.L, Yeeles, J.T.P. | | Deposit date: | 2022-10-05 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
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8B9B
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8B9A
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2TGD
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6M9I
 | | L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | | Descriptor: | Ice nucleation protein | | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | | Deposit date: | 2018-08-23 | | Release date: | 2019-03-27 | | Last modified: | 2024-03-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
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6M7M
 | | rac-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | | Descriptor: | L-GSTSTA from ice nucleation protein, inaZ, and its enantiomer, ... | | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | | Deposit date: | 2018-08-20 | | Release date: | 2019-04-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.101 Å) | | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
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6M9J
 | | Racemic-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | | Descriptor: | Ice nucleation protein | | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | | Deposit date: | 2018-08-23 | | Release date: | 2019-03-27 | | Last modified: | 2024-03-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
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7N2H
 | | X-Ray structure of a sequence variant of a repeat segment of the yeast prion New1p | | Descriptor: | prion New1p | | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.102 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2G
 | | MicroED structure of human CPEB3 segment(154-161) kinked polymorph phased by ARCIMBOLDO-BORGES | | Descriptor: | CPEB3 | | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.201 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2J
 | | MicroED structure of a mutant mammalian prion segment phased by ARCIMBOLDO-BORGES | | Descriptor: | prion protein | | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2F
 | | MicroED structure of human CPEB3 segment (154-161) straight polymorph phased by ARCIMBOLDO-BORGES | | Descriptor: | CPEB3 | | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.2 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2K
 | | MicroED structure of sequence variant of repeat segment of the yeast prion New1p phased by ARCIMBOLDO-BORGES | | Descriptor: | prion New1p | | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.301 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2I
 | | MicroED structure of human LECT2 (45-53) phased by ARCIMBOLDO-BORGES | | Descriptor: | LECT2 | | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.402 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2L
 | | MicroED structure of a mutant mammalian prion segment | | Descriptor: | prion protein | | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2D
 | | MicroED structure of human zinc finger protein 292 segment (534-542) phased by ARCIMBOLDO-BORGES | | Descriptor: | DIMETHYL SULFOXIDE, zinc finger protein 292 | | Authors: | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-28 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.503 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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7N2E
 | | MicroED structure of human CPEB3 segment (154-161) straight polymorph | | Descriptor: | CPEB3 | | Authors: | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | | Deposit date: | 2021-05-29 | | Release date: | 2022-06-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON CRYSTALLOGRAPHY (1 Å) | | Cite: | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
Acs Bio Med Chem Au, 3, 2023
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1Z3N
 | | Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom | | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, aldose reductase, {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID | | Authors: | Van Zandt, M.C, Jones, M.L, Gunn, D.E, Geraci, L.S, Jones, J.H, Sawicki, D.R, Sredy, J, Jacot, J.L, Dicioccio, A.T, Petrova, T, Mitschler, A, Podjarny, A.D. | | Deposit date: | 2005-03-14 | | Release date: | 2006-03-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications
J.Med.Chem., 48, 2005
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7AJR
 | | Virtual screening approach leading to the identification of a novel and tractable series of Pseudomonas aeruginosa elastase inhibitors | | Descriptor: | 2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-1,3-dihydroinden-2-yl]ethanoic acid, Keratinase KP2, SULFATE ION, ... | | Authors: | Leiris, S, Davies, D.T, Sprinsky, N, Castandet, J, Behria, L, Bodnarchuk, M.S, Sutton, J.M, Mullins, T.M.G, Jones, M.W, Forrest, A.K, Pallin, T.D, Karunakar, P, Martha, S.K, Parusharamulu, B, Ramula, R, Kotha, V, Pottabathini, N, Pothukanuri, S, Lemonnier, M, Everett, M. | | Deposit date: | 2020-09-29 | | Release date: | 2021-02-10 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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6EEX
 | | L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | | Descriptor: | L-GSTSTA from ice nucleaction protein, inaZ | | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | | Deposit date: | 2018-08-15 | | Release date: | 2019-04-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
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6UOS
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