5MLB
Crystal structure of human RAS in complex with darpin K27
Summary for 5MLB
Entry DOI | 10.2210/pdb5mlb/pdb |
Descriptor | GTPase KRas, DARPin K27, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | ras, darpin, nucleotide exchange, inhibition, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 8 |
Total formula weight | 156828.29 |
Authors | Debreczeni, J.E.,Guillard, S.,Kolasinska-Zwierz, P.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Mistry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. (deposition date: 2016-12-06, release date: 2017-12-20) |
Primary citation | Guillard, S.,Kolasinska-Zwierz, P.,Debreczeni, J.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Minstry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.22 Å) |
Structure validation
Download full validation report