7DL2

Cryo-EM structure of human TSC complex

Summary for 7DL2

• Entry DOI: 10.2210/pdb7dl2/pdb
• EMDB information: 30708 30709 30710 30711
• Descriptor: Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... (4 entities in total)
• Functional Keywords: tsc complex, regulator of cell growth, gtpase-activating protein, elongated arch-shaped fold, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 689396.78

Authors

Yang, H.,Yu, Z.,Chen, X.,Li, J.,Li, N.,Cheng, J.,Gao, N.,Yuan, H.,Ye, D.,Guan, K.,Xu, Y. (deposition date: 2020-11-25, release date: 2020-12-16, Last modification date: 2024-03-27)

• Primary citation: Yang, H.,Yu, Z.,Chen, X.,Li, J.,Li, N.,Cheng, J.,Gao, N.,Yuan, H.X.,Ye, D.,Guan, K.L.,Xu, Y.; Structural insights into TSC complex assembly and GAP activity on Rheb.; Nat Commun, 12:339-339, 2021; PubMed: 33436626; DOI: 10.1038/s41467-020-20522-4

Experimental method

ELECTRON MICROSCOPY (4.4 Å)