4F6S
 
 | | Crystal structure of human CDK8/CYCC in complex with compound 7 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea) | | Descriptor: | 1,2-ETHANEDIOL, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, Cyclin-C, ... | | Authors: | Schneider, E.V, Boettcher, J, Huber, R, Maskos, K. | | Deposit date: | 2012-05-15 | | Release date: | 2013-05-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-kinetic relationship study of CDK8/CycC specific compounds.
Proc.Natl.Acad.Sci.USA, 110, 2013
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6R7W
 | | Tannerella forsythia mature mirolysin in complex with a cleaved peptide. | | Descriptor: | CALCIUM ION, CITRIC ACID, ETHANOL, ... | | Authors: | Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X. | | Deposit date: | 2019-03-29 | | Release date: | 2019-11-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases.
Iucrj, 7, 2020
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4FHJ
 | | Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2 | | Descriptor: | 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | Authors: | Shaffer, P.L, Tang, J, Yakowec, P. | | Deposit date: | 2012-06-06 | | Release date: | 2012-07-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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1IB8
 | | SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE | | Descriptor: | CONSERVED PROTEIN SP14.3 | | Authors: | Yu, L, Gunasekera, A.H, Mack, J, Olejniczak, E.T, Chovan, L.E, Ruan, X, Towne, D.L, Lerner, C.G, Fesik, S.W. | | Deposit date: | 2001-03-27 | | Release date: | 2002-03-27 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE
J.Mol.Biol., 311, 2001
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6R3A
 | | BACTERIOPHAGE SPP1 MATURE CAPSID PROTEIN | | Descriptor: | Major capsid protein | | Authors: | Ignatiou, A, El Sadek Fadel, M, Buerger, J, Mielke, T, Topf, M, Tavares, P. | | Deposit date: | 2019-03-19 | | Release date: | 2019-10-23 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural transitions during the scaffolding-driven assembly of a viral capsid.
Nat Commun, 10, 2019
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1I7A
 | | EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2 | | Descriptor: | CITRATE ANION, HOMER 2B, PHE-ALA-PHE, ... | | Authors: | Barzik, M, Carl, U.D, Schubert, W.-D, Wehland, J, Heinz, D.W. | | Deposit date: | 2001-03-08 | | Release date: | 2001-08-22 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | The N-terminal domain of Homer/Vesl is a new class II EVH1 domain.
J.Mol.Biol., 309, 2001
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1HL4
 | | The Structure of Apo Type Human Cu, Zn Superoxide Dismutase | | Descriptor: | SUPEROXIDE DISMUTASE, ZINC ION | | Authors: | Strange, R.W, Antonyuk, S, Hough, M.A, Doucette, P, Rodriguez, J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | | Deposit date: | 2003-03-13 | | Release date: | 2003-05-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | The Structure of Holo and Metal-Deficient Wild-Type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis
J.Mol.Biol., 328, 2003
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1HL5
 | | The Structure of Holo Type Human Cu, Zn Superoxide Dismutase | | Descriptor: | CALCIUM ION, COPPER (II) ION, SUPEROXIDE DISMUTASE, ... | | Authors: | Strange, R.W, Antonyuk, S, Hough, M.A, Doucette, P, Rodriguez, J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | | Deposit date: | 2003-03-13 | | Release date: | 2003-05-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Structure of Holo and Metal-Deficient Wild-Type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis
J.Mol.Biol., 328, 2003
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1HJL
 | | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis protein MobA | | Descriptor: | CITRIC ACID, LITHIUM ION, MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A | | Authors: | Guse, A, Stevenson, C.E.M, Kuper, J, Buchanan, G, Schwarz, G, Mendel, R.R, Lawson, D.M, Palmer, T. | | Deposit date: | 2003-02-27 | | Release date: | 2003-05-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis Protein Moba
J.Biol.Chem., 278, 2003
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1HJJ
 | | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis protein MobA | | Descriptor: | CITRIC ACID, LITHIUM ION, MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A | | Authors: | Guse, A, Stevenson, C.E.M, Kuper, J, Buchanan, G, Schwarz, G, Mendel, R.R, Lawson, D.M, Palmer, T. | | Deposit date: | 2003-02-27 | | Release date: | 2003-05-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis Protein Moba
J.Biol.Chem., 278, 2003
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1IAI
 | | IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX | | Descriptor: | ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A), IDIOTYPIC FAB 730.1.4 (IGG1) OF VIRUS NEUTRALIZING ANTIBODY | | Authors: | Ban, N, Escobar, C, Garcia, R, Hasel, K, Day, J, Greenwood, A, McPherson, A. | | Deposit date: | 1993-12-28 | | Release date: | 1996-03-08 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of an idiotype-anti-idiotype Fab complex.
