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7DL2

Cryo-EM structure of human TSC complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001843biological_processneural tube closure
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006606biological_processprotein import into nucleus
A0006897biological_processendocytosis
A0007507biological_processheart development
A0008104biological_processprotein localization
A0008285biological_processnegative regulation of cell population proliferation
A0009267biological_processcellular response to starvation
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016239biological_processpositive regulation of macroautophagy
A0019902molecular_functionphosphatase binding
A0030100biological_processregulation of endocytosis
A0030178biological_processnegative regulation of Wnt signaling pathway
A0031267molecular_functionsmall GTPase binding
A0032007biological_processnegative regulation of TOR signaling
A0033596cellular_componentTSC1-TSC2 complex
A0042803molecular_functionprotein homodimerization activity
A0043276biological_processanoikis
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0043547biological_processpositive regulation of GTPase activity
A0046626biological_processregulation of insulin receptor signaling pathway
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048471cellular_componentperinuclear region of cytoplasm
A0050918biological_processpositive chemotaxis
A0051056biological_processregulation of small GTPase mediated signal transduction
A0051726biological_processregulation of cell cycle
A0051879molecular_functionHsp90 protein binding
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A1901525biological_processnegative regulation of mitophagy
A1904262biological_processnegative regulation of TORC1 signaling
B0001843biological_processneural tube closure
B0005096molecular_functionGTPase activator activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006606biological_processprotein import into nucleus
B0006897biological_processendocytosis
B0007507biological_processheart development
B0008104biological_processprotein localization
B0008285biological_processnegative regulation of cell population proliferation
B0009267biological_processcellular response to starvation
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0016192biological_processvesicle-mediated transport
B0016239biological_processpositive regulation of macroautophagy
B0019902molecular_functionphosphatase binding
B0030100biological_processregulation of endocytosis
B0030178biological_processnegative regulation of Wnt signaling pathway
B0031267molecular_functionsmall GTPase binding
B0032007biological_processnegative regulation of TOR signaling
B0033596cellular_componentTSC1-TSC2 complex
B0042803molecular_functionprotein homodimerization activity
B0043276biological_processanoikis
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0043547biological_processpositive regulation of GTPase activity
B0046626biological_processregulation of insulin receptor signaling pathway
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0048471cellular_componentperinuclear region of cytoplasm
B0050918biological_processpositive chemotaxis
B0051056biological_processregulation of small GTPase mediated signal transduction
B0051726biological_processregulation of cell cycle
B0051879molecular_functionHsp90 protein binding
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B1901525biological_processnegative regulation of mitophagy
B1904262biological_processnegative regulation of TORC1 signaling
C0000054biological_processribosomal subunit export from nucleus
C0001822biological_processkidney development
C0001843biological_processneural tube closure
C0001952biological_processregulation of cell-matrix adhesion
C0002250biological_processadaptive immune response
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006417biological_processregulation of translation
C0006457biological_processprotein folding
C0006813biological_processpotassium ion transport
C0007160biological_processcell-matrix adhesion
C0007399biological_processnervous system development
C0008283biological_processcell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0008306biological_processassociative learning
C0008344biological_processadult locomotory behavior
C0009267biological_processcellular response to starvation
C0014069cellular_componentpostsynaptic density
C0016020cellular_componentmembrane
C0016242biological_processnegative regulation of macroautophagy
C0017148biological_processnegative regulation of translation
C0021766biological_processhippocampus development
C0021987biological_processcerebral cortex development
C0030027cellular_componentlamellipodium
C0030030biological_processcell projection organization
C0030544molecular_functionHsp70 protein binding
C0032007biological_processnegative regulation of TOR signaling
C0032780biological_processnegative regulation of ATP-dependent activity
C0032868biological_processresponse to insulin
C0032991cellular_componentprotein-containing complex
C0033596cellular_componentTSC1-TSC2 complex
C0036294biological_processcellular response to decreased oxygen levels
C0042030molecular_functionATPase inhibitor activity
C0042552biological_processmyelination
C0043379biological_processmemory T cell differentiation
C0043666biological_processobsolete regulation of phosphoprotein phosphatase activity
C0044183molecular_functionprotein folding chaperone
C0045792biological_processnegative regulation of cell size
C0046323biological_processD-glucose import
C0048471cellular_componentperinuclear region of cytoplasm
C0050808biological_processsynapse organization
C0050821biological_processprotein stabilization
