7S81

Structure of human PARP1 domains (Zn1, Zn3, WGR, HD) bound to a DNA double strand break.

Summary for 7S81

• Entry DOI: 10.2210/pdb7s81/pdb
• Related: 7S68 7S6H 7S6M
• Descriptor: DNA (5'-D(*AP*TP*GP*CP*GP*GP*CP*CP*GP*CP*AP*T)-3'), Poly [ADP-ribose] polymerase 1, ZINC ION, ... (6 entities in total)
• Functional Keywords: parp, adp-ribose transferase, dna break detection, zinc finger, dna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 260411.98

Authors

Rouleau-Turcotte, E.,Pascal, J.M. (deposition date: 2021-09-17, release date: 2022-06-29, Last modification date: 2023-10-18)

• Primary citation: Rouleau-Turcotte, E.,Krastev, D.B.,Pettitt, S.J.,Lord, C.J.,Pascal, J.M.; Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.; Mol.Cell, 82:2939-2951.e5, 2022; PubMed: 35793673; DOI: 10.1016/j.molcel.2022.06.011

Experimental method

X-RAY DIFFRACTION (3.6 Å)