6B4M
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![BU of 6b4m by Molmil](/molmil-images/mine/6b4m) | Structural characterization of a novel monotreme-specific protein from the milk of the platypus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, IODIDE ION, ... | 著者 | Peat, T.S, Newman, J, Sharp, J.A, Kumar, A, Nicholas, K.R, Adams, T.E. | 登録日 | 2017-09-27 | 公開日 | 2018-01-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus. Acta Crystallogr F Struct Biol Commun, 74, 2018
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2A8M
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6UWX
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2ADW
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6B8T
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![BU of 6b8t by Molmil](/molmil-images/mine/6b8t) | Multiconformer model of apo WT PTP1B with glycerol at 240 K | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. | 登録日 | 2017-10-09 | 公開日 | 2018-06-20 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
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2AB2
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![BU of 2ab2 by Molmil](/molmil-images/mine/2ab2) | Mineralocorticoid Receptor Double Mutant with Bound Spironolactone | 分子名称: | Mineralocorticoid receptor, SPIRONOLACTONE, SULFATE ION | 著者 | Bledsoe, R.K, Madauss, K.P, Holt, J.A, Apolito, C.J, Lambert, M.H, Pearce, K.H, Stanley, T.B, Stewart, E.L, Trump, R.P, Willson, T.M, Williams, S.P. | 登録日 | 2005-07-14 | 公開日 | 2005-07-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor J.Biol.Chem., 280, 2005
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2AF1
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6BAI
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![BU of 6bai by Molmil](/molmil-images/mine/6bai) | Multiconformer model of apo K197C PTP1B at 100 K | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. | 登録日 | 2017-10-12 | 公開日 | 2018-06-20 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
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5C3G
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![BU of 5c3g by Molmil](/molmil-images/mine/5c3g) | Crystal structure of Bcl-xl bound to BIM-MM | 分子名称: | Bcl-2-like protein 1,Bcl-2-like protein 1, Bcl-2-like protein 11 | 著者 | Miles, J.A, Yeo, D.J, Rowell, P, Rodriguez-Marin, S, Pask, C.M, Warriner, S.L, Edwards, T.A, Wilson, A.J. | 登録日 | 2015-06-17 | 公開日 | 2016-04-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Hydrocarbon constrained peptides - understanding preorganisation and binding affinity. Chem Sci, 7, 2016
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6B8X
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![BU of 6b8x by Molmil](/molmil-images/mine/6b8x) | Multiconformer model of apo WT PTP1B with glycerol at 278 K | 分子名称: | GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. | 登録日 | 2017-10-09 | 公開日 | 2018-06-20 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
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2A8L
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6UPU
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6UPS
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2AZ2
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![BU of 2az2 by Molmil](/molmil-images/mine/2az2) | Flock House virus B2-dsRNA Complex (P4122) | 分子名称: | 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3', B2 protein | 著者 | Chao, J.A, Lee, J.H, Chapados, B.R, Debler, E.W, Schneemann, A, Williamson, J.R. | 登録日 | 2005-09-09 | 公開日 | 2005-10-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Dual modes of RNA-silencing suppression by Flock House virus protein B2. Nat.Struct.Mol.Biol., 12, 2005
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6B3K
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![BU of 6b3k by Molmil](/molmil-images/mine/6b3k) | Crystal structure of mutant Spinach RNA aptamer in complex with Fab BL3-6 | 分子名称: | Heavy chain of Fab BL3-6, Light chain of Fab BL3-6, MAGNESIUM ION, ... | 著者 | DasGupta, S, Koirala, D, Shelke, S.A, Piccirilli, J.A. | 登録日 | 2017-09-22 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography. Nucleic Acids Res., 46, 2018
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2AWJ
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![BU of 2awj by Molmil](/molmil-images/mine/2awj) | GFP R96M pre-cyclized intermediate in chromophore formation | 分子名称: | MAGNESIUM ION, green-fluorescent protein | 著者 | Wood, T.I, Barondeau, D.P, Hitomi, C, Kassmann, C.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2005-09-01 | 公開日 | 2006-04-18 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis. Biochemistry, 44, 2005
