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PDB: 3296 件
5WCA
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BU of 5wca by Molmil
Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 27-1C08 Fab.
分子名称: VRC315 27-1C08 Fab Heavy chain, VRC315 27-1C08 Fab Light chain
著者Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D.
登録日2017-06-29
公開日2017-08-02
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.369 Å)
主引用文献Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Sci Immunol, 2, 2017
1PZO
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BU of 1pzo by Molmil
TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor
分子名称: Beta-lactamase TEM, N,N-BIS(4-CHLOROBENZYL)-1H-1,2,3,4-TETRAAZOL-5-AMINE
著者Horn, J.R, Shoichet, B.K.
登録日2003-07-14
公開日2004-03-09
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allosteric inhibition through core disruption.
J.Mol.Biol., 336, 2004
5NA0
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BU of 5na0 by Molmil
TTK kinase domain in complex with a PEG-linked pyrimido-indolizine
分子名称: Dual specificity protein kinase TTK, ~{N}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide
著者Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R.
登録日2017-02-27
公開日2017-05-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5UMS
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BU of 5ums by Molmil
Crystal structure of middle double PH domain of human FACT complex subunit SSRP1
分子名称: FACT complex subunit SSRP1
著者Su, D, Hu, Q, Thompson, J.R, Botuyan, M.V, Mer, G.
登録日2017-01-29
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.569 Å)
主引用文献Crystal structure of middle double PH domain of human FACT complex subunit SSRP1
To Be Published
1PZP
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BU of 1pzp by Molmil
TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor
分子名称: 3-(4-PHENYLAMINO-PHENYLAMINO)-2-(1H-TETRAZOL-5-YL)-ACRYLONITRILE, Beta-lactamase TEM
著者Horn, J.R, Shoichet, B.K.
登録日2003-07-14
公開日2004-03-09
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Allosteric inhibition through core disruption.
J.Mol.Biol., 336, 2004
5UMV
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BU of 5umv by Molmil
Crystal structure of the BRCT domain of S. cerevisiae Rev1
分子名称: DNA repair protein REV1
著者Lee, J, Xu, C, Thompson, J.R, Botuyan, M.V, Mer, G.
登録日2017-01-29
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of the BRCT domain of S. cerevisiae Rev1
To Be Published
1ONH
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BU of 1onh by Molmil
GC1 beta-lactamase with a penem inhibitor
分子名称: 7-(5,6-DIHYDRO-8H-IMIDAZO[2,1-C][1,4]OXAZIN-2-YL)-6-FORMYL-2,7-DIHYDRO- [1,4]THIAZEPINE-3-CARBOXYLIC ACID, GLYCEROL, class C beta-lactamase
著者Nukaga, M, Nukaga, K, Knox, J.R.
登録日2003-02-27
公開日2003-12-09
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Inhibition of Class A and Class C Beta-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate
Biochemistry, 42, 2003
5UOT
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BU of 5uot by Molmil
CryoEM structure of the helical assembly of full length MxB
分子名称: Interferon-induced GTP-binding protein Mx2
著者Perilla, J.R, Alvarez, F.J.D, Zhang, P, Schulten, K.
登録日2017-02-01
公開日2018-02-21
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.
Sci Adv, 3, 2017
5WS6
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BU of 5ws6 by Molmil
Native XFEL structure of Photosystem II (preflash two-flash dataset
分子名称: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ...
著者Suga, M, Shen, J.R.
登録日2016-12-05
公開日2017-03-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL.
Nature, 543, 2017
5WCH
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BU of 5wch by Molmil
Crystal structure of the catalytic domain of human USP9X
分子名称: Probable ubiquitin carboxyl-terminal hydrolase FAF-X, UNKNOWN ATOM OR ION, ZINC ION
著者Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
登録日2017-06-30
公開日2018-07-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5TBV
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BU of 5tbv by Molmil
Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase complexed with tubercidin
分子名称: '2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, DIMETHYL SULFOXIDE, Purine nucleoside phosphorylase, ...
著者Faheem, M, Torini, J.R, Romanello, L, Brandao-Neto, J, Pereira, H.M.
登録日2016-09-13
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase
To Be Published
5WCD
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BU of 5wcd by Molmil
Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 04-1D02 Fab.
分子名称: PHOSPHATE ION, SULFATE ION, VRC315 04-1D02 Fab Heavy chain, ...
著者Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D.
登録日2017-06-29
公開日2017-08-23
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (1.814 Å)
主引用文献Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Sci Immunol, 2, 2017
5TF8
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BU of 5tf8 by Molmil
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dTTP
分子名称: Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE
著者Wang, C, Aleksandrov, A.A, Yang, Z, Forouhar, F, Proctor, E, Kota, P, An, J, Kaplan, A, Khazanov, N, Boel, G, Stockwell, B.R, Senderowitz, H, Dokholyan, N.V, Riordan, J.R, Brouillette, C.G, Hunt, J.F.
登録日2016-09-24
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.861 Å)
主引用文献Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFJ
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BU of 5tfj by Molmil
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
著者Wang, C, Aleksandrov, A.A, Yang, Z, Forouhar, F, Proctor, E, Kota, P, An, J, Kaplan, A, Khazanov, N, Boel, G, Stockwell, B.R, Senderowitz, H, Dokholyan, N.V, Riordan, J.R, Brouillette, C.G, Hunt, J.F.
