7DL2

Cryo-EM structure of human TSC complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001843	biological_process	neural tube closure
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006606	biological_process	protein import into nucleus
A	0006897	biological_process	endocytosis
A	0007507	biological_process	heart development
A	0008104	biological_process	intracellular protein localization
A	0008285	biological_process	negative regulation of cell population proliferation
A	0009267	biological_process	cellular response to starvation
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0016239	biological_process	positive regulation of macroautophagy
A	0016241	biological_process	regulation of macroautophagy
A	0019902	molecular_function	phosphatase binding
A	0030100	biological_process	regulation of endocytosis
A	0030178	biological_process	negative regulation of Wnt signaling pathway
A	0031267	molecular_function	small GTPase binding
A	0032007	biological_process	negative regulation of TOR signaling
A	0033596	cellular_component	TSC1-TSC2 complex
A	0042803	molecular_function	protein homodimerization activity
A	0043276	biological_process	anoikis
A	0043547	biological_process	positive regulation of GTPase activity
A	0045202	cellular_component	synapse
A	0046626	biological_process	regulation of insulin receptor signaling pathway
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050918	biological_process	positive chemotaxis
A	0051056	biological_process	regulation of small GTPase mediated signal transduction
A	0051726	biological_process	regulation of cell cycle
A	0051879	molecular_function	Hsp90 protein binding
A	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	1901525	biological_process	negative regulation of mitophagy
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0001843	biological_process	neural tube closure
B	0005096	molecular_function	GTPase activator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0006606	biological_process	protein import into nucleus
B	0006897	biological_process	endocytosis
B	0007507	biological_process	heart development
B	0008104	biological_process	intracellular protein localization
B	0008285	biological_process	negative regulation of cell population proliferation
B	0009267	biological_process	cellular response to starvation
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
B	0016239	biological_process	positive regulation of macroautophagy
B	0016241	biological_process	regulation of macroautophagy
B	0019902	molecular_function	phosphatase binding
B	0030100	biological_process	regulation of endocytosis
B	0030178	biological_process	negative regulation of Wnt signaling pathway
B	0031267	molecular_function	small GTPase binding
B	0032007	biological_process	negative regulation of TOR signaling
B	0033596	cellular_component	TSC1-TSC2 complex
B	0042803	molecular_function	protein homodimerization activity
B	0043276	biological_process	anoikis
B	0043547	biological_process	positive regulation of GTPase activity
B	0045202	cellular_component	synapse
B	0046626	biological_process	regulation of insulin receptor signaling pathway
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050918	biological_process	positive chemotaxis
B	0051056	biological_process	regulation of small GTPase mediated signal transduction
B	0051726	biological_process	regulation of cell cycle
B	0051879	molecular_function	Hsp90 protein binding
B	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	1901525	biological_process	negative regulation of mitophagy
B	1904262	biological_process	negative regulation of TORC1 signaling
C	0001822	biological_process	kidney development
C	0001843	biological_process	neural tube closure
C	0001952	biological_process	regulation of cell-matrix adhesion
C	0002250	biological_process	adaptive immune response
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005765	cellular_component	lysosomal membrane
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0005884	cellular_component	actin filament
C	0005886	cellular_component	plasma membrane
C	0005938	cellular_component	cell cortex
C	0006457	biological_process	protein folding
C	0006813	biological_process	potassium ion transport
C	0007160	biological_process	cell-matrix adhesion
C	0007399	biological_process	nervous system development
C	0008283	biological_process	cell population proliferation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008306	biological_process	associative learning
C	0008344	biological_process	adult locomotory behavior
C	0009267	biological_process	cellular response to starvation
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0016242	biological_process	negative regulation of macroautophagy
C	0021766	biological_process	hippocampus development
C	0021987	biological_process	cerebral cortex development
C	0030027	cellular_component	lamellipodium
C	0030030	biological_process	cell projection organization
C	0030544	molecular_function	Hsp70 protein binding
C	0032007	biological_process	negative regulation of TOR signaling
C	0032780	biological_process	negative regulation of ATP-dependent activity
C	0032868	biological_process	response to insulin
C	0032991	cellular_component	protein-containing complex
C	0033596	cellular_component	TSC1-TSC2 complex
C	0035869	cellular_component	ciliary transition zone
