6B8X

Multiconformer model of apo WT PTP1B with glycerol at 278 K

Summary for 6B8X

Entry DOI	10.2210/pdb6b8x/pdb
Related	6B8E 6B8T
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, GLYCEROL (3 entities in total)
Functional Keywords	protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multitemperature, multiconformer, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37713.94
Authors	Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,von Delft, F.,Wells, J.A.,Fraser, J.S. (deposition date: 2017-10-09, release date: 2018-06-20, Last modification date: 2022-03-23)
Primary citation	Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,Pearce, N.M.,von Delft, F.,Wells, J.A.,Fraser, J.S. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7:-, 2018 Cited by PubMed: 29877794 DOI: 10.7554/eLife.36307 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation