4TVX
 
 | | Crystal structure of the E. coli CRISPR RNA-guided surveillance complex, Cascade | | 分子名称: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | | 著者 | Jackson, R.N, Golden, S.M, Carter, J, Wiedenheft, B. | | 登録日 | 2014-06-28 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | | 主引用文献 | Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli.
Science, 345, 2014
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6NJY
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5CD4
 | | The Type IE CRISPR Cascade complex from E. coli, with two assemblies in the asymmetric unit arranged back-to-back | | 分子名称: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | | 著者 | Jackson, R.N, Golden, S.M, Carter, J, Wiedenheft, B. | | 登録日 | 2015-07-03 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli.
Nucleic Acids Res., 43, 2015
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5O2T
 | | Human KRAS in complex with darpin K27 | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION, ... | | 著者 | Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. | | 登録日 | 2017-05-22 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun, 8, 2017
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2XNB
 | | Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents | | 分子名称: | 3,4-DIMETHYL-5-(2-{[(1Z)-4-PIPERAZIN-1-YLCYCLOHEXA-2,4-DIEN-1-YLIDENE]AMINO}PYRIMIDIN-4-YL)-1,3-THIAZOL-2(3H)-ONE, CELL DIVISION PROTEIN KINASE 2 | | 著者 | Wang, S, Griffiths, G, Midgley, C.A, Barnett, A.L, Cooper, M, Grabarek, J, Ingram, L, Jackson, W, Kontopidis, G, McClue, S.J, McInnes, C, McLachlan, J, Meades, C, Mezna, M, Stuart, I, Thomas, M.P, Zheleva, D.I, Lane, D.P, Jackson, R.C, Glover, D.M, Blake, D.G, Fischer, P.M. | | 登録日 | 2010-08-01 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
Chem.Biol., 17, 2010
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2XMY
 | | Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents | | 分子名称: | 4-[4-(3,4-DIMETHYL-2-OXO-2,3-DIHYDRO-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-N-(2-METHOXY-ETHYL)-BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 | | 著者 | Wang, S, Griffiths, G, Midgley, C.A, Barnett, A.L, Cooper, M, Grabarek, J, Ingram, L, Jackson, W, Kontopidis, G, McClue, S.J, McInnes, C, McLachlan, J, Meades, C, Mezna, M, Stuart, I, Thomas, M.P, Zheleva, D.I, Lane, D.P, Jackson, R.C, Glover, D.M, Blake, D.G, Fischer, P.M. | | 登録日 | 2010-07-29 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
Chem.Biol., 17, 2010
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5MLB
 | | Crystal structure of human RAS in complex with darpin K27 | | 分子名称: | DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. | | 登録日 | 2016-12-06 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
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5MLA
 | | Crystal structure of human RAS in complex with darpin K55 | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION, ... | | 著者 | Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. | | 登録日 | 2016-12-06 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Inhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
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5O2S
 | | Human KRAS in complex with darpin K27 | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. | | 登録日 | 2017-05-22 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun, 8, 2017
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8V44
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4HJ0
 | | Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution | | 分子名称: | Gastric inhibitory polypeptide receptor, Gipg013 Fab, Antagonizing antibody to the GIP Receptor, ... | | 著者 | Madhurantakam, C, Ravn, P, Gruetter, M.G, Jackson, R.H. | | 登録日 | 2012-10-12 | | 公開日 | 2013-05-29 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor.
J.Biol.Chem., 288, 2013
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2WIY
 | | Cytochrome P450 XplA heme domain P21212 | | 分子名称: | 1,2-ETHANEDIOL, CYTOCHROME P450-LIKE PROTEIN XPLA, IMIDAZOLE, ... | | 著者 | Sabbadin, F, Jackson, R, Bruce, N.C, Grogan, G. | | 登録日 | 2009-05-18 | | 公開日 | 2009-08-18 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | The 1.5-A Structure of Xpla-Heme, an Unusual Cytochrome P450 Heme Domain that Catalyzes Reductive Biotransformation of Royal Demolition Explosive.
J.Biol.Chem., 284, 2009
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2WIV
 | | Cytochrome-P450 XplA heme domain P21 | | 分子名称: | CYTOCHROME P450-LIKE PROTEIN XPLA, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sabbadin, F, Jackson, R, Bruce, N.C, Grogan, G. | | 登録日 | 2009-05-18 | | 公開日 | 2009-08-18 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The 1.5-A Structure of Xpla-Heme, an Unusual Cytochrome P450 Heme Domain that Catalyzes Reductive Biotransformation of Royal Demolition Explosive.
J.Biol.Chem., 284, 2009
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8E2W
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3BUX
 | | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | | 分子名称: | 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL | | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | | 登録日 | 2008-01-03 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
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3BUW
 | | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk | | 分子名称: | 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL | | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | | 登録日 | 2008-01-03 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
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3BUO
 | | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' | | 分子名称: | 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL | | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | | 登録日 | 2008-01-03 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
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3BUN
 | | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 | | 分子名称: | 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL | | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | | 登録日 | 2008-01-03 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
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5UZ9
 | | Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex | | 分子名称: | Anti-CRISPR protein 30, Anti-CRISPR protein Acr30-35, CRISPR RNA (60-MER), ... | | 著者 | Chowdhury, S, Carter, J, Rollins, M.F, Jackson, R.N, Hoffmann, C, Nosaka, L, Bondy-Denomy, J, Maxwell, K.L, Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B. | | 登録日 | 2017-02-25 | | 公開日 | 2017-04-26 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.
Cell, 169, 2017
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