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5MLB

Crystal structure of human RAS in complex with darpin K27

Summary for 5MLB
Entry DOI10.2210/pdb5mlb/pdb
DescriptorGTPase KRas, DARPin K27, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordsras, darpin, nucleotide exchange, inhibition, hydrolase
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
Total number of polymer chains8
Total formula weight156828.29
Authors
Primary citationGuillard, S.,Kolasinska-Zwierz, P.,Debreczeni, J.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Minstry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R.
INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.22 Å)
Structure validation

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PDB entries from 2024-03-27

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