1PV8
Crystal structure of a low activity F12L mutant of human porphobilinogen synthase
Summary for 1PV8
| Entry DOI | 10.2210/pdb1pv8/pdb |
| Descriptor | Delta-aminolevulinic acid dehydratase, ZINC ION, 3-(2-AMINOETHYL)-4-(AMINOMETHYL)HEPTANEDIOIC ACID, ... (4 entities in total) |
| Functional Keywords | porphobilinogen synthase, tetrapyrrole biosynthesis, reaction intermediate, lyase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 72972.77 |
| Authors | Breinig, S.,Kervinen, J.,Stith, L.,Wasson, A.S.,Fairman, R.,Wlodawer, A.,Zdanov, A.,Jaffe, E.K. (deposition date: 2003-06-26, release date: 2003-09-09, Last modification date: 2023-08-16) |
| Primary citation | Breinig, S.,Kervinen, J.,Stith, L.,Wasson, A.S.,Fairman, R.,Wlodawer, A.,Zdanov, A.,Jaffe, E.K. Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase. Nat.Struct.Biol., 10:757-763, 2003 Cited by PubMed: 12897770DOI: 10.1038/nsb963 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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