C	0036064	cellular_component	ciliary basal body
C	0036294	biological_process	cellular response to decreased oxygen levels
C	0042030	molecular_function	ATPase inhibitor activity
C	0042552	biological_process	myelination
C	0043379	biological_process	memory T cell differentiation
C	0044183	molecular_function	protein folding chaperone
C	0045792	biological_process	negative regulation of cell size
C	0046323	biological_process	D-glucose import
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050808	biological_process	synapse organization
C	0050821	biological_process	protein stabilization
C	0051087	molecular_function	protein-folding chaperone binding
C	0051492	biological_process	regulation of stress fiber assembly
C	0051726	biological_process	regulation of cell cycle
C	0051879	molecular_function	Hsp90 protein binding
C	0051894	biological_process	positive regulation of focal adhesion assembly
C	0055007	biological_process	cardiac muscle cell differentiation
C	0090630	biological_process	activation of GTPase activity
C	0101031	cellular_component	protein folding chaperone complex
C	1904262	biological_process	negative regulation of TORC1 signaling
D	0001822	biological_process	kidney development
D	0001843	biological_process	neural tube closure
D	0001952	biological_process	regulation of cell-matrix adhesion
D	0002250	biological_process	adaptive immune response
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005765	cellular_component	lysosomal membrane
D	0005811	cellular_component	lipid droplet
D	0005829	cellular_component	cytosol
D	0005884	cellular_component	actin filament
D	0005886	cellular_component	plasma membrane
D	0005938	cellular_component	cell cortex
D	0006457	biological_process	protein folding
D	0006813	biological_process	potassium ion transport
D	0007160	biological_process	cell-matrix adhesion
D	0007399	biological_process	nervous system development
D	0008283	biological_process	cell population proliferation
D	0008285	biological_process	negative regulation of cell population proliferation
D	0008306	biological_process	associative learning
D	0008344	biological_process	adult locomotory behavior
D	0009267	biological_process	cellular response to starvation
D	0014069	cellular_component	postsynaptic density
D	0016020	cellular_component	membrane
D	0016242	biological_process	negative regulation of macroautophagy
D	0021766	biological_process	hippocampus development
D	0021987	biological_process	cerebral cortex development
D	0030027	cellular_component	lamellipodium
D	0030030	biological_process	cell projection organization
D	0030544	molecular_function	Hsp70 protein binding
D	0032007	biological_process	negative regulation of TOR signaling
D	0032780	biological_process	negative regulation of ATP-dependent activity
D	0032868	biological_process	response to insulin
D	0032991	cellular_component	protein-containing complex
D	0033596	cellular_component	TSC1-TSC2 complex
D	0035869	cellular_component	ciliary transition zone
D	0036064	cellular_component	ciliary basal body
D	0036294	biological_process	cellular response to decreased oxygen levels
D	0042030	molecular_function	ATPase inhibitor activity
D	0042552	biological_process	myelination
D	0043379	biological_process	memory T cell differentiation
D	0044183	molecular_function	protein folding chaperone
D	0045792	biological_process	negative regulation of cell size
D	0046323	biological_process	D-glucose import
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050808	biological_process	synapse organization
D	0050821	biological_process	protein stabilization
D	0051087	molecular_function	protein-folding chaperone binding
D	0051492	biological_process	regulation of stress fiber assembly
D	0051726	biological_process	regulation of cell cycle
D	0051879	molecular_function	Hsp90 protein binding
D	0051894	biological_process	positive regulation of focal adhesion assembly
D	0055007	biological_process	cardiac muscle cell differentiation
D	0090630	biological_process	activation of GTPase activity
D	0101031	cellular_component	protein folding chaperone complex
D	1904262	biological_process	negative regulation of TORC1 signaling
E	0005096	molecular_function	GTPase activator activity
E	0005515	molecular_function	protein binding
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0009267	biological_process	cellular response to starvation
E	0031267	molecular_function	small GTPase binding
E	0031398	biological_process	positive regulation of protein ubiquitination
E	0031410	cellular_component	cytoplasmic vesicle
E	0032007	biological_process	negative regulation of TOR signaling
E	0033596	cellular_component	TSC1-TSC2 complex
E	0036064	cellular_component	ciliary basal body
E	0043547	biological_process	positive regulation of GTPase activity
E	0062078	molecular_function	TSC1-TSC2 complex binding
E	0070848	biological_process	response to growth factor
E	0090630	biological_process	activation of GTPase activity
E	1902018	biological_process	negative regulation of cilium assembly
E	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18308511","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	181
Details	Domain: {"description":"Rab-GAP TBC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00163","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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