Proc.Natl.Acad.Sci.USA, 91, 1994
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7CTG
 | | Human Origin Recognition Complex, ORC1-5 State I | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | | Authors: | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | | Deposit date: | 2020-08-18 | | Release date: | 2021-01-06 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Structural insight into the assembly and conformational activation of human origin recognition complex.
Cell Discov, 6, 2020
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7C88
 | | Complex structure of JS003 and PD-L1 | | Descriptor: | JS003 Heavy chain, JS003 Light chain, Programmed cell death 1 ligand 1 | | Authors: | Bi, X, Shi, R, Chai, Y, Qi, J, Yan, J, Tan, S. | | Deposit date: | 2020-05-29 | | Release date: | 2021-04-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.997 Å) | | Cite: | Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy.
Signal Transduct Target Ther, 5, 2020
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7C6P
 | | Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid | | Descriptor: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4 | | Authors: | Li, J, Yu, K, Luo, Y, Zheng, W, Liang, W, Zhu, J. | | Deposit date: | 2020-05-22 | | Release date: | 2021-05-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.
J Enzyme Inhib Med Chem, 36, 2021
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7C2Z
 | | Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone | | Descriptor: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4, FORMIC ACID | | Authors: | Li, J, Zhu, J. | | Deposit date: | 2020-05-10 | | Release date: | 2021-05-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.
J Enzyme Inhib Med Chem, 36, 2021
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7C3V
 | | Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) | | Descriptor: | Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Dai, W, Ni, Y, Xu, G, Liu, Y, Wang, Y, Zhou, J. | | Deposit date: | 2020-05-14 | | Release date: | 2021-05-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.20042944 Å) | | Cite: | Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH)
To Be Published
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7CFP
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7CFQ
 | | Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... | | Authors: | Zhao, J, Zhang, X, Zang, J. | | Deposit date: | 2020-06-27 | | Release date: | 2021-07-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural insights into the recognition of histone H3Q5 serotonylation by WDR5.
Sci Adv, 7, 2021
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7CKK
 | | Structural complex of FTO bound with Dac51 | | Descriptor: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | | Authors: | Yang, C, Gan, J. | | Deposit date: | 2020-07-17 | | Release date: | 2021-07-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Cell Metab., 33, 2021
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7DL2
 | | Cryo-EM structure of human TSC complex | | Descriptor: | Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... | | Authors: | Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y. | | Deposit date: | 2020-11-25 | | Release date: | 2020-12-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural insights into TSC complex assembly and GAP activity on Rheb.
Nat Commun, 12, 2021
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7DPM
 | | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... | | Authors: | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | | Deposit date: | 2020-12-20 | | Release date: | 2021-02-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.304 Å) | | Cite: | Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV.
Mabs, 13, 2021
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7CXY
 | | Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (zinc-bound form) | | Descriptor: | Carbonic anhydrase, ZINC ION | | Authors: | Jin, M.S, Kim, S, Yeon, J, Sung, J, Kim, N.J, Hong, S. | | Deposit date: | 2020-09-02 | | Release date: | 2021-03-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus.
J.Struct.Biol., 213, 2021
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7CXW
 | | Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (C116 flipped form) | | Descriptor: | ACETATE ION, Carbonic anhydrase | | Authors: | Jin, M.S, Kim, S, Yeon, J, Sung, J, Kim, N.J, Hong, S. | | Deposit date: | 2020-09-02 | | Release date: | 2021-03-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus.
J.Struct.Biol., 213, 2021
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7CXX
 | | Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (disulfide-bonded form) | | Descriptor: | ACETATE ION, Carbonic anhydrase, SULFATE ION | | Authors: | Jin, M.S, Kim, S, Yeon, J, Sung, J, Kim, N.J, Hong, S. | | Deposit date: | 2020-09-02 | | Release date: | 2021-03-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus.
J.Struct.Biol., 213, 2021
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6X3X
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, ... | | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | | Deposit date: | 2020-05-21 | | Release date: | 2020-09-09 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
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