7BBC
 
 | | Joint X-ray/neutron room temperature structure of perdeuterated PLL lectin in complex with perdeuterated L-fucose | | 分子名称: | PLL lectin, alpha-L-fucopyranose, beta-L-fucopyranose | | 著者 | Gajdos, L, Blakeley, M.P, Kumar, A, Wimmerova, M, Haertlein, M, Forsyth, V.T, Imberty, A, Devos, J.M. | | 登録日 | 2020-12-17 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-05-01 | | 実験手法 | NEUTRON DIFFRACTION (1.84 Å), X-RAY DIFFRACTION | | 主引用文献 | Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions.
Structure, 29, 2021
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3KPD
 | | Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine. | | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, S-ADENOSYLMETHIONINE, Uncharacterized protein MJ0100 | | 著者 | Lucas, M, Oyenarte, I, Garcia, I.G, Arribas, E.A, Encinar, J.A, Kortazar, D, Fernandez, J.A, Mato, J.M, Martinez-Chantar, M.L, Martinez-Cruz, L.A. | | 登録日 | 2009-11-16 | | 公開日 | 2010-01-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Binding of S-Methyl-5'-Thioadenosine and S-Adenosyl-l-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair.
J.Mol.Biol., 396, 2010
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3KNR
 | | Bacillus cereus metallo-beta-lactamase Cys221Asp mutant, 1 mM Zn(II) | | 分子名称: | ACETIC ACID, Beta-lactamase 2, GLYCEROL, ... | | 著者 | Medrano Martin, F.J, Gonzalez, J.M, Vila, A.J. | | 登録日 | 2009-11-12 | | 公開日 | 2010-11-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions.
Nat.Chem.Biol., 8, 2012
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8QBF
 | | Compact state - Pil1 dimer with lipid headgroups fitted in native eisosome lattice bound to plasma membrane microdomain | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, PHOSPHOSERINE, Sphingolipid long chain base-responsive protein PIL1 | | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | | 登録日 | 2023-08-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Nature, 632, 2024
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8QB8
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8QB7
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3KPB
 | | Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine. | | 分子名称: | GLYCEROL, S-ADENOSYLMETHIONINE, Uncharacterized protein MJ0100 | | 著者 | Lucas, M, Oyenarte, I, Garcia, I.G, Arribas, E.A, Encinar, J.A, Kortazar, D, Fernandez, J.A, Mato, J.M, Martinez-Cruz, L.A. | | 登録日 | 2009-11-16 | | 公開日 | 2010-01-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Binding of S-Methyl-5'-Thioadenosine and S-Adenosyl-l-Methionine to Protein MJ0100 Triggers an Open-to-Closed Conformational Change in Its CBS Motif Pair.
J.Mol.Biol., 396, 2010
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8QBB
 | | Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/-sterol (DOPC, DOPE, DOPS, PI(4,5)P2 50:20:20:10) | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Sphingolipid long chain base-responsive protein PIL1 | | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | | 登録日 | 2023-08-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Nature, 632, 2024
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8QZP
 | | Structure of the non-mitochondrial citrate synthase from Ananas comosus | | 分子名称: | Citrate synthase | | 著者 | Lo, Y.K, Bohn, S, Sendker, F.L, Schuller, J.M, Hochberg, G. | | 登録日 | 2023-10-28 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | | 主引用文献 | Frequent transitions in self-assembly across the evolution of a central metabolic enzyme.
Biorxiv, 2024
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8QBD
 | | Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10) | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Sphingolipid long chain base-responsive protein PIL1 | | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | | 登録日 | 2023-08-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Nature, 632, 2024
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8QBG
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8QBE
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7B8W
 | | Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470 | | 分子名称: | 1,2-ETHANEDIOL, 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide, LIM domain kinase 1 | | 著者 | Lee, H, Yosaatmadja, Y, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Elkins, J.M. | | 登録日 | 2020-12-13 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470
To Be Published
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8QB9
 | | Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture -PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol 30:20:20:30) | | 分子名称: | Sphingolipid long chain base-responsive protein PIL1 | | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | | 登録日 | 2023-08-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Nature, 632, 2024
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7SJJ
 | | Crystal structure of photoactive yellow protein (PYP); F96oCNF construct | | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | | 著者 | Weaver, J.B, Kirsh, J.M, Boxer, S.G. | | 登録日 | 2021-10-17 | | 公開日 | 2022-05-11 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Nitrile Infrared Intensities Characterize Electric Fields and Hydrogen Bonding in Protic, Aprotic, and Protein Environments.
