Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0031012 | cellular_component | extracellular matrix |
D | 0004222 | molecular_function | metalloendopeptidase activity |
D | 0006508 | biological_process | proteolysis |
D | 0008237 | molecular_function | metallopeptidase activity |
D | 0008270 | molecular_function | zinc ion binding |
D | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1998 |
Chain | Residue |
A | HIS172 |
A | ASP174 |
A | HIS187 |
A | HIS200 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1999 |
Chain | Residue |
A | HIS222 |
A | HIS226 |
A | HIS232 |
A | 3KR1800 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 1996 |
Chain | Residue |
A | ASP162 |
A | ASN194 |
A | GLY196 |
A | ASP198 |
A | HOH303 |
A | HOH14 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 1997 |
Chain | Residue |
A | ASP179 |
A | GLY180 |
A | SER182 |
A | LEU184 |
A | ASP202 |
A | GLU205 |
site_id | AC5 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 3KR A 1800 |
Chain | Residue |
A | HOH33 |
A | LEU184 |
A | LEU185 |
A | ALA186 |
A | VAL219 |
A | HIS222 |
A | GLU223 |
A | HIS226 |
A | HIS232 |
A | ALA238 |
A | LEU239 |
A | PHE241 |
A | PRO242 |
A | ILE243 |
A | TYR244 |
A | THR245 |
A | HOH299 |
A | HOH328 |
A | ZN1999 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 2998 |
Chain | Residue |
B | HIS172 |
B | ASP174 |
B | HIS187 |
B | HIS200 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 2999 |
Chain | Residue |
B | HIS222 |
B | HIS226 |
B | HIS232 |
B | 3KR2800 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 2996 |
Chain | Residue |
B | HOH96 |
B | ASP162 |
B | ASN194 |
B | GLY196 |
B | ASP198 |
B | HOH295 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 2997 |
Chain | Residue |
B | ASP179 |
B | GLY180 |
B | SER182 |
B | LEU184 |
B | ASP202 |
B | GLU205 |
site_id | BC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 3KR B 2800 |
Chain | Residue |
B | LEU184 |
B | LEU185 |
B | ALA186 |
B | LEU218 |
B | VAL219 |
B | HIS222 |
B | GLU223 |
B | HIS226 |
B | HIS232 |
B | ALA238 |
B | LEU239 |
B | PHE241 |
B | PRO242 |
B | ILE243 |
B | TYR244 |
B | THR245 |
B | THR247 |
B | HOH302 |
B | HOH419 |
B | HOH519 |
B | ZN2999 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 3998 |
Chain | Residue |
C | HIS172 |
C | ASP174 |
C | HIS187 |
C | HIS200 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 3999 |
Chain | Residue |
C | HIS222 |
C | HIS226 |
C | HIS232 |
C | 3KR3800 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 3996 |
Chain | Residue |
C | ASP162 |
C | ASN194 |
C | GLY196 |
C | ASP198 |
C | HOH283 |
C | HOH438 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 3997 |
Chain | Residue |
C | GLU205 |
C | ASP179 |
C | GLY180 |
C | SER182 |
C | LEU184 |
C | ASP202 |
site_id | BC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE 3KR C 3800 |
Chain | Residue |
C | GLY183 |
C | LEU184 |
C | LEU185 |
C | ALA186 |
C | LEU218 |
C | VAL219 |
C | HIS222 |
C | GLU223 |
C | HIS226 |
C | HIS232 |
C | LEU239 |
C | PHE241 |
C | PRO242 |
C | ILE243 |
C | TYR244 |
C | THR245 |
C | THR247 |
C | HOH368 |
C | HOH483 |
C | ZN3999 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 4998 |
Chain | Residue |
D | HIS172 |
D | ASP174 |
D | HIS187 |
D | HIS200 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 4999 |
Chain | Residue |
D | HIS222 |
D | HIS226 |
D | HIS232 |
D | 3KR4800 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA D 4996 |
Chain | Residue |
D | ASP162 |
D | ASN194 |
D | GLY196 |
D | ASP198 |
D | HOH286 |
D | HOH305 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA D 4997 |
Chain | Residue |
D | ASP179 |
D | GLY180 |
D | SER182 |
D | LEU184 |
D | ASP202 |
D | GLU205 |
site_id | CC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 3KR D 4800 |
Chain | Residue |
D | GLY183 |
D | LEU184 |
D | LEU185 |
D | ALA186 |
D | LEU218 |
D | VAL219 |
D | HIS222 |
D | GLU223 |
D | HIS226 |
D | HIS232 |
D | LEU239 |
D | PHE241 |
D | PRO242 |
D | ILE243 |
D | TYR244 |
D | THR245 |
D | THR247 |
D | ZN4999 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
Chain | Residue | Details |
A | VAL219-LEU228 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU223 | |
B | GLU223 | |
C | GLU223 | |
D | GLU223 | |
site_id | SWS_FT_FI2 |
Number of Residues | 48 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
Chain | Residue | Details |
A | ASP128 | |
A | ASP202 | |
A | ASP203 | |
A | GLU205 | |
B | ASP128 | |
B | ASP162 | |
B | ASP179 | |
B | GLY180 | |
B | SER182 | |
B | LEU184 | |
B | ASN194 | |
A | ASP162 | |
B | GLY196 | |
B | ASP198 | |
B | ASP202 | |
B | ASP203 | |
B | GLU205 | |
C | ASP128 | |
C | ASP162 | |
C | ASP179 | |
C | GLY180 | |
C | SER182 | |
A | ASP179 | |
C | LEU184 | |
C | ASN194 | |
C | GLY196 | |
C | ASP198 | |
C | ASP202 | |
C | ASP203 | |
C | GLU205 | |
D | ASP128 | |
D | ASP162 | |
D | ASP179 | |
A | GLY180 | |
D | GLY180 | |
D | SER182 | |
D | LEU184 | |
D | ASN194 | |
D | GLY196 | |
D | ASP198 | |
D | ASP202 | |
D | ASP203 | |
D | GLU205 | |
A | SER182 | |
A | LEU184 | |
A | ASN194 | |
A | GLY196 | |
A | ASP198 | |
site_id | SWS_FT_FI3 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
Chain | Residue | Details |
A | HIS172 | |
B | ASP174 | |
B | HIS187 | |
B | HIS200 | |
B | HIS222 | |
B | HIS226 | |
B | HIS232 | |
B | MET240 | |
C | HIS172 | |
C | ASP174 | |
C | HIS187 | |
A | ASP174 | |
C | HIS200 | |
C | HIS222 | |
C | HIS226 | |
C | HIS232 | |
C | MET240 | |
D | HIS172 | |
D | ASP174 | |
D | HIS187 | |
D | HIS200 | |
D | HIS222 | |
A | HIS187 | |
D | HIS226 | |
D | HIS232 | |
D | MET240 | |
A | HIS200 | |
A | HIS222 | |
A | HIS226 | |
A | HIS232 | |
A | MET240 | |
B | HIS172 | |
Chain | Residue | Details |
A | ASN117 | |
B | ASN117 | |
C | ASN117 | |
D | ASN117 | |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN152 | |
B | ASN152 | |
C | ASN152 | |
D | ASN152 | |