7S81
Structure of human PARP1 domains (Zn1, Zn3, WGR, HD) bound to a DNA double strand break.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
| F | 0003677 | molecular_function | DNA binding |
| F | 0008270 | molecular_function | zinc ion binding |
| G | 0008270 | molecular_function | zinc ion binding |
| H | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
| I | 0003677 | molecular_function | DNA binding |
| I | 0008270 | molecular_function | zinc ion binding |
| J | 0008270 | molecular_function | zinc ion binding |
| K | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
| N | 0003677 | molecular_function | DNA binding |
| N | 0008270 | molecular_function | zinc ion binding |
| O | 0008270 | molecular_function | zinc ion binding |
| P | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00347 |
| Number of Residues | 36 |
| Details | ZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKkCsesIpKdslRmaimvqspmfdgkvph..WYHfsC |
| Chain | Residue | Details |
| N | CYS21-CYS56 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 384 |
| Details | Domain: {"description":"WGR","evidences":[{"source":"PROSITE-ProRule","id":"PRU01321","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine; by PRKDC","evidences":[{"source":"PubMed","id":"35460603","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 168 |
| Details | Zinc finger: {"description":"PARP-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00264","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00264","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21233213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22582261","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ODA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 168 |
| Details | Region: {"description":"Zinc ribbon","evidences":[{"source":"PROSITE-ProRule","id":"PRU01351","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01351","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18055453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22582261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 268 |
| Details | Domain: {"description":"PADR1 zinc-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01351","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