登録日2016-09-25
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5N87
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BU of 5n87 by Molmil
TTK kinase domain in complex with NTRC 0066-0
分子名称: 2,5,8,11-TETRAOXATRIDECANE, Dual specificity protein kinase TTK, SODIUM ION, ...
著者Uitdehaag, J, Willemsen-Seegers, N, Sterrenburg, J.G, de Man, J, Buijsman, R.C, Zaman, G.J.R.
登録日2017-02-23
公開日2017-05-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5T7F
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BU of 5t7f by Molmil
PI3Kdelta in complex with the inhibitor GS-643624
分子名称: 2,4-bis(azanyl)-6-[[(1~{S})-1-[5-chloranyl-3-(5-fluoranyl-4-methyl-pyridin-3-yl)-4-oxidanylidene-quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Somoza, J.R, Villasenor, A.
登録日2016-09-04
公開日2016-12-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd
To Be Published
5TBU
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BU of 5tbu by Molmil
Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase complexed with Hypoxanthine
分子名称: DIMETHYL SULFOXIDE, HYPOXANTHINE, Purine nucleoside phosphorylase
著者Faheem, M, Torini, J.R, Romanello, L, Brandao-Neto, J, Pereira, H.M.
登録日2016-09-13
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.
PLoS ONE, 13, 2018
1OS7
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BU of 1os7 by Molmil
Crystal structure of TauD with iron, alpha-ketoglutarate and Taurine bound at pH 7.5
分子名称: 2-AMINOETHANESULFONIC ACID, 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent taurine dioxygenase, ...
著者O'Brien, J.R, Schuller, D.J, Yang, V.S, Dillard, B.D, Lanzilotta, W.N.
登録日2003-03-18
公開日2003-09-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Substrate-Induced Conformational Changes in Escherichia coli Taurine/alpha-Ketoglutarate Dioxygenase and Insight Into the Oligomeric Structure
Biochemistry, 42, 2003
5NBJ
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BU of 5nbj by Molmil
DLS Tetragonal - ReHEWL
分子名称: CHLORIDE ION, Lysozyme C, RHENIUM, ...
著者Brink, A, Helliwell, J.R.
登録日2017-03-02
公開日2017-05-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.266 Å)
主引用文献New leads for fragment-based design of rhenium/technetium radiopharmaceutical agents.
IUCrJ, 4, 2017
5Z01
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BU of 5z01 by Molmil
Native Escherichia coli L,D-carboxypeptidase A (LdcA)
分子名称: MAGNESIUM ION, Murein tetrapeptide carboxypeptidase
著者Meyer, K, Tame, J.R.H.
登録日2017-12-18
公開日2018-04-25
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The crystal structure and oligomeric form of Escherichia colil,d-carboxypeptidase A.
Biochem. Biophys. Res. Commun., 499, 2018
6BKE
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BU of 6bke by Molmil
BTK complex with compound 10
分子名称: N-[2-(2-hydroxyethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide, SULFATE ION, Tyrosine-protein kinase BTK
著者Kiefer, J.R, Eigenbrot, C, Yu, C.L, Wang, G.X.
登録日2017-11-08
公開日2018-11-07
最終更新日2019-03-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison.
J. Comput. Aided Mol. Des., 33, 2019
7LVT
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BU of 7lvt by Molmil
Structure of full-length GluK1 with L-Glu
分子名称: Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
著者Meyerson, J.R, Selvakumar, P.
登録日2021-02-26
公開日2021-11-03
最終更新日2021-11-10
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural and compositional diversity in the kainate receptor family.
Cell Rep, 37, 2021
6BIK
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BTK complex with compound 7
分子名称: 4-tert-butyl-N-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridazin-3-yl)phenyl]benzamide, GLYCEROL, SULFATE ION, ...
著者Kiefer, J.R, Eigenbrot, C, Yu, C.L.
登録日2017-11-02
公開日2018-11-07
最終更新日2019-03-27
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison.
J. Comput. Aided Mol. Des., 33, 2019
1O2I
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Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
分子名称: 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-6-(CYCLOPENTYLOXY)BENZENOLATE, BETA-TRYPSIN, CALCIUM ION, ...
著者Katz, B.A, Elrod, K, Verner, E, Mackman, R.L, Luong, C, Shrader, W, Sendzik, M, Spencer, J.R, Sprengeler, P.A, Kolesnikov, A, Tai, W.F, Hui, H, Breitenbucher, G, Allen, D, Janc, J.
登録日2003-03-06
公開日2003-05-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
J.Mol.Biol., 329, 2003
1O2N
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Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
分子名称: 3-{5-[AMINO(IMINIO)METHYL]-6-CHLORO-1H-BENZIMIDAZOL-2-YL}-1,1'-BIPHENYL-2-OLATE, BETA-TRYPSIN, CALCIUM ION, ...
著者Katz, B.A, Elrod, K, Verner, E, Mackman, R.L, Luong, C, Shrader, W, Sendzik, M, Spencer, J.R, Sprengeler, P.A, Kolesnikov, A, Tai, W.F, Hui, H, Breitenbucher, G, Allen, D, Janc, J.
登録日2003-03-06
公開日2003-05-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
J.Mol.Biol., 329, 2003

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