C0051087molecular_functionprotein-folding chaperone binding
C0051492biological_processregulation of stress fiber assembly
C0051726biological_processregulation of cell cycle
C0051879molecular_functionHsp90 protein binding
C0051894biological_processpositive regulation of focal adhesion assembly
C0055007biological_processcardiac muscle cell differentiation
C0090630biological_processactivation of GTPase activity
C0101031cellular_componentprotein folding chaperone complex
C1904262biological_processnegative regulation of TORC1 signaling
D0000054biological_processribosomal subunit export from nucleus
D0001822biological_processkidney development
D0001843biological_processneural tube closure
D0001952biological_processregulation of cell-matrix adhesion
D0002250biological_processadaptive immune response
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006417biological_processregulation of translation
D0006457biological_processprotein folding
D0006813biological_processpotassium ion transport
D0007160biological_processcell-matrix adhesion
D0007399biological_processnervous system development
D0008283biological_processcell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0008306biological_processassociative learning
D0008344biological_processadult locomotory behavior
D0009267biological_processcellular response to starvation
D0014069cellular_componentpostsynaptic density
D0016020cellular_componentmembrane
D0016242biological_processnegative regulation of macroautophagy
D0017148biological_processnegative regulation of translation
D0021766biological_processhippocampus development
D0021987biological_processcerebral cortex development
D0030027cellular_componentlamellipodium
D0030030biological_processcell projection organization
D0030544molecular_functionHsp70 protein binding
D0032007biological_processnegative regulation of TOR signaling
D0032780biological_processnegative regulation of ATP-dependent activity
D0032868biological_processresponse to insulin
D0032991cellular_componentprotein-containing complex
D0033596cellular_componentTSC1-TSC2 complex
D0036294biological_processcellular response to decreased oxygen levels
D0042030molecular_functionATPase inhibitor activity
D0042552biological_processmyelination
D0043379biological_processmemory T cell differentiation
D0043666biological_processobsolete regulation of phosphoprotein phosphatase activity
D0044183molecular_functionprotein folding chaperone
D0045792biological_processnegative regulation of cell size
D0046323biological_processD-glucose import
D0048471cellular_componentperinuclear region of cytoplasm
D0050808biological_processsynapse organization
D0050821biological_processprotein stabilization
D0051087molecular_functionprotein-folding chaperone binding
D0051492biological_processregulation of stress fiber assembly
D0051726biological_processregulation of cell cycle
D0051879molecular_functionHsp90 protein binding
D0051894biological_processpositive regulation of focal adhesion assembly
D0055007biological_processcardiac muscle cell differentiation
D0090630biological_processactivation of GTPase activity
D0101031cellular_componentprotein folding chaperone complex
D1904262biological_processnegative regulation of TORC1 signaling
E0005096molecular_functionGTPase activator activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0009267biological_processcellular response to starvation
E0016020cellular_componentmembrane
E0031267molecular_functionsmall GTPase binding
E0031398biological_processpositive regulation of protein ubiquitination
E0031410cellular_componentcytoplasmic vesicle
E0032007biological_processnegative regulation of TOR signaling
E0033596cellular_componentTSC1-TSC2 complex
E0036064cellular_componentciliary basal body
E0043547biological_processpositive regulation of GTPase activity
E0070848biological_processresponse to growth factor
E0090630biological_processactivation of GTPase activity
E1902018biological_processnegative regulation of cilium assembly
E1904262biological_processnegative regulation of TORC1 signaling
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18308511
ChainResidueDetails
AMET589
ALEU713
BMET589
BLEU713

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
AHIS1019
BHIS1019

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKB/AKT1 => ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:24529379
ChainResidueDetails
AALA1031
BALA1031
CSER511
CSER598

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
AVAL1073
AGLY1567
BVAL1073
BGLY1567

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P49816
ChainResidueDetails
AASP1222
BASP1222
CLYS30

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692
ChainResidueDetails
AASN1224
BASN1224

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATHR1270
BTHR1247

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:14651849
ChainResidueDetails
ASER1386
BSER1363

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER1452
APRO1453
BSER1429
BPRO1430

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR1461
BTYR1438

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
AALA1479
BALA1456

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15963462, ECO:0007744|PubMed:18669648
ChainResidueDetails
ALEU1502
BLEU1502

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1526
BSER1526

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15963462
ChainResidueDetails
ALEU1533
BLEU1533

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15963462, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
AASP1535
BASP1535

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:24529379, ECO:0007744|PubMed:19690332
ChainResidueDetails
AGLY1577
BGLY1577

226707

PDB entries from 2024-10-30

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