7S68
Structure of human PARP1 domains (Zn1, Zn3, WGR and HD) bound to a DNA double strand break.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | M, N | DNA (5'-D(*GP*CP*CP*TP*GP*CP*AP*GP*GP*C)-3') | polymer | 10 | 3046.0 | 2 | DNA molecule | ||
2 | B | Poly [ADP-ribose] polymerase 1 | polymer | 266 | 29813.7 | 1 | UniProt (P09874) Pfam (PF05406) Pfam (PF02877) In PDB | Homo sapiens (Human) | PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,DNA ADP-ribosyltransferase PARP1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1,Protein poly-ADP-ribosyltransferase PARP1 |
3 | A | Fusion of PARP1 zinc fingers 1 and 3 (Zn1, Zn3) | polymer | 276 | 31262.8 | 1 | UniProt (P09874) Pfam (PF00645) Pfam (PF21728) Pfam (PF08063) In PDB | Homo sapiens (Human) | Poly [ADP-ribose] polymerase 1,PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,DNA ADP-ribosyltransferase PARP1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1,Protein poly-ADP-ribosyltransferase PARP1 |
4 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
B: 527 - 786 (UniProt: P09874)
A: 1 - 205 (UniProt: P09874)
A: 206 - 366 (UniProt: P09874)
PDB | External Database | Details |
---|---|---|
Met 507 | - | initiating methionine |
Gly 508 | - | expression tag |
Ser 509 | - | expression tag |
Ser 510 | - | expression tag |
His 511 | - | expression tag |
His 512 | - | expression tag |
His 513 | - | expression tag |
His 514 | - | expression tag |
His 515 | - | expression tag |
His 516 | - | expression tag |
Ser 517 | - | expression tag |
Ser 518 | - | expression tag |
Gly 519 | - | expression tag |
Leu 520 | - | expression tag |
Val 521 | - | expression tag |
Pro 522 | - | expression tag |
Arg 523 | - | expression tag |
Gly 524 | - | expression tag |
Ser 525 | - | expression tag |
His 526 | - | expression tag |
- | Ser 663 | deletion |
- | Lys 664 | deletion |
- | Leu 665 | deletion |
- | Pro 666 | deletion |
- | Lys 667 | deletion |
- | Pro 668 | deletion |
- | Val 669 | deletion |
- | Gln 670 | deletion |
- | Asp 671 | deletion |
- | Leu 672 | deletion |
- | Ile 673 | deletion |
- | Lys 674 | deletion |
- | Met 675 | deletion |
- | Ile 676 | deletion |
Ala 762 | Val 762 | variant |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 67168.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 67299.3 |