1I8J
CRYSTAL STRUCTURE OF PORPHOBILINOGEN SYNTHASE COMPLEXED WITH THE INHIBITOR 4,7-DIOXOSEBACIC ACID
Summary for 1I8J
Entry DOI | 10.2210/pdb1i8j/pdb |
Descriptor | PORPHOBILINOGEN SYNTHASE, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | lyase, heme biosynthesis, magnesium, 4, 7-dioxosebacic acid |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 71715.08 |
Authors | Kervinen, J.,Jaffe, E.K.,Stauffer, F.,Neier, R.,Wlodawer, A.,Zdanov, A. (deposition date: 2001-03-14, release date: 2001-06-20, Last modification date: 2023-08-09) |
Primary citation | Kervinen, J.,Jaffe, E.K.,Stauffer, F.,Neier, R.,Wlodawer, A.,Zdanov, A. Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity. Biochemistry, 40:8227-8236, 2001 Cited by PubMed: 11444968DOI: 10.1021/bi010656k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report