3KRY

Crystal structure of MMP-13 in complex with SC-78080

Summary for 3KRY

Entry DOI	10.2210/pdb3kry/pdb
Related	1HFC 966C
Descriptor	Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	collagenase, collagenase-3, mmp-13, collagen degradation, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, protease, secreted
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains	4
Total formula weight	76952.67
Authors	Kiefer, J.R.,Williams, J.M.,Becker, D.P. (deposition date: 2009-11-19, release date: 2010-10-06, Last modification date: 2024-02-21)
Primary citation	Becker, D.P.,Barta, T.E.,Bedell, L.J.,Boehm, T.L.,Bond, B.R.,Carroll, J.,Carron, C.P.,Decrescenzo, G.A.,Easton, A.M.,Freskos, J.N.,Funckes-Shippy, C.L.,Heron, M.,Hockerman, S.,Howard, C.P.,Kiefer, J.R.,Li, M.H.,Mathis, K.J.,McDonald, J.J.,Mehta, P.P.,Munie, G.E.,Sunyer, T.,Swearingen, C.A.,Villamil, C.I.,Welsch, D.,Williams, J.M.,Yu, Y.,Yao, J. Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease J.Med.Chem., 53:6653-6680, 2010 Cited by PubMed: 20726512 DOI: 10.1021/jm100669j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation