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PDB: 2408 results

8UAP
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Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441
Descriptor: (3Z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1H-pyrrol-2-yl]methylidene}-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5
Authors:Chen, Y, Tesmer, J.J.G.
Deposit date:2023-09-21
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.
Eur.J.Med.Chem., 264, 2023
8UAQ
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Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL018-21
Descriptor: (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5
Authors:Chen, Y, Tesmer, J.J.G.
Deposit date:2023-09-21
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes.
Eur.J.Med.Chem., 264, 2023
4ECE
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BU of 4ece by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine
Descriptor: GUANINE, Purine nucleoside phosphorylase
Authors:Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-26
Release date:2013-02-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
2GDS
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BU of 2gds by Molmil
Interrupting the Hydrogen Bonding Network at the Active Site of Human Manganese Superoxide Dismutase
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Perry, J.J.
Deposit date:2006-03-16
Release date:2006-03-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interrupting the Hydrogen Bond Network at the Active Site of Human Manganese Superoxide Dismutase
J.Biol.Chem., 274, 1999
1ZO8
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BU of 1zo8 by Molmil
X-ray Structure of the haloalcohol dehalogenase HheC of Agrobacterium radiobacter AD1 in complex with (S)-para-nitrostyrene oxide, with a water molecule in the halide-binding site
Descriptor: (S)-PARA-NITROSTYRENE OXIDE, halohydrin dehalogenase
Authors:de Jong, R.M, Tiesinga, J.J.W, Tang, L, Villa, A, Janssen, D.B, Dijkstra, B.W.
Deposit date:2005-05-12
Release date:2005-10-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Enantioselectivity of an Epoxide Ring Opening Reaction Catalyzed by Halo Alcohol Dehalogenase HheC.
J.Am.Chem.Soc., 127, 2005
2GDF
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BU of 2gdf by Molmil
Crystal structure of Dioclea violacea seed lectin
Descriptor: CALCIUM ION, MANGANESE (II) ION, lectin
Authors:Gallego del Sol, F, Chornet, J.J.C, Cavada, B.S.
Deposit date:2006-03-16
Release date:2006-09-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Dioclea violacea seed lectin
To be published
1EFV
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BU of 1efv by Molmil
THREE-DIMENSIONAL STRUCTURE OF HUMAN ELECTRON TRANSFER FLAVOPROTEIN TO 2.1 A RESOLUTION
Descriptor: ADENOSINE MONOPHOSPHATE, ELECTRON TRANSFER FLAVOPROTEIN, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Roberts, D.L, Frerman, F.E, Kim, J.J.P.
Deposit date:1996-10-16
Release date:1997-12-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution.
Proc.Natl.Acad.Sci.USA, 93, 1996
1YY9
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BU of 1yy9 by Molmil
Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab Heavy chain, ...
Authors:Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M.
Deposit date:2005-02-24
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Cancer Cell, 7, 2005
7K14
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BU of 7k14 by Molmil
Ternary soak structure of alkanesulfonate monooxygenase MsuD from Pseudomonas fluorescens with FMN and methanesulfonate
Descriptor: Alkanesulfonate monooxygenase, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Liew, J.J.M, Dowling, D.P, El Saudi, I.M.
Deposit date:2020-09-07
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer.
J.Biol.Chem., 297, 2021
7JYB
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BU of 7jyb by Molmil
Binary soak structure of alkanesulfonate monooxygenase MsuD from Pseudomonas fluorescens with FMN
Descriptor: Alkanesulfonate monooxygenase, FLAVIN MONONUCLEOTIDE, PHOSPHATE ION, ...
Authors:Liew, J.J.M, Dowling, D.P, El Saudi, I.M.
Deposit date:2020-08-30
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer.
J.Biol.Chem., 297, 2021
7JW9
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BU of 7jw9 by Molmil
Ternary cocrystal structure of alkanesulfonate monooxygenase MsuD from Pseudomonas fluorescens
Descriptor: Alkanesulfonate monooxygenase, FLAVIN MONONUCLEOTIDE, SODIUM ION, ...
Authors:Liew, J.J.M, Dowling, D.P.
Deposit date:2020-08-25
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer.