J.Am.Chem.Soc., 144, 2022
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3L4K
 | | Topoisomerase II-DNA cleavage complex, metal-bound | | 分子名称: | 3'-THIO-THYMIDINE-5'-PHOSPHATE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... | | 著者 | Schmidt, B.H, Burgin, A.B, Deweese, J.E, Osheroff, N, Berger, J.M. | | 登録日 | 2009-12-20 | | 公開日 | 2010-05-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Nature, 465, 2010
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3KRY
 | | Crystal structure of MMP-13 in complex with SC-78080 | | 分子名称: | 1-(2-methoxyethyl)-N-oxo-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide, CALCIUM ION, Collagenase 3, ... | | 著者 | Kiefer, J.R, Williams, J.M, Becker, D.P. | | 登録日 | 2009-11-19 | | 公開日 | 2010-10-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease
J.Med.Chem., 53, 2010
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7S6H
 | | Human PARP1 deltaV687-E688 bound to NAD+ analog EB-47 and to a DNA double strand break. | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, DNA (5'-D(*CP*GP*AP*CP*G)-3'), ... | | 著者 | Rouleau-Turcotte, E, Pascal, J.M. | | 登録日 | 2021-09-14 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Mol.Cell, 82, 2022
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7S81
 | | Structure of human PARP1 domains (Zn1, Zn3, WGR, HD) bound to a DNA double strand break. | | 分子名称: | DNA (5'-D(*AP*TP*GP*CP*GP*GP*CP*CP*GP*CP*AP*T)-3'), Poly [ADP-ribose] polymerase 1, ZINC ION | | 著者 | Rouleau-Turcotte, E, Pascal, J.M. | | 登録日 | 2021-09-17 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Mol.Cell, 82, 2022
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3L7D
 | | Crystal Structure of Glycogen Phosphorylase DK5 complex | | 分子名称: | 1-(2,3-dideoxy-3-fluoro-beta-D-arabino-hexopyranosyl)-4-[(phenylcarbonyl)amino]pyrimidin-2(1H)-one, Glycogen phosphorylase, muscle form | | 著者 | Tsirkone, V.G, Lamprakis, C, Hayes, J.M, Skamnaki, V, Drakou, C, Zographos, S.E, Leonidas, D.D. | | 登録日 | 2009-12-28 | | 公開日 | 2010-10-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
Bioorg.Med.Chem., 18, 2010
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7S6M
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7S68
 | | Structure of human PARP1 domains (Zn1, Zn3, WGR and HD) bound to a DNA double strand break. | | 分子名称: | DNA (5'-D(*GP*CP*CP*TP*GP*CP*AP*GP*GP*C)-3'), Fusion of PARP1 zinc fingers 1 and 3 (Zn1, Zn3), ... | | 著者 | Rouleau-Turcotte, E, Pascal, J.M. | | 登録日 | 2021-09-13 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Mol.Cell, 82, 2022
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3L6D
 | | Crystal structure of putative oxidoreductase from Pseudomonas putida KT2440 | | 分子名称: | Putative oxidoreductase | | 著者 | Malashkevich, V.N, Patskovsky, Y, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-12-23 | | 公開日 | 2010-01-12 | | 最終更新日 | 2021-02-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of putative oxidoreductase from Pseudomonas putida KT2440
To be Published
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7RZI
 | | Insulin Degrading Enzyme pC/pC | | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | | 登録日 | 2021-08-27 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7RZH
 | | Insulin Degrading Enzyme O/O | | 分子名称: | Cysteine-free Insulin-degrading enzyme | | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | | 登録日 | 2021-08-27 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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