1ONH

GC1 beta-lactamase with a penem inhibitor

Summary for 1ONH

• Entry DOI: 10.2210/pdb1onh/pdb
• Related: 1GAO 1GCE 1ONG
• Descriptor: class C beta-lactamase, 7-(5,6-DIHYDRO-8H-IMIDAZO[2,1-C][1,4]OXAZIN-2-YL)-6-FORMYL-2,7-DIHYDRO- [1,4]THIAZEPINE-3-CARBOXYLIC ACID, GLYCEROL, ... (4 entities in total)
• Functional Keywords: mixed alpha/beta, cephalosporinase, inhibition, class c beta-lactamase, hydrolase
• Biological source: Enterobacter cloacae
• Total number of polymer chains: 1
• Total formula weight: 40284.87

Authors

Nukaga, M.,Nukaga, K.,Knox, J.R. (deposition date: 2003-02-27, release date: 2003-12-09, Last modification date: 2023-08-16)

• Primary citation: Nukaga, M.,Abe, T.,Venkatesan, A.M.,Mansour, T.S.,Bonomo, R.A.,Knox, J.R.; Inhibition of Class A and Class C Beta-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate; Biochemistry, 42:13152-13159, 2003; PubMed: 14609325; DOI: 10.1021/bi034986b

Experimental method

X-RAY DIFFRACTION (1.38 Å)