1PV8
Crystal structure of a low activity F12L mutant of human porphobilinogen synthase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Delta-aminolevulinic acid dehydratase | polymer | 330 | 36304.8 | 2 | UniProt (P13716) Pfam (PF00490) | Homo sapiens (human) | Porphobilinogen synthase, ALADH |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D (A) | 3-(2-AMINOETHYL)-4-(AMINOMETHYL)HEPTANEDIOIC ACID | non-polymer | 232.3 | 1 | Chemie (PB1) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 330 (UniProt: P13716)
| PDB | External Database | Details |
|---|---|---|
| Leu 12 | Phe 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72609.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 363.1 | |
| All* | Total formula weight | 72972.8 |