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6B8E
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![BU of 6b8e by Molmil](/molmil-images/mine/6b8e) | Multiconformer model of apo WT PTP1B with glycerol at 180 K | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. | 登録日 | 2017-10-06 | 公開日 | 2018-06-20 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
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5CI5
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![BU of 5ci5 by Molmil](/molmil-images/mine/5ci5) | Crystal Structure of an ABC transporter Solute Binding Protein from Thermotoga Lettingae TMO (Tlet_1705, TARGET EFI-510544) bound with alpha-D-Tagatose | 分子名称: | 1,2-ETHANEDIOL, Extracellular solute-binding protein family 1, PENTAETHYLENE GLYCOL, ... | 著者 | Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Koss, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2015-07-11 | 公開日 | 2015-07-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Crystal Structure of an ABC transporter Solute Binding Protein from Thermotoga Lettingae TMO (Tlet_1705, TARGET EFI-510544) bound with alpha-D-Tagatose To be published
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2B60
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![BU of 2b60 by Molmil](/molmil-images/mine/2b60) | Structure of HIV-1 protease mutant bound to Ritonavir | 分子名称: | GLYCEROL, Gag-Pol polyprotein, RITONAVIR | 著者 | Clemente, J.C, Stow, L.R, Janka, L.K, Jeung, J.A, Desai, K.A, Govindasamy, L, Agbandje-McKenna, M, McKenna, R, Goodenow, M.M, Dunn, B.M. | 登録日 | 2005-09-29 | 公開日 | 2006-11-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | In vivo, kinetic, and structural analysis of the development of ritonavir resistance To be Published
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6B7H
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![BU of 6b7h by Molmil](/molmil-images/mine/6b7h) | Structure of mGluR3 with an agonist | 分子名称: | (1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Monn, J.A, Clawson, D.K. | 登録日 | 2017-10-04 | 公開日 | 2018-04-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist. J. Med. Chem., 61, 2018
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2AWL
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![BU of 2awl by Molmil](/molmil-images/mine/2awl) | Mature R96K GFP mutant | 分子名称: | MAGNESIUM ION, green fluorescent protein | 著者 | Wood, T.I, Barondeau, D.P, Hitomi, C, Kassmann, C.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2005-09-01 | 公開日 | 2006-04-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis. Biochemistry, 44, 2005
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5C7U
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![BU of 5c7u by Molmil](/molmil-images/mine/5c7u) | 5'-monophosphate wt Guanine Riboswitch bound to hypoxanthine. | 分子名称: | 5'-monophosphate wt guanine riboswitch, COBALT HEXAMMINE(III), HYPOXANTHINE | 著者 | Hernandez, A.R, Shao, Y, Hoshika, S, Yang, Z, Shelke, S.A, Herrou, J, Kim, H.-J, Kim, M.-J, Piccirilli, J.A, Benner, S.A. | 登録日 | 2015-06-24 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair. Angew.Chem.Int.Ed.Engl., 54, 2015
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2AZ0
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![BU of 2az0 by Molmil](/molmil-images/mine/2az0) | Flock House virus B2-dsRNA Complex (P212121) | 分子名称: | 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3', B2 protein | 著者 | Chao, J.A, Lee, J.H, Chapados, B.R, Debler, E.W, Schneemann, A, Williamson, J.R. | 登録日 | 2005-09-09 | 公開日 | 2005-10-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Dual modes of RNA-silencing suppression by Flock House virus protein B2. Nat.Struct.Mol.Biol., 12, 2005
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6UVM
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![BU of 6uvm by Molmil](/molmil-images/mine/6uvm) | Cocrystal of BRD4(D1) with a methyl carbamate thiazepane inhibitor | 分子名称: | 1,2-ETHANEDIOL, 1-[(7S)-7-(thiophen-2-yl)-6,7-dihydro-1,4-thiazepin-4(5H)-yl]ethan-1-one, Bromodomain-containing protein 4 | 著者 | Johnson, J.A, Pomerantz, W.C.K. | 登録日 | 2019-11-03 | 公開日 | 2020-01-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. Acs Med.Chem.Lett., 10, 2019
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6B95
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![BU of 6b95 by Molmil](/molmil-images/mine/6b95) | Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-(2',4'-difluoro-4-hydroxy[1,1'-biphenyl]-3-yl)-2-sulfanylacetamide, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. | 登録日 | 2017-10-10 | 公開日 | 2018-06-20 | 最終更新日 | 2022-03-23 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
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