7S68

Structure of human PARP1 domains (Zn1, Zn3, WGR and HD) bound to a DNA double strand break.

Summary for 7S68

• Entry DOI: 10.2210/pdb7s68/pdb
• Related: 7S6H 7S6M 7S81
• Descriptor: DNA (5'-D(*GP*CP*CP*TP*GP*CP*AP*GP*GP*C)-3'), Poly [ADP-ribose] polymerase 1, Fusion of PARP1 zinc fingers 1 and 3 (Zn1, Zn3), ... (4 entities in total)
• Functional Keywords: parp, adp-ribose transferase, dna break detection, zinc finger, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 67299.32

Authors

Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2021-09-13, release date: 2022-06-29, Last modification date: 2023-10-18)

• Primary citation: Rouleau-Turcotte, E.,Krastev, D.B.,Pettitt, S.J.,Lord, C.J.,Pascal, J.M.; Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.; Mol.Cell, 82:2939-2951.e5, 2022; PubMed: 35793673; DOI: 10.1016/j.molcel.2022.06.011

Experimental method

X-RAY DIFFRACTION (3.3 Å)