6UWX

Cocrystal of BRD4(D1) with a ethyl carbamate thiazepane inhibitor

Summary for 6UWX

Entry DOI	10.2210/pdb6uwx/pdb
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, ethyl (7S)-7-(thiophen-2-yl)-1,4-thiazepane-4-carboxylate, ... (4 entities in total)
Functional Keywords	brd4(d1), inhibitor, gene regulation-inhibitor complex, gene regulation/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15432.85
Authors	Johnson, J.A.,Pomerantz, W.C.K. (deposition date: 2019-11-05, release date: 2020-01-01, Last modification date: 2023-10-11)
Primary citation	Johnson, J.A.,Nicolaou, C.A.,Kirberger, S.E.,Pandey, A.K.,Hu, H.,Pomerantz, W.C.K. Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. Acs Med.Chem.Lett., 10:1648-1654, 2019 Cited by PubMed: 31857841 DOI: 10.1021/acsmedchemlett.9b00414 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.307 Å)

Structure validation