5MLA
Crystal structure of human RAS in complex with darpin K55
Summary for 5MLA
Entry DOI | 10.2210/pdb5mla/pdb |
Descriptor | GTPase KRas, darpin k55, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | ras, darpin, nucleotide exchange, inhibition, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 2 |
Total formula weight | 40407.30 |
Authors | Debreczeni, J.E.,Guillard, S.,Kolasinska-Zwierz, P.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Mistry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. (deposition date: 2016-12-06, release date: 2017-12-20, Last modification date: 2024-05-08) |
Primary citation | Guillard, S.,Kolasinska-Zwierz, P.,Debreczeni, J.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Minstry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. Inhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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