J.Biol.Chem., 297, 2021
7JV3
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BU of 7jv3 by Molmil
Crystal structure of alkanesulfonate monooxygenase MsuD from Pseudomonas fluorescens
Descriptor: Alkanesulfonate monooxygenase
Authors:Liew, J.J.M, Dowling, D.P.
Deposit date:2020-08-20
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer.
J.Biol.Chem., 297, 2021
7K64
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BU of 7k64 by Molmil
Binary titrated soak structure of alkanesulfonate monooxygenase MsuD from Pseudomonas fluorescens with FMN
Descriptor: Alkanesulfonate monooxygenase, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Liew, J.J.M, Dowling, D.P.
Deposit date:2020-09-18
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer.
J.Biol.Chem., 297, 2021
4EB8
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BU of 4eb8 by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
Descriptor: 1,2-ETHANEDIOL, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, ...
Authors:Ho, M.C, Haapalainen, A.M, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-23
Release date:2013-02-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
1YY8
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BU of 1yy8 by Molmil
Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225
Descriptor: Cetuximab Fab Heavy chain, Cetuximab Fab Light chain
Authors:Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M.
Deposit date:2005-02-24
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Cancer Cell, 7, 2005
1CJK
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BU of 1cjk by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ...
Authors:Tesmer, J.J.G, Sprang, S.R.
Deposit date:1999-04-16
Release date:1999-08-31
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1ZAE
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BU of 1zae by Molmil
Solution structure of the functional domain of phi29 replication organizer p16.7c
Descriptor: Early protein GP16.7
Authors:Asensio, J.L, Albert, A, Munoz-Espin, D, Gonzalez, C, Hermoso, J, Villar, L, Jimenez-Barbero, J, Salas, M, Meijer, W.J.J.
Deposit date:2005-04-06
Release date:2005-04-19
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure of the functional domain of phi29 replication organizer: insights into oligomerization and dna binding
J.Biol.Chem., 280, 2005
4EAR
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BU of 4ear by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
Descriptor: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-22
Release date:2013-02-06
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
1ZCA
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BU of 1zca by Molmil
Crystal structure of G alpha 12 in complex with GDP, Mg2+ and AlF4-
Descriptor: G alpha i/12, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2005-04-11
Release date:2005-11-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
1DHG
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BU of 1dhg by Molmil
HG-SUBSTITUTED DESULFOREDOXIN
Descriptor: MERCURY (II) ION, PROTEIN (DESULFOREDOXIN)
Authors:Archer, M, Carvalho, A.L, Teixeira, S, Moura, I, Moura, J.J.G, Rusnak, F, Romao, M.J.
Deposit date:1999-03-22
Release date:1999-07-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural studies by X-ray diffraction on metal substituted desulforedoxin, a rubredoxin-type protein.
Protein Sci., 8, 1999
1E08
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BU of 1e08 by Molmil
Structural model of the [Fe]-Hydrogenase/cytochrome c553 complex combining NMR and soft-docking
Descriptor: 1,3-PROPANEDITHIOL, CARBON MONOXIDE, CYANIDE ION, ...
Authors:Morelli, X, Czjzek, M, Hatchikian, C.E, Bornet, O, Fontecilla-Camps, J.C, Palma, N.P, Moura, J.J.G, Guerlesquin, F.
Deposit date:2000-03-13
Release date:2000-08-25
Last modified:2019-11-27
Method:SOLUTION NMR, THEORETICAL MODEL
Cite:Structural Model of the Fe-Hydrogenase/Cytochrome C553 Complex Combining Transverse Relaxation-Optimized Spectroscopy Experiments and Soft Docking Calculations.
J.Biol.Chem., 275, 2000
7MTB
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BU of 7mtb by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6
Descriptor: Fab6 heavy chain, Fab6 light chain, RETINAL, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
7MT8
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BU of 7mt8 by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin
Descriptor: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
7MTA
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BU of 7mta by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1
Descriptor: Fab1 Heavy chain, Fab1 Light chain, RETINAL, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
7MT9
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Rhodopsin kinase (GRK1) in complex with rhodopsin
Descriptor: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021

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