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PDB: 6 results
1L6S
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Crystal Structure of Porphobilinogen Synthase Complexed with the Inhibitor 4,7-Dioxosebacic Acid
Descriptor: 4,7-DIOXOSEBACIC ACID, MAGNESIUM ION, PORPHOBILINOGEN SYNTHASE, ...
Authors:Jaffe, E.K, Kervinen, J, Martins, J, Stauffer, F, Neier, R, Wlodawer, A, Zdanov, A.
Deposit date:2002-03-13
Release date:2002-04-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Species-Specific Inhibition of Porphobilinogen Synthase by 4-Oxosebacic Acid
J.Biol.Chem., 277, 2002
1L6Y
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Crystal Structure of Porphobilinogen Synthase Complexed with the Inhibitor 4-Oxosebacic Acid
Descriptor: 4-OXODECANEDIOIC ACID, GLYCEROL, MAGNESIUM ION, ...
Authors:Jaffe, E.K, Kervinen, J, Martins, J, Stauffer, F, Neier, R, Wlodawer, A, Zdanov, A.
Deposit date:2002-03-14
Release date:2002-04-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Species-Specific Inhibition of Porphobilinogen Synthase by 4-Oxosebacic Acid
J.Biol.Chem., 277, 2002
6N1K
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Full-length human phenylalanine hydroxylase (PAH) in the resting state
Descriptor: CHLORIDE ION, FE (III) ION, Phenylalanine-4-hydroxylase
Authors:Arturo, E.C, Jaffe, E.K.
Deposit date:2018-11-08
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.057 Å)
Cite:Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium.
J.Biol.Chem., 294, 2019
5DEN
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The First Structure of a Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of an Auto-inhibited Tetramer
Descriptor: FE (III) ION, Phenylalanine-4-hydroxylase
Authors:Arturo, E.C, Loll, P.J, Jaffe, E.K.
Deposit date:2015-08-25
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.
Proc.Natl.Acad.Sci.USA, 113, 2016
1PV8
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Crystal structure of a low activity F12L mutant of human porphobilinogen synthase
Descriptor: 3-(2-AMINOETHYL)-4-(AMINOMETHYL)HEPTANEDIOIC ACID, Delta-aminolevulinic acid dehydratase, ZINC ION
Authors:Breinig, S, Kervinen, J, Stith, L, Wasson, A.S, Fairman, R, Wlodawer, A, Zdanov, A, Jaffe, E.K.
Deposit date:2003-06-26
Release date:2003-09-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.
Nat.Struct.Biol., 10, 2003
1I8J
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CRYSTAL STRUCTURE OF PORPHOBILINOGEN SYNTHASE COMPLEXED WITH THE INHIBITOR 4,7-DIOXOSEBACIC ACID
Descriptor: 4,7-DIOXOSEBACIC ACID, MAGNESIUM ION, PORPHOBILINOGEN SYNTHASE, ...
Authors:Kervinen, J, Jaffe, E.K, Stauffer, F, Neier, R, Wlodawer, A, Zdanov, A.
Deposit date:2001-03-14
Release date:2001-06-20
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.
Biochemistry, 40, 2001

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