4FHJ

Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2

Summary for 4FHJ

• Entry DOI: 10.2210/pdb4fhj/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-amine, ... (4 entities in total)
• Functional Keywords: inhibitor, p110, kinase, transferase, atp-binding, p84, p101, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P48736
• Total number of polymer chains: 1
• Total formula weight: 110515.62

Authors

Shaffer, P.L.,Tang, J.,Yakowec, P. (deposition date: 2012-06-06, release date: 2012-07-18, Last modification date: 2023-09-13)

• Primary citation: Peterson, E.A.,Boezio, A.A.,Andrews, P.S.,Boezio, C.M.,Bush, T.L.,Cheng, A.C.,Choquette, D.,Coats, J.R.,Colletti, A.E.,Copeland, K.W.,Dupont, M.,Graceffa, R.,Grubinska, B.,Kim, J.L.,Lewis, R.T.,Liu, J.,Mullady, E.L.,Potashman, M.H.,Romero, K.,Shaffer, P.L.,Stanton, M.K.,Stellwagen, J.C.,Teffera, Y.,Yi, S.,Cai, T.,La, D.S.; Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.; Bioorg.Med.Chem.Lett., 22:4967-4974, 2012; PubMed: 22765895; DOI: 10.1016/j.bmcl.2012.06.033

Experimental method

X-RAY DIFFRACTION (2.6 Å)